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- 저자 : Dinh Vinh Do (검색결과 4 건)
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Dinh Vinh Do,박소영,Giang Thi Nguyen,최대희,조은희 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.4
Background: Hepatic stellate cells (HSCs) are the central players interacting with multiple cell types in liver fibrosis. The crosstalkbetween HSCs and macrophages has recently become clearer. Irisin, an exercise-responsive myokine, was known to have a potentially protective role in liver and renal fibrosis, especially in connection with stellate cells. This study investigated the effects of irisinon the interaction between HSCs and macrophages. Methods: Tamm-Horsfall protein-1 (THP-1) human monocytes were differentiated into macrophages, polarized into the inflammatory M1 phenotype with lipopolysaccharide. Lieming Xu-2 (LX-2) cells, human HSCs, were treated with conditioned media (CM)from M1 macrophages, with or without recombinant irisin. HSCs responses to CM from M1 macrophages were evaluated regardingactivation, proliferation, wound healing, trans-well migration, contractility, and related signaling pathway. Results: CM from M1 macrophages significantly promoted HSC proliferation, wound healing, transwell migration, and contractility, but not activation of HSCs. Irisin co-treatment attenuated these responses of HSCs to CM. However, CM and irisin treatment didnot induce any changes in HSC activation. Further, irisin co-treatment alleviated CM-induced increase of phopho-protein kinase B(pAKT), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinases-1 (TIMP-1). Conclusion: These findings suggested that irisin may play a protective role in the pathogenesis of liver fibrosis, especially whenworking in the crosstalk between HSCs and macrophages.
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Vinh-Thanh Tran,Duc-Tri Do,Minh-Khai Nguyen,Dinh-Tuyen Nguyen 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
In this paper, a space vector pulse-width modulation (SVPWM) control scheme for the three-level quasi-switched boost T-type inverter (TL-qSBT2I) to reduce common mode is presented. The magnitude and slew rate of common-mode voltage (CMV) are reduced by using the proposed method. By properly selecting the shoot-through (ST) phase, the ST states are inserted within a small vector so that the active states and output voltage are unchanged. In this method, the ST duty cycle is kept constant to obtain the modulation index as high as possible while the duty cycles of the two additional switches are the control variables. The proposed method can mitigate the peak value of CMV up to 50% and the RMS value up to 35.3% as compared to the conventional SVPWM control method. To verify the operating principle of the TL-qSBT<SUP>2</SUP>I, the simulation and experimental results are shown.
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Giang Nguyen,So Young Park,Dinh Vinh Do,Dae-Hee Choi,조은희 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.6
Background: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) are used clinically as oral antidiabetic agents. Although DPP-4Is are known to ameliorate liver fibrosis, the protective mechanism of DPP-4Is in liver fibrosis remains obscure. In this study, gemigliptin was used to investigate the potential of DPP-4Is to alleviate the progression of liver fibrosis. Methods: To clarify the effects and mechanisms of gemigliptin, we conducted various experiments in LX-2 cells (immortalized human hepatic stellate cells [HSCs], the principal effectors of hepatic fibrogenesis), which were activated by succinate and exhibited elevated expression of α-smooth muscle actin, collagen type 1, and pro-inflammatory cytokines and increased cell proliferation. Invivo, we examined the effects and mechanisms of gemigliptin on a high-fat, high-cholesterol–induced mouse model of nonalcoholic steatohepatitis (NASH). Results: Gemigliptin decreased the expression of fibrogenesis markers and reduced the abnormal proliferation of HSCs. In addition, gemigliptin reduced the succinate-induced production of mitochondrial reactive oxygen species (ROS), intracellular ROS, and mitochondrial fission in HSCs. Furthermore, in the mouse model of NASH-induced liver fibrosis, gemigliptin alleviated both liver fibrosis and mitochondrial dysfunction. Conclusion: Gemigliptin protected against HSC activation and liver fibrosis by alleviating mitochondrial dysfunction and ROS production, indicating its potential as a strategy for preventing the development of liver disease.
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Kim, Dae Won,Huh, Eun Soo,Park, Sang Do,Nguyen, Ly Vinh,Nguyen, Mai Dao,Kim, Hoon Sik,Cheong, Minserk,Nguyen, Dinh Quan WILEY-VCH Verlag 2010 Advanced Synthesis & Catalysis Vol. No.
<P>The methoxycarbonylation reactions of aliphatic diamines with dimethyl carbonate are accelerated greatly in the presence of water. Theoretical investigations on the mechanistic aspects of the methoxycarbonylation of 1,6-hexanediamine strongly suggest that the hydroxide ion, generated in situ from the interaction of 1,6-hexanediamine with water, is an active catalytic species and plays a pivotal role in the rate-determining hydrogen abstraction step from the amino group.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/16154150-2010-352-2-3-ADSC200900699-content.gif' alt='wiley_img/16154150-2010-352-2-3-ADSC200900699-content'> </P>
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