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Mustafa Aslan,Didem Deliorman Orhan,Nil?fer Orhan,Ekrem Sezik,Erdem Yesilada 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Helichrysum graveolens(Bieb.) Sweet (Asteraceae) grows widely in Turkey. Capitulums of H. graveolensareused in the treatment of many diseases such as jaundice and wound healing and as a diuretic in the rural areas of Anatolia.The decoction from the capitulums of the plant is consumed for the symptoms of diabetes mellitus in folk medicine. In thepresent study, the hypoglycemic, antihyperglycemic, and antioxidant potentials of water and ethanol extracts of H. graveolenswere evaluated by using in vivomethods in normal and streptozotocin-induced diabetic rats. Blood glucose levels of animalswere measured by the glucose oxidase method. The antioxidant activity of these extracts was also studied in liver, kidney,and heart tissues. In order to determine antioxidant activity, tissue malondialdehyde and reduced glutathione levels were mea-sured by using spectrophotometric methods. The experimental data obtained from water and ethanol extracts of capitulumsconfirmed the folkloric utilization. In order to discuss the role of polyphenolic components in the relevant activity, total phe-nol and flavonoid contents of each extract were also determined using the Folin-Ciocalteu reagent, and a positive correlationwas observed.