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Valentin Oleksik,Adrian Pascu,Cristian Deac,Radu Fleaca,Mihai Roman,Octavian Bologa 한국소성가공학회 2010 기타자료 Vol.2010 No.6
In this paper the authors intend to examine by numerical simulation one of the newest methods for obtaining the knee condylar surface, namely by incremental forming starting from a commercially pure titanium (CP Ti) sheet. In order to study the influence of the geometrical parameters, the authors chose to vary the material thickness, the punch diameter and the vertical step of the punch. Two different values of the hemispherical punch diameter (d = 4 and 6 mm), two different initial thicknesses of the blank (t = 1 and 1.2 mm) and two different vertical step values (s = 0.6 and 1 mm) are taken into consideration. The numerical results of the simulations were centered on determining the thinning of the sheet, the major principal strain, the springback, the process forces and the manner in which these are influenced by the geometrical parameters that were varied.
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Al Hussein Hussam,Al Hussein Hamida,Sircuta Carmen,Cotoi Ovidiu S.,Movileanu Ionela,Nistor Dan,Cordos Bogdan,Deac Radu,Suciu Horatiu,Brinzaniuc Klara,Simionescu Dan T.,Harpa Marius M. 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.6
Background: Development of valvular substitutes meeting the performance criteria for surgical correction of congenital heart malformations is a major research challenge. The sheep is probably the most widely used animal model in heart valves regenerative medicine. Although the standard cardiopulmonary bypass (CPB) technique and various anesthetic and surgical protocols are reported to be feasible and safe, they are associated with significant morbidity and mortality rates. The premise of this paper is that the surgical technique itself, especially the perioperative animal care and management protocol, is essential for successful outcomes and survival. Methods: Ten juvenile and adult female sheep aged 7.8–37.5 months and weighing 32.0–58.0 kg underwent orthotopic implantation of tissue-engineered pulmonary valve conduits on beating heart under normothermic CPB. The animals were followed-up for 6 months before scheduled euthanasia. Results: Based on our observations, we established a guide for perioperative care, follow-up, and treatment containing information regarding the appropriate clinical, biological, and ultrasound examinations and recommendations for feasible and safe anesthetic, surgical, and euthanasia protocols. Specific recommendations were also included for perioperative care of juvenile versus adult sheep. Conclusion: The described surgical technique was feasible, with a low mortality rate and minimal surgical complications. The proposed anesthetic protocol was safe and effective, ensuring both adequate sedation and analgesia as well as rapid recovery from anesthesia without significant complications. The established guide for postoperative care, follow-up and treatment in sheep after open-heart surgery may help other research teams working in the field of heart valves tissue regeneration.
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