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Seo, Seong Deok,Paik, Hyun-jong,Lim, Dong-ha,Lee, Ju Dong American Chemical Society 2017 ENERGY AND FUELS Vol.31 No.6
<P>Poly(N-vinylcaprolactarn) (PVCap) has previously been shown to be an outstanding low-dosage hydrate inhibitor (LDHI). The inhibition performance of LDHI is known to be influenced by molecular weight (M-w) and molecular weight distribution. In this study, PVCaps were synthesized by two different methods. The first method; reversible addition fragmentation chain transfer (RAFT) polymerization, was used to prepare PVCap with a narrow molecular weight distribution (about M-w/M-n < 1.5), which is close to theoretical values. The second method) free radical polymerization (FRP), was used to obtain a broad molecular weight distribution (about M-w/M-n > 1.5). In a semi-batch stirrer reactor, hydrate inhibition performance of PVCap was evaluated. It was found that the inhibition performance was increased when the PVCap molecular weight decreased. PVCap with the narrower molecular weight distribution also showed the better inhibition performance.</P>
Expression of Neutrophil Gelatinase-Associated Lipocalin in Skin Epidermis
Seo, Seong Jun,Ahn, Ji-Young,Hong, Chang-Kwun,Seo, Eun-Young,Kye, Kyung-Chae,Lee, Woong-Hee,Lee, Sang-Keun,Lim, Jong-Soon,Hahn, Myong-Joon,Kjeldsen, Lars,Borregaard, Niels,Kim, Chang Deok,Park, Jang-K Elsevier 2006 The Journal of investigative dermatology Vol.126 No.2
Thermodynamic and kinetic analysis of gas hydrates for desalination of saturated salinity water
Seo, Seong Deok,Hong, Sang Yeon,Sum, Amadeu K.,Lee, Kun-Hong,Lee, Ju Dong,Lee, Bo Ram Elsevier 2019 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.370 No.-
<P><B>Abstract</B></P> <P>The shortage of fresh water is among the most serious issues in the world. A representative technology to overcome the problem is desalination, but most conventional methods (RO membrane or thermal distillation) have been focused on the treatment of relatively low salinity water, such as seawater or brackish water. To strengthen water security, in this study, we introduce a possibly economic technology for desalination of high salinity water (over-saturated concentration, in this study, a 30 wt% NaCl system) via gas hydrate formation by coupling LNG waste cold energy. First, the thermodynamic effects of NaCl on CH<SUB>4</SUB> (methane), SF<SUB>6</SUB> (sulfur hexafluoride), and HFC-134a hydrates were investigated. Based on the phase equilibrium of each hydrate, experimental pressures for kinetic experiments were selected under vapor pressure boundaries as follows: 4.5 MPa for CH<SUB>4</SUB>, 0.75 MPa for SF<SUB>6</SUB>, and 0.16 MPa for HFC-134a at 258.15 K (assuming the use of LNG waste cold energy). The results of the formation kinetics on the basis of gas moles consumed for hydrates showed the order CH<SUB>4</SUB> > HFC-134a > SF<SUB>6</SUB>; however, after considering the hydration numbers and structures for each hydrate, surprisingly, the conversion rate of water to gas hydrates showed the order HFC-134a > CH<SUB>4</SUB> > SF<SUB>6</SUB>, even though the experimental pressure condition for HFC-134a was very mild (0.16 MPa) compared to CH<SUB>4</SUB> (4.5 MPa). For this interesting phenomenon, we suggest a possible mechanism through visual observations during hydrate formation. We believe these thermodynamic, kinetic, and morphological results show potential as an alternative desalination technology, especially for saturated salinity water, with lower energy consumption.</P> <P><B>Highlight</B></P> <P> <UL> <LI> Thermodynamics and kinetics of gas hydrates were studied in saturated NaCl system. </LI> <LI> Using LNG waste cold energy was assumed for hydrate formation kinetics experiments. </LI> <LI> HFC-134a hydrates in saturated NaCl system formed at 0.16 MPa and 258.15 K. </LI> <LI> The kinetics of hydrates conversion showed the order HFC-134a > CH<SUB>4</SUB> > SF<SUB>6</SUB>. </LI> <LI> HBD process with HFC-134a is possibly economic in over-saturated salinity system. </LI> </UL> </P>
Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis
( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2
Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)