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RISS 인기검색어
- 검색키워드
- 저자 : Defang Zhao (검색결과 4 건)
- 무료
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Defang Zhao,Wei Wang,Zongzi Hou 한국섬유공학회 2019 Fibers and polymers Vol.20 No.1
Mechanical properties and failure behavior of glass plain-weave fabric composites under on-axis (i.e. 0 and 90 o direction) and off-axis (i.e. θ=5, 10, 15, 30, 45 and 60 o) tensile loading conditions have been experimentally investigated. Acoustic emissions (AE) monitoring and step-by-step optical observation with interrupted tension tests were adopted to study the character and failure mechanisms of various fiber orientations. The experimental results indicate that both off-axis elasticmodulus and strength degrade with increasing off-axis angle in all cases. There is a good agreement for the axial modulus Ex between the experimental results and theory results obtained from orthotropic linear elasticity theory. Adoption of the principal shear strength S45°=28.5 MPa which is evaluated using the tensile strength based on the 45 o specimen allows better predictions of the off-axis tensile strengths by means of the Tsai-Hill failure criterion. Off-axis specimens exhibit lower kneepoint stress than on-axis ones and initial fracture strain monitored by AE (>75 dB) has a good fit to knee-point strain in this study. Tensile strength exhibits an increased tendency toward the delay of initial fracture behavior.
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Defang Zhao,Lichao Yu,Weiwei Guo,Xu Meng,Yinjiang Zhang,Haihua Zhan,Jianhan Hong,Huaizhong Xu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4
This paper reports a detailed study on the long-term mechanical and dynamic mechanical performance of carbonfiber (CF) plain-woven fabric-reinforced epoxy (CF/epoxy) laminates fabricated by the hot-compression molding technique. Water-sorption experiments, mechanical property tests, and dynamic mechanical analysis (DMA) tests were performed afterimmersion in de-ionized water at different temperatures (i.e., 25 oC, 60 oC, and 80 oC) for times up to 120 days. The resultsshow that weight-gain curves for the composites at elevated temperature (i.e., 80 oC) fit the theoretical Fickian diffusion curveduring the initial immersion time, but deviate substantially as time prolongs. The flexural properties and dynamic mechanicalproperties are highly susceptible to the effects of the hygrothermal environment, and the performance for both degrade withincreasing exposure temperatures and durations. The dynamic mechanical properties partly recover after the dryingtreatment, which is caused by the irreversible degradation in the interfacial region (i.e., fiber/matrix debonding) as evidencedby morphological images from scanning electron microscopy (SEM). Finally, the long-term degradation of the compositeswas estimated and the service life of the materials was also predicted using the Arrhenius degradation theory. The outputs ofthe research show that CF/epoxy laminates have flexural strength retention of 60 % for more than 2 years at the annualtemperature of Kyoto.
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CKS1B promotes the progression of hepatocellular carcinoma by activating JAK/STAT3 signal pathway
Xitao Liu,Defang Zhao 한국통합생물학회 2021 Animal cells and systems Vol.25 No.4
Hepatocellular carcinoma (HCC) is a malignancy of considerable concern due to its continuous increase in morbidity and mortality. This study attempts to identify the molecules that play a key role in the progression of HCC, explore its potential mechanism, and provide more target choices for targeted therapy. Using overexpression plasmid and shRNA, CKS1B was respectively overexpressed and knocked down to explore its biological function roles in HCC progression and development. MTT and colony formation assays showed that knockdown of CKS1B inhibited the survival and proliferation of HCC cell lines (Hep3B and Huh7). The flow cytometry and western blot analysis showed that knockdown of CKS1B significantly induced the apoptosis of Hep3B and Huh7 cells. The wound healing and transwell invasion assays showed that knockdown of CKS1B had a significant inhibitory effect on the migration and invasion of Hep3B and Huh7 cells. These functional tests confirmed that CKS1B acts as an oncogene that regulates the malignant progression of HCC. Moreover, this study also demonstrated that knockdown of CKS1B inhibited the activation of JAK/STAT3 pathway, evidenced by the significantly downregulated p-STAT3 protein expression. Furthermore, knockdown of CKS1B also downregulated STAT3 target genes TIMP-1, Bcl-2 and VEGF, which were involved in controlling cell apoptosis and migration. On the contrary, overexpression of CKS1B caused the completely opposite results. Taken together, CKS1B acts as an oncogene to promote the proliferation and metastasis of HCC cells by activating JAK/STAT3 signaling pathway.
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Yuanyi Shao,Masaya Matsushita,Yang Yang,Akio Ohtani,Defang Zhao,Ruohua Liu,Yuqiu Yang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.5
In this work, nonwoven fabrics made from carbon fibers (CFs) and polypropylene (PP) fibers were manufacturedthrough a carding process and a cross-laying process and reinforced by either a needle punching method or a thermobondingmethod. The effects of the carding parameters (adding oil, increasing the gauge and decelerating the speed) andreinforcement method (needle punching method or thermobonding method) on the anisotropic mechanical properties of hotpressedCF/PP composites were investigated. Additionally, the length, distribution and orientation of carbon fibers in the hotpressedcomposites were studied. The carbon fibers were oriented by the carding method, and the composites exhibitedanisotropic properties. Moreover, the fiber distribution results indicated that increasing the gauge and decelerating the speedhad a slightly negative influence on the distribution of carbon fibers and that the cross-laying process led to a uniformdistribution of fibers. Furthermore, adjusting the carding parameters and reinforcement method could reduce the damagesustained by carbon fibers during manufacturing and subsequently improve the mechanical properties of the CF/PPcomposites in the transverse direction (TD).
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