교정적 치아이동시 부갑상선홀몬이 긴장측 치주세포의 cAMP농도에 미치는 영향

Davidovitch, Z.,Lanese,R.R.,Schanfeld, J.L.,Zwilling, B.S.,이기수 대한치과교정학회 1986 대한치과교정학회지 Vol.16 No.1

Parathyroid hormone (PTH) is known to exert its effects on bone cells through the mediation of adenosine 3', 5'-monophosphate (cAMP). Orthodontic force have also been shown to alter the cAMP content of paradental cells, particularly the alveolar bone osteoblasts. The objective of this experiment was to determine whether a combined orthodontic treatment-PTH administration regimen would have an additive effect on cAMP content in paradental cells in sites of periodontal logament (PDL) tension. Seven groups of 4 one year old female cats each were treated for 1,3,6,12,24 h, 7 and 14 d by tipping one maxillary canine. PTH was administered twice daily, 30u/kg. Maxillary horizontal sections were stained immunohistochemically for cAMP and the degree of cellular staining intensity was determined microphotometrically as per cent light transmittance at 600nm. Alveolar bone osteoblasts, progenitor cells, PDL fibroblasts and cementoblasts in tenion sites were measured and the data were analyzed statistically by a mixed model analysis of variance. PTH administration increased the cAMP staining of nonorthodontically treated paradental ceels in comparison to ceels untreated by force or hormone. Cells in PDL tension sites of PTH-treated cats demonstrated significantly darker cAMP staining than cells in non-orthodonticaaly-treated sites. Osteoblasts demonstrated the greatest respons in terms of cAMP elevation, while in PDL fibroblasts orthodontic force did not increase cAMP levels above those measured in non-stretched hormonally-treated cells. These results demonstrate that PTH increases cAMP levels in paradental cells, particullarly in osteoblasts, and that tje effects of PTH and orthodontic forces on paradental target cells may approach additivity.

Alopecia : An unexpected effect of orthodontic treatment

Davidovitch, Ze'ev,Lee, Young Jun,Chung, Kyu Rhim,Park, Young Guk,Matkovic, Velimir 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.6

이 증례 보고는 치조성 Ⅱ급 1류 부정교합의 해결을 위한 통상적 교정치료 중 탈모를 보인 청소년기 환자에 대한 것이다. 22개월 간 지속된 교정치료의 결과는 성공적이었다. 그러나 치료 시작 8개월 후 환자는 완전 완전탈모현상을 보엮다. 환자에 대한 포괄적인 의학적 검사와 감별진당은 교정치료에 의하여 유발된 심리적 스트레스로 그 원인을 결론지였다. 다수 선학들의 보고에서 심리적 스트레스는 면역체계에 영향을 줌으로써 탈모를 유발할 수 있다고 지적하고 있다. 따라서 이 증례의 경우 면역체계에 대한 스트레스의 결과 두피 모낭 중위의 조직에 대한 자동명역질환과 유사한 상태가 초래됨으로써 탈모가 발생한 것으로 추정함이 타당할 것으로 생각된다, 환자의 탈모는 비티민 D의 경구 및 경피적 투여로 완전 치유되었다. 이러한 증레는 면역체계야 말로 치아주위조직의 개조를 위항 중주적 역할을 담당하며, 면역체계에 영향을 줄 수 있는 어떠한 상태도 교정치료시 탈모의 발생 등과 같은 예기치 않은 결과를 초래할 수 있음을 시사한다. A case is described, where an adolescent boy developed alopecia areata and alopecia totalis during the course of routine orthodotic treatment for the resolution of a dentoalveolar Class Ⅱ dicision 1 malocclusion. the orthodontic treatment lasted 22 months, with a successful coutcome. However, within eight months of the onset of treatment the patient lost all his hair. Exhaustive mrdical tests and differential diagnosis determined that the etiolgy of the patient's alopecia was psychological stress evoked by the orthodontic treatment. Numerous reports suggest that psychological stress can cause alopecia by affecting the immune system. Therefore, it appears reasonable to assume that in the case of this patient, alopecia had resulted from stress effects on the immune system, leading to autoimmune disease-like conditions in tissues surrounding the scalp hair follicles. The alopecia condition was successfully reversed by daily oral and topical applications of vitamin D. It is concludrd that the immune system plays a pivotal role in tissue remodeling around the teeth and elsewhere in the body, and that any condition capable of affecting this system may cause unfavorable cutcomes, such as alopecia.

교정적 치아이동시 부갑상선홀몬이 긴장측 치주세포의 cAMP농도에 미치는 영향

Davidovitch, Zeev,Lee, Ki-Soo,Zwilling, Bruce S.,Lanese, Richard R.,Schanfeld, Joseph L. 대한치과교정학회 1986 대한치과교정학회지 Vol.16 No.1

Parathyroid hormone (PTH) is known to exert its effects on bone cells through the mediation of adenosine 3', 5'-monophosphate (cAMP). Orthodontic forces have also been shown to alter the cAMP content of paradental cells, particularly the alveolar bone osteoblasts. The objective of this experiment was to determine whether a combined orthodontic treatment-PTH administration regimen would have an additive effect on cAMP content in paradental cells in sites of periodontal ligament (PDL) tension. Seven groups of 4 one year old female cats each were treated for 1,3,6,12,24 h, 7 and 14 d by tipping one maxillary canine. PTH was administered twice daily, 30u/kg. Maxillary horizontal sections were stained immunohistochemically for cAMP and the degree of cellular staining intensity was determined microphotometrically as per cent light transmittance at 600nm. Alveolar bone osteoblasts, progenitor cells, PDL fibroblasts and cementoblasts in tenion sites were measured and the data were analyzed statistically by a mixed model analysis of variance. PTH administration increased the cAMP staining of nonorthodontically treated paradental cells in comparison to cells untreated by force or hormone. Cells in PDL tension sites of PTH-treated cats demonstrated significantly darker cAMP staining than cells in non-orthodontically-treated sites. Osteoblasts demonstrated the greatest response in terms of cAMP elevation, while in PDL fibroblasts orthodontic force did not increase cAMP levels above those measured in non-stretched hormonally-treated cells. These results demonstrate that PTH increases cAMP levels in paradental cells, particullarly in osteoblasts, and that the effects of PTH and orthodontic forces on paradental target cells may approach additivity.

Alopecia: An unexpected effect of orthodontic treatment

Ze"ev Davidovitch(제프 다비도비치),Young Jun Lee(이영준),Kyu Rhim Chung(정규림),Young Guk Park(박영국),Velimir Matkovic(벨리머 맷코빅) 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.6

초소형 전기 장치에 의한 전기 자극이 치아 이동과 주위 조직 개조에 미치는 효과에 관한 연구

박순정,이영준,박영국,Davidovitch, Zeev 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.4

낮은 강도의 전류는 골세포의 활성화 대사를 증가시키는 것으로 알려져 왔다. 이 연구는 초소형 전기 장치에 의한 전기 자극이 교정적 치아 이동에 미치는 영향을 규명하기 위하여, 체중 3kg 내외의 고양이 6마리를 대상으로 가철성 교정 장치와 NiTi coil spring(75gm)을 사용하여 상악 견치를 이동시켰다. 실험군측 견치에는 교정력과 간헐적인 20㎂의 전기 자극을 가하였고, 대조군측에는 같은 크기의 교정력만을 가한 후 4주 동안의 치아 이동량을 측정하여 비교하였으며, 치아를 중심으로 조직을 절취하여 탈회하고 조직 처리 후 광학 현미경으로 치주조직의 변화를 비교하여 다음과 같은 결론을 얻었다. 1. 28일간의 실험 기간 동안 실험측의 치아 이동량은 대조군에 비하여 현저히 증가하여, 4주후에 실험측의 치아는 대조군에 비하여 37% 증가된 이동량을 기록하였다. 2. 전기 자극을 받은 치아의 치근 견인측에서 대조군에 비하여 조직학적으로 증가된 골형성 양상이 관찰되었다. 3. 28일간의 전기 자극과 교정력으로 실험측 치아의 압박측에서 대조군에 비하여 증가된 골 흡수 양상이 관찰되었다. 4. 실험군 견치 치근 주위 조직에서는 전반적으로 더 많은 수의 조골 및 파골 세포들과 모세 혈관, 골양 조직들이 관찰됨으로써 증가된 조직 세포 활성을 반영하였다. 5. 1일 5시간 동안의 간헐적 전류 자극은 치아 이동량을 증가 시키고 조직 개조를 활성화 시키는 효과가 있었다. 이상의 결과는 외부에서 가한 낮은 강도의 간헐적 전기 자극으로 교정적 치아 이동량이 많아지고 치주 조직의 개조활성이 증가됨을 보이므로 초소형 전기 장치에 의한 자극은 치아 이동과 주위 조직 개조를 촉진시킬 가능성이 있을 것으로 평가 되었다. Electric current is a highly probable way as a clinical tool for tooth movement. The purposes of this study were to determine the usefulness of exogenous electric currents in accelerating orthodontic tooth movement and to investigate the effects of electric-orthodontic treatment on the remodeling of the periodontal tissue histologically. The study was performed with six male cats weighing around 3kg. The electric device which is providing the direct electric current of 20㎂ was inserted to the removable appliance. The right and left maxillary canines were assigned as control and experimental sides respectively. The control canine was provided with orthodontic force (75gm) only and the experimental side was given the same amount of force and electricity. The lingual buttons were bonded to the maxillary canines and both sides of canines were retracted with NiTi coil spring. The electric device was adjusted to provide 20㎂ direct current to the experimental canines 5 hours a day. The amount of the canine movement was measured with electronic caliper every week. After4 weeks of tooth movement, the animals were sacrificed and the histologic study was performed. The results of this study were as follows : 1. The application of a direct current to the experimental tooth significantly increased the final amount of orthodontic tooth movement. The amount of tooth movement after 28-day was 37% more in the experimental side. 2. The electrically stimulated tooth showed histologic evidence of significant increases in the amount of bones and matrix deposition in the area of tension. 3. In the compression side, the electric-orthodontic treatment stimulated bone resorption more extensively in the experimental canines. 4. After 28 days of electricity exposure and orthodontic force, the experimental side demonstrated significantly more osteoblasts, osteoclasts, capillaries and osteoid tissues, reflecting an increase in the local tissue's cellular activity. 5. Intermittent electrical stimulation (five hours a day) had effects to enhance orthodontic tooth movement and tissue remodeling. These results suggested that the low-intensity exogenous electric current by the miniature electric device might accelerate orthodontic tooth movement and bone remodeling in vivo and have the possibility to reduce the orthodontic treatment duration.

교정치료와 관련된 치근흡수와 천식, 앨러지 및 심리적 스트레스와의 상관성에 관한 연구

심연수 ( Youn Soo Shim ),제프다비도비치 ( Ze`ev Davidovitch ) 한국치위생과학회 2003 치위생과학회지 Vol.3 No.1