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- 저자 : Doaa Domyati (검색결과 1 건)
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Thermal stability and antibacterial activity of Er2O3, and Co3O4 scattered in polycaprolactone
Doaa Domyati 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
The development of a biocompatible wound dressing with good antibacterial and fasting for healing skinwounds is still a challenge. Through the film casting, a polycaprolactone (PCL) scaffold is manufacturedwith different ratios of metal oxides such as Erbium oxide (Er2O3) and Cobalt oxide (Co3O4). The fabricatedfilms were examined using XRD, SEM, FTIR, and XPS. The study of surface morphology exhibitsdiameters of pores in the range of 1–7 lm. The contact angle tested with a drop of water and showedthat it is in decreased from 55.67for pure PCL then lowered to 47.85for Er2O3@PCL and slightly decreasedto 41.195for Co3O4@PCL and a significant decrease occurred to 34.435for Er2O3/Co3O4@PCL and then itslightly increased to 38.02for Er2O3/Co3O4/GO@PCL. In addition, the TGA started from room temperatureup to 200 C by a weight loss of around 3 %. The cell viability is examined for Er2O3/Co3O4/GO@PCL and itshowed that the IC50 at 4000 lg/ml and with lowering the concentration, the viable cells tend to increase. On the other hand, an antibacterial test against E. coli and S. aureus showed high antibacterial activity inEr2O3/Co3O4/GO@PCL. The wound bandages were developed using loaded materials which representgood biocompatibility, biodegradability, and high antibacterial behavior that inhibit bacterial growthon the surface of the wound which might accelerate the wound healing period. Moreover, it has beenapproved that, the surface porosity might enhance the mutual transfer of gases between the woundand the outer environment.
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