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      • KCI등재

        Botulinum Toxin Therapy versus Anterior Belly of Digastric Transfer in the Management of Marginal Mandibular Branch of the Facial Nerve Palsy: A Patient Satisfaction Survey

        Daniel P Butler,,Jo I Leckenby,Ben H Miranda,Adriaan O Grobbelaar 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.6

        Background Botulinum toxin (BT) chemodenervation and anterior belly of digastric muscle (ABD) transfer are both treatment options in the management of an isolated marginal mandibular branch of the facial nerve (MMB) palsy. We compare the patient satisfaction following either BT injections or ABD transfer in the management of their isolated MMB palsy. Methods Patients in the ABD-arm of the study were identified retrospectively from September 2007 to July 2014. The patients in the BT-arm of the study were identified prospectively from those attending the clinic. Both groups of patients completed a validated patient satisfaction survey. Statistical analysis was performed and a P-value <0.05 was considered statistically significant. Results Seven patients were in the ABD-arm and 11 patients in the BT-arm of the study. The patient satisfaction in both groups was high with 45% of ABD-arm patients and 40% of BTarm patients rating their overall outcome as ‘better’ or ‘much better’, which was significantly more than the proportion rating their outcome as ‘worse’ or ‘much worse’ (P<0.001), although there was a significant trend towards those in the ABD-arm being more likely to be dissatisfied with their outcome (P=0.01). Conclusions BT therapy is a good first-line intervention in the management of isolated MMB palsy. We have, however, shown that the overall satisfaction in both groups is high. Therefore, in patients who would prefer a more permanent solution to manage their facial asymmetry, ABD transfer remains a satisfactory treatment option with a good level of patient satisfaction.

      • SCOPUSKCI등재

        Botulinum Toxin Therapy versus Anterior Belly of Digastric Transfer in the Management of Marginal Mandibular Branch of the Facial Nerve Palsy: A Patient Satisfaction Survey

        Butler, Daniel P,Leckenby, Jo I,Miranda, Ben H,Grobbelaar, Adriaan O Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.6

        Background Botulinum toxin (BT) chemodenervation and anterior belly of digastric muscle (ABD) transfer are both treatment options in the management of an isolated marginal mandibular branch of the facial nerve (MMB) palsy. We compare the patient satisfaction following either BT injections or ABD transfer in the management of their isolated MMB palsy. Methods Patients in the ABD-arm of the study were identified retrospectively from September 2007 to July 2014. The patients in the BT-arm of the study were identified prospectively from those attending the clinic. Both groups of patients completed a validated patient satisfaction survey. Statistical analysis was performed and a P-value <0.05 was considered statistically significant. Results Seven patients were in the ABD-arm and 11 patients in the BT-arm of the study. The patient satisfaction in both groups was high with 45% of ABD-arm patients and 40% of BT-arm patients rating their overall outcome as 'better' or 'much better', which was significantly more than the proportion rating their outcome as 'worse' or 'much worse' (P<0.001), although there was a significant trend towards those in the ABD-arm being more likely to be dissatisfied with their outcome (P=0.01). Conclusions BT therapy is a good first-line intervention in the management of isolated MMB palsy. We have, however, shown that the overall satisfaction in both groups is high. Therefore, in patients who would prefer a more permanent solution to manage their facial asymmetry, ABD transfer remains a satisfactory treatment option with a good level of patient satisfaction.

      • SCISCIESCOPUS

        Machine learning for molecular and materials science

        Butler, Keith T.,Davies, Daniel W.,Cartwright, Hugh,Isayev, Olexandr,Walsh, Aron Nature Publishing Group UK 2018 Nature Vol.559 No.7715

        <P>Here we summarize recent progress in machine learning for the chemical sciences. We outline machine-learning techniques that are suitable for addressing research questions in this domain, as well as future directions for the field. We envisage a future in which the design, synthesis, characterization and application of molecules and materials is accelerated by artificial intelligence.</P>

      • Computer-aided design of metal chalcohalide semiconductors: from chemical composition to crystal structure

        Davies, Daniel ,W.,Butler, Keith T.,Skelton, Jonathan M.,Xie, Congwei,Oganov, Artem R.,Walsh, Aron Royal Society of Chemistry 2018 Chemical Science Vol.9 No.4

        <▼1><P>The standard paradigm in computational materials science is INPUT: <SMALL>STRUCTURE;</SMALL> OUTPUT: <SMALL>PROPERTIES</SMALL>, which has yielded many successes but is ill-suited for exploring large areas of chemical and configurational hyperspace.</P></▼1><▼2><P>The standard paradigm in computational materials science is INPUT: S<SMALL>TRUCTURE</SMALL>; OUTPUT: P<SMALL>ROPERTIES</SMALL>, which has yielded many successes but is ill-suited for exploring large areas of chemical and configurational hyperspace. We report a high-throughput screening procedure that uses compositional descriptors to search for new photoactive semiconducting compounds. We show how feeding high-ranking element combinations to structure prediction algorithms can constitute a pragmatic computer-aided materials design approach. Techniques based on structural analogy (data mining of known lattice types) and global searches (direct optimisation using evolutionary algorithms) are combined for translating between chemical composition and crystal structure. The properties of four novel chalcohalides (Sn<SUB>5</SUB>S<SUB>4</SUB>Cl<SUB>2</SUB>, Sn<SUB>4</SUB>SF<SUB>6</SUB>, Cd<SUB>5</SUB>S<SUB>4</SUB>Cl<SUB>2</SUB> and Cd<SUB>4</SUB>SF<SUB>6</SUB>) are predicted, of which two are calculated to have bandgaps in the visible range of the electromagnetic spectrum.</P></▼2>

      • KCI등재

        The Axillary Approach to Raising the Latissimus Dorsi Free Flap for Facial Re-Animation: A Descriptive Surgical Technique

        Jonathan Leckenby,Daniel Butler,Adriaan Grobbelaar 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.1

        The latissimus dorsi flap is popular due to the versatile nature of its applications. When usedas a pedicled flap it provides a robust solution when soft tissue coverage is required followingbreast, thoracic and head and neck surgery. Its utilization as a free flap is extensive due to themuscle’s size, constant anatomy, large caliber of the pedicle and the fact it can be used forfunctional muscle transfers. In facial palsy it provides the surgeon with a long neurovascularpedicle that is invaluable in situations where commonly used facial vessels are not available,in congenital cases or where previous free functional muscle transfers have been attempted,or patients where a one-stage procedure is indicated and a long nerve is required to reachthe contra-lateral side. Although some facial palsy surgeons use the trans-axillary approach,an operative guide of raising the flap by this method has not been provided. A clear guide ofraising the flap with the patient in the supine position is described in detail and offers thebenefits of reducing the risk of potential brachial plexus injury and allows two surgical teamsto work synchronously to reduce operative time.

      • SCOPUSKCI등재

        The Axillary Approach to Raising the Latissimus Dorsi Free Flap for Facial Re-Animation: A Descriptive Surgical Technique

        Leckenby, Jonathan,Butler, Daniel,Grobbelaar, Adriaan Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.1

        The latissimus dorsi flap is popular due to the versatile nature of its applications. When used as a pedicled flap it provides a robust solution when soft tissue coverage is required following breast, thoracic and head and neck surgery. Its utilization as a free flap is extensive due to the muscle's size, constant anatomy, large caliber of the pedicle and the fact it can be used for functional muscle transfers. In facial palsy it provides the surgeon with a long neurovascular pedicle that is invaluable in situations where commonly used facial vessels are not available, in congenital cases or where previous free functional muscle transfers have been attempted, or patients where a one-stage procedure is indicated and a long nerve is required to reach the contra-lateral side. Although some facial palsy surgeons use the trans-axillary approach, an operative guide of raising the flap by this method has not been provided. A clear guide of raising the flap with the patient in the supine position is described in detail and offers the benefits of reducing the risk of potential brachial plexus injury and allows two surgical teams to work synchronously to reduce operative time.

      • KCI등재

        Scar Revision Surgery: The Patient’s Perspective

        Benjamin H Miranda,Anna Y Allan,Daniel P Butler,Paul D Cussons 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.6

        Background Insufficient satisfaction outcome literature exists to assist consultations for scar revision surgery; such outcomes should reflect the patient’s perspective. The aim of this study was to prospectively investigate scar revision patient satisfaction outcomes, according to specified patient-selection criteria. Methods Patients (250) were randomly selected for telephone contacting regarding scar revisions undertaken between 2007–2011. Visual analogue scores were obtained for scars preand post-revision surgery. Surgery selection criteria were; ‘presence’ of sufficient time for scar maturation prior to revision, technical issues during or wound complications from the initial procedure that contributed to poor scarring, and ‘absence’ of site-specific or patient factors that negatively influence outcomes. Patient demographics, scar pathogenesis (elective vs. trauma), underlying issue (functional/symptomatic vs. cosmetic) and revision surgery details were also collected with the added use of a real-time, hospital database. Results Telephone contacting was achieved for 211 patients (214 scar revisions). Satisfaction outcomes were ‘2% worse, 16% no change, and 82% better’; a distribution maintained between body sites and despite whether surgery was functional/symptomatic vs. cosmetic. Better outcomes were reported by patients who sustained traumatic scars vs. those who sustained scars by elective procedures (91.80% vs. 77.78%, P=0.016) and by females vs. males (85.52% vs. 75.36%, P<0.05), particularly in the elective group where males (36.17%) were more likely to report no change or worse outcomes versus females (16.04%) (P<0.01). Conclusions Successful scar revision outcomes may be achieved using careful patient selection. This study provides useful information for referring general practitioners, and patient-surgeon consultations, when planning scar revision.

      • SCOPUSKCI등재
      • SCOPUSKCI등재

        An Algorithm to Guide Recipient Vessel Selection in Cases of Free Functional Muscle Transfer for Facial Reanimation

        Henry, Francis P.,Leckenby, Jonathan I.,Butler, Daniel P.,Grobbelaar, Adriaan O. Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6

        Background The aim of this study was to review the recipient vessels used in our cases of facial reanimation with free functional muscle transfer and to identify patient variables that may predict when the facial vessels are absent. From this we present a protocol for vessel selection in cases when the facial artery and/or vein are absent. Methods Patients were identified from November 2006 to October 2013. Data was collected on patient demographics, facial palsy aetiology, history of previous facial surgery/trauma and flap/recipient vessels used. A standard operative approach was adopted and performed by a single surgeon. Results Eighty-seven eligible patients were identified for inclusion amongst which 98 hemifaces were operated upon. The facial artery and vein were the most commonly used recipient vessels (90% and 83% of patients, respectively). Commonly used alternative vessels were the transverse facial vein and superficial temporal artery. Those with congenital facial palsy were significantly more likely to lack a suitable facial vein (P=0.03) and those with a history of previous facial surgery or trauma were significantly more likely to have an absent facial artery and vein (P<0.05). Conclusions Our algorithm can help to guide vessel selection cases of facial reanimation with free functional muscle transfer. Amongst patients with congenital facial palsy or in those with a previous history of facial surgery or trauma, the facial vessels are more likely to be absent and so the surgeon should then look towards the transverse facial vein and superficial temporal artery as alternative recipient structures.

      • SCOPUSKCI등재

        Scar Revision Surgery: The Patient's Perspective

        Miranda, Benjamin H,Allan, Anna Y,Butler, Daniel P,Cussons, Paul D Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.6

        Background Insufficient satisfaction outcome literature exists to assist consultations for scar revision surgery; such outcomes should reflect the patient's perspective. The aim of this study was to prospectively investigate scar revision patient satisfaction outcomes, according to specified patient-selection criteria. Methods Patients (250) were randomly selected for telephone contacting regarding scar revisions undertaken between 2007-2011. Visual analogue scores were obtained for scars pre- and post-revision surgery. Surgery selection criteria were; 'presence' of sufficient time for scar maturation prior to revision, technical issues during or wound complications from the initial procedure that contributed to poor scarring, and 'absence' of site-specific or patient factors that negatively influence outcomes. Patient demographics, scar pathogenesis (elective vs. trauma), underlying issue (functional/symptomatic vs. cosmetic) and revision surgery details were also collected with the added use of a real-time, hospital database. Results Telephone contacting was achieved for 211 patients (214 scar revisions). Satisfaction outcomes were '2% worse, 16% no change, and 82% better'; a distribution maintained between body sites and despite whether surgery was functional/symptomatic vs. cosmetic. Better outcomes were reported by patients who sustained traumatic scars vs. those who sustained scars by elective procedures (91.80% vs. 77.78%, P=0.016) and by females vs. males (85.52% vs. 75.36%, P<0.05), particularly in the elective group where males (36.17%) were more likely to report no change or worse outcomes versus females (16.04%) (P<0.01). Conclusions Successful scar revision outcomes may be achieved using careful patient selection. This study provides useful information for referring general practitioners, and patient-surgeon consultations, when planning scar revision.

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