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        Gas phase dehydrogenation of ethanol using maleic anhydride as hydrogen acceptor over Cu/hydroxylapatite, Cu/SBA-15, and Cu/MCM-41 catalysts

        Dezhi Gao,Hengbo Yin,Aili Wang,Lingqin Shen,Shuxin Liu 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.26 No.-

        Hydroxylapatite (HAP), SBA-15, and MCM-41 supported copper catalysts were used for the coupling reaction between ethanol dehydrogenation and maleic anhydride hydrogenation. CuO species were completely reduced to metallic copper (Cu0), which was the active site for the coupling reaction. Cu/SBA- 15 and Cu/MCM-41 catalysts favored the formation of acetaldehyde and diethyl succinate. Cu/HAP catalysts with high basicity and small crystallite-sized Cu0 nanoparticles favored the dehydrogenation of ethanol to ethyl acetate with the maximum selectivity of 69.5% and the hydrogenation of maleic anhydride to g-butyrolactone with the maximum selectivity of 89.6%. The coupling reaction had good compensation for reaction heat and hydrogen.

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        Effects of Diosgenin on Cell Proliferation Induced by IGF-1 in Primary Human Thyrocytes

        Dezhi Bian,Zhiwei Li,Hongyan Ma,Sumin Mu,Chunyan Ma,Bin Cui,Ling Gao,Jiajun Zhao 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.6

        Others and our previous studies showed that the increase of IGF-1 was involved in the formation of goiter. Our aim here was to evaluate the possible effects of diosgenin on cell proliferation induced by IGF-1 in primary human thyroid cells. The cells were treated with or without different concentrations of diosgenin in the present or absent of IGF-1 for 24, 48 and 72 h, respectively. Cell viability was determined by MTT, and cell proliferation was tested by EdU assay, and cell cycle analysis was performed by FACS. In addition, Cyclin D1 and B1 protein expression was tested by Western Blotting, respectively. We found that IGF-1 promoted cell cycle progression to S phase and increased the primary human thyroid cells proliferation. Diosgenin decreased the protein expression of cyclin D1 and resulted in cell G_0 /G_1 arrest. Importantly, when the human thyrocytes were exposed to diosgenin in the present of IGF-1,the IGF-1 inducing proliferation was significantly decreased and the proportion of the cells in G_0 /G_1 phase was increased, while that of S phase was decreased. This study shows that diosgenin inhibited cell proliferation, caused G_0 /G_1 arrest, and could inhibit cell proliferation induced by IGF-1 in primary human thyroid cells.

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        Data Augmentation Method Based on Improved Generative Adversarial Network for the Sucker Rod Pump System

        Dezhi Hao,Xianwen Gao,Wenhai Qi 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.11

        In this paper, a novel data augmentation method is proposed for imbalanced fault diagnosis in the sucker rod pumping system (SRPS) based on the improved generative adversarial network (GAN). The dynamometer cards (DCs) of minority fault classes are expanded steadily through learning the data distribution of the original imbalanced training data. The generalization ability and accuracy of the different fault diagnosis models are improved with the expanded DCs. Firstly, benefit from introducing the auxiliary conditional information to the Wasserstein GAN with gradient penalty (WGAN-GP), a stable and practical framework is constructed to generate specific categories of DCs. Secondly, the traditional random noise is replaced by the Gaussian mixture noise to guarantee the diversity of the generated DCs with few training samples. Moreover, problematic training, such as unstable training and mode collapse, is effectively avoided with the presented optimization strategy, training structure and data processing method. Eventually, generated data evaluation and comparative experiments are conducted using practical DCs collected from several oil wells with similar working conditions in the northeastern of China. The results verify the validity of the proposed data augmentation method.

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        Methanol dehydrogenation to methyl formate catalyzed by SiO2-, hydroxyapatite-, and MgO-supported copper catalysts and reaction kinetics

        Zhipeng Lu,Hengbo Yin,Dezhi Gao,Aili Wang,Shuxin Liu 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.31 No.-

        Catalytic dehydrogenation of methanol to methyl formate over SiO2-, hydroxyapatite (HAP)-, and MgOsupportedcopper catalysts was investigated. Metallic copper (Cu0) was the active site for the methanoldehydrogenation to methyl formate. Cu/SiO2 catalyst with low basicity and weak-strength basic siteeffectively catalyzed the methanol dehydrogenation to methyl formate. Cu/HAP and Cu/MgO catalystswith high basicities and strong-strength basic sites caused the degradation of the resultant methylformate to CO and H2. Over Cu(5)/SiO2 catalyst, the reaction activation energies for methanoldehydrogenation to methyl formate and methyl formate degradation to CO and H2 were 58.3 and91.1 kJ mol 1, respectively.

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