Neuroprotective Effects of Lacosamide in Experimental Peripheral Nerve Injury in Rats : A Prospective Randomized and Placebo-Controlled Trial

Demiroz, Serdar,Ur, Koray,Bengu, Aydin Sukru,Ulucan, Aykut,Atici, Yunus,Erdogan, Sinan,Cirakli, Alper,Erdem, Sevki The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.2

Objective : To evaluate the neuroprotective effects of lacosamide after experimental peripheral nerve injury in rats. Methods : A total of 28 male wistar albino rats weighing 300-350 g were divided into four groups. In group I, the sciatic nerve exposed and the surgical wound was closed without injury; in group II, peripheral nerve injuries (PNI) was performed after dissection of the nerve; in group III, PNI was performed after dissection and lacosamide was administered, and in group IV, PNI was performed after dissection and physiological saline solution was administered. At 7 days after the injury all animals were sacrificed after walking track analysis. A 5 mL blood sample was drawn for biochemical analysis, and sciatic nerve tissues were removed for histopathological examination. Results : There is low tissue damage in lacosamide treated group and antioxidant anzymes and malondialdehyde levels were higher than non-treated and placebo treated group. However there was no improvement on clinical assessment. Conclusıon : The biochemical and histological analyses revealed that lacosamide has neuroprotective effect in PNI in rats. This neuroprotective capacity depends on its scavenger role for free oxygen radicals by increasing antioxidant enzyme activity.

The Effects of Fiber Type, Elastane (El) Usage, and Knit Structure on the Moisture Management Properties of Sandwich-Type Double-Face Knitted Fabrics

Ahu Demiroz Gun,Mehmet Akincali,Eren Oner 한국섬유공학회 2023 Fibers and polymers Vol.24 No.10

Moisture management is one of the significant components specifying the thermo-physiological comfort level of fabrics. One of the approaches of making moisture management fabric is to use double-face knitted construction with the combination of hydrophobic fiber type on inner fabric face and hygroscopic fiber type on outer fabric face. While hydrophobic inner face helps to transfer liquid moisture from skin to outer face with capillary action, hygroscopic outer face absorbs liquid moisture and spreads it over greater area on outer face to facilitate evaporation. For a fabric, esthetic appearance is also as important as comfort properties. In this study, to fulfill functional and esthetic performance expectations, particular variants of sandwich-type double-face knitted fabrics are designed in four different knit structures by combining polyester (P), cotton (Co), viscose (V), and modal (M) yarns, V fiber-blended yarns consisting of mixtures of V fibers with silk (S), wool (W) or P fibers, and El yarn in fabric layers; and then the effects of the fiber type, the El usage, and the knit structure on the moisture management behaviors of these fabrics are evaluated. As knit structure, the different combinations of plain single jersey and tuck including single lacoste knit structures on the inner and outer faces of fabrics are considered. Regarding the fiber type effect on the grading values of moisture management indexes, the fabrics comprising the inner face of P fiber and the outer face of Co, V, and M fibers are categorized as moisture management fabrics in excellent (5) grade. The moisture management grades of the fabrics with the El yarn take place in very good (4) to excellent category (5). When the effect of the knit structure is considered, it is seen that all the sandwich double-face fabrics having tucks on their faces fall into good (3) to very good (4) category in terms of moisture management grades.

Intraspinal Anomalies in Individuals with Scheuermann’s Kyphosis: Is the Routine Use of Magnetic Resonance Imaging Necessary for Preoperative Evaluation?

Serdar Demiroz,Ismail Emre Ketenci,Hakan Serhat Yanik,Samet Bayram,Koray Ur,Sevki Erdem 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.4

Study Design: Retrospective study. Purpose: This study aimed to determine the incidence of intraspinal pathologies (ISPs) in individuals with Scheuermann’s kyphosis (SK) and to validate whether the routine use of magnetic resonance imaging (MRI) is necessary for preoperative evaluation. Overview of Literature: There are several studies on the necessity of routine MRI screening and prevalence of ISPs related to different types of scoliosis have been conducted. However, despite the well-established association between ISPs and a higher risk for neurological complications there is no any study on the scientific literature concerning the prevalence of ISPs in patients with SK has been conducted. Methods: The database of the institution was retrospectively reviewed to identify all patients diagnosed with SK who underwent surgery between 2012 and 2015. Patients were excluded from the study if their hospital database records did not include spinal images, which are routinely collected before surgery. The presence or absence of ISPs, as indicated on magnetic resonance images, was evaluated by a radiologist. Results: Of the 138 potential participants, 120 were included in the study. Of these, seven patients (5.8%) had ISPs, and all the cases involved syringomyelia. None of the seven patients with ISPs required additional neurosurgical procedures before corrective surgery. No complications were reported during the perioperative period, and none of the patients developed postoperative neurological deficits. Conclusions: According to this study, the incidence rate of ISPs in patients with SK was 5.8%, and we recommend that all patients with SK should be evaluated using MRI of the spine before corrective surgery.

Improving locoregional outcome in high-intermediate-risk and high-risk stage I endometrial cancer with surgical staging followed by brachytherapy

Candan Demiroz Abakay,Sonay Arslan,Meral Kurt,Sibel Cetintas 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.2

Purpose: This study aims to assess the locoregional efficacy of postoperative vaginal brachytherapy (VBT) alone in patients undergoing surgical staging for early-stage high-intermediate-risk (HIR) and high-risk (HR) endometrial cancer. Materials and Methods: One hundred and four patients with early-stage HIR and HR endometrial cancer who underwent surgical staging were treated with adjuvant VBT alone. The patients with stage Ib, grade I-III, stage Ia, grade III, lower uterine segment involvement, and lymphovascular invasion (LVI) were included to study. Results: The 5- and 10-year overall survival (OS) rates were 87% and 76%, respectively. The 5- and 10-year DFS rates were 86% and 86%, respectively. Among the patients, 92% had endometrioid adenocarcinoma, 2% had undifferentiated carcinoma, 2% had serous papillary carcinoma, and 4% had clear-cell carcinoma. Of the patients, 63% had stage Ib disease, while 37% had stage Ia disease. None of the patients had vaginal or pelvic lymph node recurrence, whereas two had para-aortic lymph node metastasis, one had surgical scar recurrence, one had para-aortic lymph node and brain metastasis, and one had lung metastasis. The presence of lymphatic invasion was found to be a statistically significant prognostic factor for increased distant metastasis rates (p = 0.020). Lymphatic invasion was also regarded as an independent prognostic factor for metastasis-free survival (p = 0.044). Conclusion: Our study results suggest that postoperative VBT alone is an effective and safe treatment modality with low complication in patients undergoing surgical staging for HIR and HR endometrial cancer.

Thermo-physiological Comfort Performance of Recycled Plain Knitted Fabrics Produced from Acrylic Waste Fiber with the Effects of Incorporated Covered and PBT Elastic Yarns

Ahu Demiroz Gun,Cemre Nur Kuyucak 한국섬유공학회 2022 Fibers and polymers Vol.23 No.9

The objective of this work is to evaluate the thermo-physiological comfort performance properties of the recycledacrylic plain knitted fabrics produced from recycled open end yarn including acrylic waste fiber in comparison with those ofequivalent virgin acrylic counterparts, considering the effects of incorporated covered and PBT elastic yarns. Acrylic fiber ischaracterized by possessing wool-like handle and thermal comfort characteristics, which makes acrylic waste fiber goodcandidate for sweater-like knitted fabric applications worn in cold weather conditions. Covered polyester/lycra and PBTelastic yarns are included into the study to give added value to the recycled fabrics. Comparing the thermo-physiologicalproperties of the recycled and virgin acrylic fabrics, it is observed that in the recycled acrylic fabrics, thermal conductivityand thermal absorptivity are found to be lower, whereas thermal resistance is higher. These thermal values make recycledacrylic fabrics appropriate for cold weather. Regarding to elastic yarn state, the addition of either the covered yarn or the PBTyarn leads to increase in the thermal conductivity, thermal resistance and thermal absorptivity properties and the covered yarntends to affect the thermal parameters more than the PBT yarn. The lowest air permeability and water vapor permeabilityresults are achieved for the fabrics with the covered yarn.

Performance Properties of Plain Knitted Fabrics Made from Open End Recycled Acrylic Yarn with the Effects of Covered and PBT Elastic Yarns

Ahu Demiroz Gun,Cemre Nur Kuyucak 한국섬유공학회 2022 Fibers and polymers Vol.23 No.1

In this research, the performance properties of plain knitted fabrics made from open end recycled and virgin acrylicyarns are comparatively investigated, together with the effects of added covered and PBT elastic yarns. The previous studiesabout the recycling of textile wastes and their usage were mainly focussed on waste type including cotton fibre. Althoughacrylic textile wastes constitute one of the most common recycled waste types after cotton wastes, there have been no studieson the usage of this type of waste as a fabric form in the literature. The recycled acrylic yarn is spun from 100 % acrylic fibrewastes subjected to mechanical recycling process of garneting. Covered and PBT elastic yarns are incorporated to give anadded value to the recycled acrylic fabrics. The experimental and statistical results reveal that the fibre type (acrylic wastefibre and virgin acrylic fibre) and the elastic yarn state (addition and type) parameters affect all the performance properties ofthe fabrics significantly. The recycled acrylic fabrics exhibit higher thickness, pilling tendency, abrasion resistance andcoursewise extension results and lower bursting strength results than the corresponding virgin acrylic fabrics. As far as theelastic yarn state is considered, it is observed that the fabrics with the covered yarn reveal the highest stitch density, mass,thickness and walewise extension results, followed by the fabrics with the PBT yarn. The highest bursting strength and thelowest pilling tendency results are obtained for the fabrics with the PBT yarn. Addition of the elastic yarn improves theabrasion resistance of the recycled and virgin acrylic fabrics. No statistically significant difference is found between theabrasion results of the recycled acrylic fabrics with the covered yarn and the PBT yarn.

Role of PET/CT in Treatment Planning for Head and Neck Cancer Patients Undergoing Definitive Radiotherapy

Arslan, Sonay,Abakay, Candan Demiroz,Sen, Feyza,Altay, Ali,Akpinar, Tayyar,Ekinci, Ahmet Siyar,Esbah, Onur,Uslu, Nuri,Kekilli, Kezban Esra,Ozkan, Lutfi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Background: In this study, we aimed to investigate the benefits of 18F-deoxyglucose positron emission tomography/computed tomography (FGD-PET/CT) imaging for staging and radiotherapy planning in patients with head and neck cancer undergoing definitive radiotherapy. Materials and Methods: Thirty-seven head and neck cancer patients who had undergone definitive radiotherapy and PET/CT at the Uludag University Medical Faculty Department of Radiation Oncology were investigated in order to determine the role of PET/CT in staging and radiotherapy planning. Results: The median age of this patient group of 32 males and 5 females was 57 years (13-84years). The stage remained the same in 18 cases, decreased in 5 cases and increased in 14 cases with PET/CT imaging. Total gross tumor volume (GTV) determined by CT (GTVCT-Total) was increased in 32 cases (86.5%) when compared to total GTV determined by PET/CT (GTVPET/CT-Total). The GTV of the primary tumor determined by PET/CT (GTVPET/CT) was larger in 3 cases and smaller in 34 cases compared to that determined by CT (GTVCT). The GTV of lymph nodes determined by PET/CT (GTVLNPET/CT) was larger in 20 cases (54%) and smaller in 12 cases (32.5%) when compared to GTV values determined by CT (GTVLNCT). No pathological lymph nodes were observed in the remaining five cases with both CT and PET/CT. Conclusions: We can conclude that PET/CT can significantly affect both pretreatment staging and assessed target tumor volume in patients with head and neck cancer. We therefore recommend examining such cases with PEC/CT before treatment.

Effects of soil-structure interaction on construction stage analysis of highway bridges

Sevket Ates,Barbaros Atmaca,Erdal Yildirim,Nurcan Asci Demiroz 사단법인 한국계산역학회 2013 Computers and Concrete, An International Journal Vol.12 No.2

The aim of this paper is to determine the effect of soil-structure interaction and time dependent material properties on behavior of concrete box-girder highway bridges. Two different finite element analyses, one stage and construction stage, have been carried out on Komurhan Bridge between Elazığ and Malatya province of Turkey, over Fırat River. The one stage analysis assume that structure was built in a second and material properties of structure not change under different loads and site conditions during time. However, construction stage analysis considers that construction time and time dependent material properties. The main and side spans of bridge are 135 m and 76 m, respectively. The bridge had been constructed in 3 years between 1983 and 1986 by balanced cantilever construction method. The parameters of soil-structure interaction (SSI), time dependent material properties and construction method are taken into consideration in the construction stage analysis while SSI is single parameter taking into consideration in the one stage analysis. The 3D finite element model of bridge is created the commercial program of SAP2000. Time dependent material properties are elasticity modulus, creep and shrinkage for concrete and relaxation for steel. Soft, medium, and firm soils are selected for evaluating SSI in both analyses. The results of two different finite element analyses are compared with each other. It is seen that both construction stage and SSI have a remarkable effect on the structural behavior of the bridge.

Can Breast Asymmetry Following the Treatment of Juvenile Idiopathic Scoliosis with Growing Rod Be Prevented? : A Preliminary Analysis

Atici, Yunus,Polat, Baris,Erdogan, Sinan,Gurpinar, Tahsin,Demiroz, Serdar The Korean Neurosurgical Society 2020 Journal of Korean neurosurgical society Vol.63 No.2

Objective : It can be assumed that the progression of scoliosis in the juvenile period will increase the asymmetry in the rib cage, and thus will contribute to an increase in the breast asymmetry (BA) in the future. We are looking for answers to the questions; "How will the breasts look with respect to each other and what is the possibility of developing BA in the early follow-up period following the early surgical treatment and final fusion surgery of juvenile idiopathic scoliosis (JIS)?" For this reason, in this study, we aimed to evaluate the breast asymmetries of patients in the period after the final fusion. Methods : Following growing rod treatment, final fusion was achieved in 12 females with JIS. We used the anthropomorphic measurement of the modified BREAST-V formula to assess whether there was an asymmetry between the breasts after an average of 4.8 years (2-11) following final fusion. Results : In comparison, the mean volume of the left breast (222.4 mL [range, 104.1-330.2]) was larger than the mean volume of the right breast volume (214.5 mL [range, 95.2-326.7]) (p=0.034). The left breast was larger in 75% of the patients. BA was observed in 50% of the patients. No correlation was detected between the Cobb angle of the patient after final fusion and BA (p=0.688). Conclusion : In the late follow-up period, BA was detected in 50% of the patients with JIS who achieved final fusion after treatment with growing rod. In majority of the patients, left breast was larger. The patients with JIS and their families can be informed prior to the operation about the probability of BA seen in the follow-up period after fusion.