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Lisha K. P.,Debasis Sarkar 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.5
This study presents a detailed in silico analysisof bioethanol production from glucose/xylose mixtures ofvarious compositions by fed-batch co-culture and monoculturefermentation of specialized microbes. The monocultureconsists of recombinant Saccharomyces cerevisisethat can metabolize both hexose and pentose sugars whilethe co-culture system consists of substrate-selective microbes. Dynamic flux balance models based on available genomescalereconstructions of the microorganisms have beenused to analyze bioethanol production in fed-batch culturewith constant feed rates and the maximization of ethanolproductivity is addressed by computing optimal aerobicanaerobicswitching times. The simulation results clearlypoint to the superior performance of fed-batch fermentationof microbial co-culture against fed-batch fermentation ofmono-culture for bioethanol production from glucose/xylosemixtures. A set of potential genetic engineering strategiesfor enhancement of S. cerevisiae and Escherichia colistrains performance have been identified. Such in silicopredictions using genome-scale models provide valuableguidance for conducting in vivo metabolic engineeringexperiments.