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김범규,황도현,윤홍주,서원찬,Kim, Bum-Kyu,Hwang, Do-Hyun,Yoon, Hong-Joo,Seo, Won-Chan 한국전자통신학회 2015 한국전자통신학회 논문지 Vol.10 No.5
This study carried out in order to investigate the most basic elements of suitability selection methods for composition of artificial reef. Acquired data by in-situ measurements and satellite remote sensing analysed in applying GIS. To identify the characteristic of marine environment around the West Sea, the South Sea and the East Sea of Korea, physical conditions-seabed sediment and depth, biological conditions-chlorophyll-${\alpha}$, chemical conditions-Sea Surface Temperature(SST) and DO were used. Suitable sites for artificial reef are selected Taean Peninsula, Geoje, Wando, Pohang, Seocheon, etc. From now on, it will be helpful to effectively utilize artificial reef as well as construct synthetic database. It is also expected to use basic data for artificial reef facilities management. 본 논문는 인공어초 조성의 가장 기본적인 요소인 적지선정을 위한 방법에 대해 고찰하였다. 현장관측과 위성 원격탐사(Remote Sensing, RS)로 획득한 자료를 지리정보시스템(Geographic Information System, GIS)을 활용하여 분석하였다. 한반도 주변해역의 해양환경 특성을 파악하기 위해 물리적 조건-해저저질, 수심, 생물적 조건-클로로필-${\alpha}$, 화학적 조건-해수온, DO를 활용하였다. 인공어초 적지로는 태안반도, 거제, 완도, 포항, 서천 등이 나타났다. 향후 본 연구는 인공어초 설치의 효율적인 활용뿐만 아니라 종합적인 데이터베이스의 구축에 도움을 줄 수 있을 것이다. 또한 인공어초 시설관리의 기초자료로 활용할 수 있을 것으로 기대된다.
( Do Young Kim ),( Won Young Tak ),( Stefan Zeuzem ),( Lawrence Serfaty ),( John M. Vierling ),( Wendy Cheng ),( Jacob George ),( Jan Sperl ),( Simone I. Strasser ),( Hiromitsu Kumada ),( Peggy Hwang 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: GT1b is the most common HCV genotype globally, accounting for the largest proportion of infections in Europe, Latin America, Russia, Turkey, and East Asia. We report the efficacy of 12 weeks of once-daily elbasvir/grazoprevir (50 mg/100 mg) (NS5A inhibitor/ NS3/4 protease inhibitor) in HCV GT1b-infected patients enrolled in the clinical development program. Methods: This analysis of treatment-naïve and treatment-experienced GT1b-infected patients used data pooled from 11 trials involving 30 countries and included 1070 patients with/without cirrhosis, chronic kidney disease (CKD), and HIV co-infection. Cirrhosis (F4, compensated) was confirmed by either liver biopsy or noninvasive tests. Patients with Stage 4 or Stage 5 CKD on hemodialysis were included. HIV/HCV co-infected patients were required to be on a stable antiretroviral regimen (ARV) (tenofovir or abacavir, emtricitabine or lamivudine, and either raltegrevir, dolutegravir, or rilpivirine) with CD4 >200/μL and HIV viral load undetectable, or if not on ARVs, have CD4 >500/μL and viral load < 50,000 IU/mL. The primary endpoint was the proportion of patients with HCV RNA below the lower limit of quantitation 12 weeks after treatment (SVR12). Efficacy data are presented for the full analysis set (FAS), which includes all patients who received at least one dose of study medication, and for the per-protocol (PP) population, which excludes nonvirologic failures. Results: A total of 1,070 patients were included in the analysis. Mean patient age was 53.7 years (range, 19-80); 50% were male; 47% were white, 43% were Asian, and 9% were black or African American; 20% were treatment-experienced; 39% had a baseline viral load >2,000,000 IU/mL; and 18% had evidence of cirrhosis. SVR12 was 97% (1040/1070) in the FAS; 15 patients (1.4%) were categorized as virologic failures and 15 (1.4%) were categorized as nonvirologic failures (lost-to-follow-up or withdrawal). Excluding the nonvirologic failures, SVR12 was 99% (1040/1055) in the PP analysis. There were no notable differences in subgroup analyses: SVR12 was 97% in both treatment-naïve and treatment-experienced patients; 99% in cirrhotics and 97% in noncirrhotics; 98% in patients with a baseline viral load < 2,000,000 IU/mL and 97% in patients with a baseline viral >2,000,000 IU/mL; 94% in HIV/HCV co-infected patients; and 100% and 95% in patients with Stage 4 or 5 CKD, respectively. Conclusions: High efficacy was achieved in the GT1b-infected population treated with elbasvir/grazoprevir for 12 weeks, with comparable efficacy across subgroups, including those with cirrhosis, high baseline viral load, and prior treatment failures.
Improved FOC of IPMSM using Finite-state Model Predictive Current Control for EV
Won, Il-Kuen,Hwang, Jun-Ha,Kim, Do-Yun,Choo, Kyoung-Min,Lee, Soon-Ryung,Won, Chung-Yuen The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.5
Interior permanent magnet synchronous motor (IPMSM) is most commonly used in the automotive industry as a traction motor for electric vehicle (EV). In electric vehicle, the torque output rapidly changes according to the operation of the accelerator and the braking of the driver. The transient torques are thus generated very frequently in accordance with the variable speed control of the driver. Therefore, in this paper, a method for improving the torque response in the transient states of IPMSM is proposed. In order to complement the disadvantages of the conventional PI current controller in the field oriented control (FOC), the finite-state model predictive current control and 2D-LUT is applied to improve the torque response at the torque transient period. Simulation and experiment results are given to verify the reliability of the proposed method.
Do Hyun Kim,Mi Hyun Lim,전정호,박선화,WeonSun Lee,Sang Hi Park,Mi Yeon Kwon,Se-Hwan Hwang,Sung Won Kim 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.6
BACKGROUND: In this study, we manufactured a complex of human nasal septal cartilage (hNC) with polycaprolactone (PCL) for transplantation into cartilaginous skeletal defects and evaluated their characteristics. METHODS: Nasal septum tissue was obtained from five patients aged C 20 years who were undergoing septoplasty. hNCs were isolated and subcultured for three passages in vitro. To formulate the cell–PCL complex, we used type I collagen as an adhesive between chondrocyte and PCL. Immunofluorescence staining, cell viability and growth in the hNC–PCL complex, and mycoplasma contamination were assessed. RESULTS: hNCs in PCL showed viability C 70% and remained at these levels for 9 h of incubation at 4 C. Immunostaining of the hNC–PCL complex also showed high expression levels of chondrocyte-specific protein, COL2A1, SOX9, and aggrecan during 24 h of clinically applicable conditions. CONCLUSION: The hNC–PCL complex may be a valuable therapeutic agent for implantation into injured cartilage tissue, and can be used clinically to repair cartilaginous skeletal defects. From a clinical perspective, it is important to set the short duration of the implantation process to achieve effective functional implantation.
Systematic Reliability Study of Top-Gate p- and n-Channel Organic Field-Effect Transistors
Hwang, Do Kyung,Fuentes-Hernandez, Canek,Fenoll, Mathieu,Yun, Minseong,Park, Jihoon,Shim, Jae Won,Knauer, Keith A.,Dindar, Amir,Kim, Hyungchul,Kim, Yongjin,Kim, Jungbae,Cheun, Hyeunseok,Payne, Marcia American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.5
<P>We report on a systematic investigation on the performance and stability of p-channel and n-channel top-gate OFETs, with a CYTOP/Al<SUB>2</SUB>O<SUB>3</SUB> bilayer gate dielectric, exposed to controlled dry oxygen and humid atmospheres. Despite the severe conditions of environmental exposure, p-channel and n-channel top-gate OFETs show only minor changes of their performance parameters without undergoing irreversible damage. When correlated with the conditions of environmental exposure, these changes provide new insight into the possible physical mechanisms in the presence of oxygen and water. Photoexcited charge collection spectroscopy experiments provided further evidence of oxygen and water effects on OFETs. Top-gate OFETs also display outstanding durability, even when exposed to oxygen plasma and subsequent immersion in water or operated under aqueous media. These remarkable properties arise as a consequence of the use of relatively air stable organic semiconductors and proper engineering of the OFET structure.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-5/am405424k/production/images/medium/am-2013-05424k_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am405424k'>ACS Electronic Supporting Info</A></P>
Development of Prediction Equation of Diffusing Capacity of Lung for Koreans
Hwang, Yong Il,Park, Yong Bum,Yoon, Hyoung Kyu,Lim, Seong Yong,Kim, Tae-Hyung,Park, Joo Hun,Lee, Won-Yeon,Park, Seong Ju,Lee, Sei Won,Kim, Woo Jin,Kim, Ki Uk,Shin, Kyeong Cheol,Kim, Do Jin,Kim, Hui Ju The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.1
Background: The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. Methods: Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study. Results: Using linear regression analysis, a new predicting equation for diffusing capacity was developed. For men, the following new equations were developed: carbon monoxide diffusing capacity (DLco)=-10.4433-0.1434${\times}$age (year)+0.2482${\times}$heights (cm); DLco/alveolar volume (VA)=6.01507-0.02374${\times}$age (year)-0.00233${\times}$heights (cm). For women the prediction equations were described as followed: DLco=-12.8895-0.0532${\times}$age (year)+0.2145${\times}$heights (cm) and DLco/VA=7.69516-0.02219${\times}$age (year)-0.01377${\times}$heights (cm). All equations were internally validated by k-fold cross validation method. Conclusion: In this study, we developed new prediction equations for the diffusing capacity of the lungs of Koreans. A further study is needed to validate the new predicting equation for diffusing capacity.
Hwang, Jong-ho,Choi, Cheol Woong,Kim, Hyung-Wook,Kim, Do Hyung,Kwak, Tae Won,Lee, Hye Myeong,Kim, Cy hyun,Chung, Chung Wook,Jeong, Young-II,Kang, Dae Hwan Dove Medical Press 2013 International journal of nanomedicine Vol.8 No.-
<P><B>Purpose</B></P><P>Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using pH-sensitive polymers has attracted attention because solid tumors have an acidic environment. A dextran-<I>b</I>-poly(<I>L</I>-histidine) (DexPHS) copolymer was synthesized and pH-responsive nanoparticles were fabricated for drug targeting.</P><P><B>Methods and results</B></P><P>A DexPHS block copolymer was synthesized by attaching the reductive end of dextran to the amine groups of poly(L-histidine). pH-responsive nanoparticles incorporating doxorubicin were fabricated and studied in HuCC-T1 cholangiocarcinoma cells. Synthesis of DexPHS was confirmed by 1H nuclear magnetic resonance spectroscopy, with specific peaks of dextran and PHS observed at 2–5 ppm and 7.4–9.0 ppm, respectively. DexPHS nanoparticles showed changes in particle size with pH sensitivity, ie, the size of the nanoparticles increased at an acidic pH and decreased at a basic pH. DexPHS block copolymer nanoparticles incorporating doxorubicin were prepared using the nanoprecipitation dialysis method. The doxorubicin release rate was increased at acidic pH compared with basic pH, indicating that DexPHS nanoparticles have pH-sensitive properties and that drug release can be controlled by variations in pH. The antitumor activity of DexPHS nanoparticles incorporating doxorubicin were studied using HuCC-T1 cholangiocarcinoma cells. Viability was decreased in cells treated with nanoparticles at acidic pH, whereas cell viability in response to treatment with doxorubicin did not vary according to changes of pH.</P><P><B>Conclusion</B></P><P>Our results indicated that DexPHS polymeric micelles are promising candidates for antitumor drug targeting.</P>