http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Dhonde, Satish G. (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Anticancer Properties of Total Alkaloid fraction of Solanum pseudocapsicum unripe fruits
Badami, Shrishailappa,Dhonde, Satish G.,Reddy SA, Manohar,P., Vijayan,B, Suresh Kyung Hee Oriental Medicine Research Center 2004 Oriental pharmacy and experimental medicine Vol.4 No.1
The total alkaloid fraction of the methanolic extract of Solanum pseudocapsicum unripe fruits was tested for its in-vivo anticancer activity against Dalton's Lymphoma Ascites model in mice. The total alkaloid fraction at 5.0 and 10.0 mg/kg body weight showed significant increase in the mean survival time and the percentage increase in the life span of tumor bearing mice. The increase in the body weight was found to be less than that of the control. However, the treatment at 20 mg/ kg body weight was found to be toxic and showed a decrease in the mean survival time, and body weight when compared to control mice. The antitumor activity observed may be due to the cytotoxic activity of the total alkaloid fraction.
-
Shear Strength of Prestressed Steel Fiber Concrete I-Beams
Padmanabha Rao Tadepalli,Hemant B. Dhonde,Y. L. Mo,Thomas T. C. Hsu 한국콘크리트학회 2015 International Journal of Concrete Structures and M Vol.9 No.3
Six full scale prestressed concrete (PC) I beams with steel fibers were tested to failure in this work. Beams were cast without any traditional transverse steel reinforcement. The main objective of the study was to determine the effects of two variables the shear span to depth ratio and steel fiber dosage, on the web shear and flexural shear modes of beam failure. The beams were subjected to concentrated vertical loads up to their maximum shear or moment capacity using four hydraulic actuators in load and displacement control mode. During the load tests, vertical deflections and displacements at several critical points on the web in the end zone of the beams were measured. From the load tests, it was observed that the shear capacities of the beams increased significantly due to the addition of steel fibers in concrete. Complete replacement of traditional shear reinforcement with steel fibers also increased the ductility and energy dissipation capacity of the PC I beams.
-
Brain encoding of acupuncture sensation - Coupling on-line rating with fMRI
Napadow, V.,Dhond, R.P.,Kim, J.,LaCount, L.,Vangel, M.,Harris, R.E.,Kettner, N.,Park, K. Academic Press 2009 NeuroImage Vol.47 No.3
Acupuncture-induced sensations have historically been associated with clinical efficacy. These sensations are atypical, arising from sub-dermal receptors, and their neural encoding is not well known. In this fMRI study, subjects were stimulated at acupoint PC-6, while rating sensation with a custom-built, MR-compatible potentiometer. Separate runs included real (ACUP) and sham (SHAM) acupuncture, the latter characterized by non-insertive, cutaneous stimulation. FMRI data analysis was guided by the on-line rating timeseries, thereby localizing brain correlates of acupuncture sensation. Sensation ratings correlated with stimulation more (p<0.001) for SHAM (r=0.63) than for ACUP (r=0.32). ACUP induced stronger and more varied sensations with significant persistence into no-stimulation blocks, leading to more run-time spent rating low and moderate sensations compared to SHAM. ACUP sensation correlated with activation in regions associated with sensorimotor (SII, insula) and cognitive (dorsomedial prefrontal cortex (dmPFC)) processing, and deactivation in default-mode network (DMN) regions (posterior cingulate, precuneus). Compared to SHAM, ACUP yielded greater activity in both anterior and posterior dmPFC and dlPFC. In contrast, SHAM produced greater activation in sensorimotor (SI, SII, insula) and greater deactivation in DMN regions. Thus, brain encoding of ACUP sensation (more persistent and varied, leading to increased cognitive load) demonstrated greater activity in both cognitive/evaluative (posterior dmPFC) and emotional/interoceptive (anterior dmPFC) cortical regions. Increased cognitive load and dmPFC activity may be a salient component of acupuncture analgesia - sensations focus attention and accentuate bodily awareness, contributing to enhanced top-down modulation of any nociceptive afference and central pain networks. Hence, acupuncture may function as a somatosensory-guided mind-body therapy.
-
Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture
Napadow, V.,Dhond, R.,Park, K.,Kim, J.,Makris, N.,Kwong, K.K.,Harris, R.E.,Purdon, P.L.,Kettner, N.,Hui, K.K.S. Academic Press 2009 NeuroImage Vol.47 No.1
Acupuncture modulation of activity in the human brainstem is not well known. This structure is plagued by physiological artifact in neuroimaging experiments. In addition, most studies have used short (<15 min) block designs, which miss delayed responses following longer duration stimulation. We used brainstem-focused cardiac-gated fMRI and evaluated time-variant brain response to longer duration (>30 min) stimulation with verum (VA, electro-stimulation at acupoint ST-36) or sham point (SPA, non-acupoint electro-stimulation) acupuncture. Our results provide evidence that acupuncture modulates brainstem nuclei important to endogenous monoaminergic and opioidergic systems. Specifically, VA modulated activity in the substantia nigra (SN), nucleus raphe magnus, locus ceruleus, nucleus cuneiformis, and periaqueductal gray (PAG). Activation in the ventrolateral PAG was greater for VA compared to SPA. Linearly decreasing time-variant activation, suggesting classical habituation, was found in response to both VA and SPA in sensorimotor (SII, posterior insula, premotor cortex) brain regions. However, VA also produced linearly time-variant activity in limbic regions (amygdala, hippocampus, and SN), which was bimodal and not likely habituation - consisting of activation in early blocks, and deactivation by the end of the run. Thus, acupuncture induces different brain response early, compared to 20-30 min after stimulation. We attribute the fMRI differences between VA and SPA to more varied and stronger psychophysical response induced by VA. Our study demonstrates that acupuncture modulation of brainstem structures can be studied non-invasively in humans, allowing for comparison to animal studies. Our protocol also demonstrates a fMRI approach to study habituation and other time-variant phenomena over longer time durations.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
