Research on Constitutive Models and Hot Workability of As-Homogenized Al- Zn-Mg-Cu Alloy During Isothermal Compression

Dan Xiao,Xiaoyan Peng,Xiaopeng Liang,Ying Deng,Guofu Xu,Zhimin Yin 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.3

Hot compression tests of as-homogenized Al-Zn-Mg-Cu alloy were performed at the deformation temperaturerange of 350-450 °C and the strain rate range of 0.001-1 s-1. The Arrhenius-type constitutive equation and theAvrami-type model were established to predict the flow behaviors of the alloy respectively. The processing map atthe true strain of 0.92 was developed to evaluate the workability of the alloy and the related microstructures wereinvestigated. The results show that the Avrami-type model has a higher accuracy to predict flow stress than theArrhenius-type constitutive equation. The stable deformation occurs under high temperature or low strain ratemainly owing to the dynamic recrystallization. Flow instability is prone to occur under the condition of low temperatureand high strain rate due to the initiation and the propagation of micro-cracks. According to the processingmap and corresponding microstructure characteristics, the optimum processing parameters are in the temperaturerange of 380-405 °C and the strain rate range of 0.006-0.035 s-1.

Mortality of Major Cancers in Guangxi, China: Sex, Age and Geographical Differences from 1971 and 2005

Deng, Wei,Long, Long,Li, Ji-Lin,Zheng, Dan,Yu, Jia-Hua,Zhang, Chun-Yan,Li, Ke-Zhi,Liu, Hai-Zhou,Huang, Tian-Ren Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

The incidence and mortality rates of liver and nasopharyngeal cancer in Guangxi province of China have always been among the highest in the world, and cancer is one of the major diseases that pose a threat to the health of residents in Guangxi. However, no systematic study has been performed to evaluate the time trends in the structure of cancer-related deaths and cancer mortality. In this study, we reveal sex, age and geography differences of cancers mortality between three death surveys (1971 to 1973, 1990 to 1992, and 2004 to 2005). The results show that the standardized mortality rate of cancer in Guangxi residents has risen from 43.3/100,000 to 84.2/100,000, the share of cancer deaths in all-cause deaths has increased from 13.3% to 20.7%, and cancer has become the second most common cause of death. The five major cancers, liver cancer, lung cancer, gastric cancer, nasopharyngeal cancer and colorectal cancer, account for 60% of all the cancer deaths. Cancers with growing mortality rates over the past 30 years include lung cancer, colorectal cancer, liver cancer and female breast cancer, of which lung cancer is associated with the sharpest rise in mortality, with a more than 600% rise in both men and women. Cancer death in Guangxi residents occurs mainly in the elderly population above 45 years of age, especially in people over the age of 65. The areas with the highest mortality rates for liver cancer and nasopharyngeal cancer, which feature regional high incidences, include Chongzuo and Wuzhou. Therefore, for major cancers such as liver cancer, lung cancer, gastric cancer, nasopharyngeal cancer and female breast cancer in Guangxi, we can select high-risk age groups as the target population for cancer prevention and control efforts in high-prevalence areas in a bid to achieve the ultimate goal of lowering cancer mortality in Guangxi.

UNICITY OF MERMORPHIC FUNCTIONS CONCERNING SHARED FUNCTIONS WITH THEIR DIFFERENCE

Deng, Bingmao,Fang, Mingliang,Liu, Dan Korean Mathematical Society 2019 대한수학회보 Vol.56 No.6

In this paper, we investigate the uniqueness of meromorphic functions of finite order concerning sharing small functions and prove that if f(z) and ${\Delta}_cf(z)$ share a(z), b(z), ${\infty}$ CM, where a(z), b(z)(${\neq}{\infty}$) are two distinct small functions of f(z), then $f(z){\equiv}{\Delta}_cf(z)$. The result improves the results due to Li et al. ([9]), Cui et al. ([1]) and $L{\ddot{u}}$ et al. ([12]).

Unicity of mermorphic functions concerning shared functions with their difference

Bingmao Deng,Mingliang Fang,Dan Liu 대한수학회 2019 대한수학회보 Vol.56 No.6

In this paper, we investigate the uniqueness of meromorphic functions of finite order concerning sharing small functions and prove that if $f(z)$ and $\Delta_c f(z)$ share $a(z), b(z), \infty$ CM, where $a(z), b(z) (\not \equiv \infty)$ are two distinct small functions of $f(z)$, then $f(z)\equiv \Delta_cf(z)$. The result improves the results due to Li et al.~(\cite{LXM}), Cui et al.~(\cite{CN}) and L\"{u} et al.~(\cite{LF}).

A Novel GSMC-based ACV Trajectory Tracking Under Unknown Disturbance Upper Bound and Time-varying Model Coefficients

Mingyu Fu,Dan Bai,Hanbo Deng,Lijing Dong 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4

In this paper, a novel global sliding mode controller (GSMC) with a comprehensive observer is used to solve the problems of time-varying coefficients, modeling errors and disturbance with unknown upper bound in the trajectory tracking control of the air-cushion vehicle (ACV). Considering the multiple resistance coefficients that change with the motion state in the ACV’s dynamic model, a comprehensive observer is used to estimate and compensate for the model uncertainty in real time. An adaptive disturbance estimation law without disturbance upper bound is given to compensate for the total disturbance. On the basis of real-time compensation of model uncertainty by adaptive estimation law, a new GSMC with hyperbolic tangent function is proposed to track the ACV’s trajectory. The interconnected system of observer and trajectory tracking controller is shown to have enhanced robustness. Finally, simulations verify the effectiveness of the proposed control approaches.

Hsa-miRNA-143-3p Reverses Multidrug Resistance of Triple-Negative Breast Cancer by Inhibiting the Expression of Its Target Protein Cytokine-Induced Apoptosis Inhibitor 1 In Vivo

Yu Wei Deng,Wen Jing Hao,Yi Wen Li,Yi Xin Li,Bo Chen Zhao,Dan Lu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.3

Purpose: Multidrug resistance (MDR) remains a major obstacle in the treatment of triple-negative breast cancer (TNBC) with conventional chemotherapeutic agents. A previous study demonstrated that hsa-miRNA-143-3p plays a vital role in drug resistance of TNBC. Downregulation of hsa-miRNA-143-3p upregulated the expression of its target protein cytokine-induced apoptosis inhibitor 1 (CIAPIN1) in order to activate MDR, while upregulation of hsa-miRNA-143-3p effectively enhances the sensitivity of drug-resistant TNBC cells to chemotherapeutics. The present study aimed to further verify these findings in vivo. Methods: We established a hypodermic tumor nude mice model using paclitaxel- resistant TNBC cells. We expressed ectopic hsa-miRNA- 143-3p under the control of a breast cancer-specific human mammaglobin promoter that guided the efficient expression of exogenous hsa-miRNA-143-3p only in breast cancer cells. Thereafter, we overexpressed hsa-miRNA-143-3p in xenografts using a recombinant virus system and quantified the expression of hsa-miRNA-143-3p, CIAPIN1 protein, and proteins encoded by related functional genes by western blot. Results: We successfully completed the prospective exploration of the intravenous virus injection pattern from extensive expression to targeted expression. The overexpression of hsa-miRNA-143-3p significantly alleviated chemoresistance of TNBC by inhibiting viability. In addition, we observed that the expression of CIAPIN1 as a hsa-miRNA-143-3p target protein was remarkably decreased. Conclusion: We partly illustrated the mechanism underlying the hsa-miRNA-143-3p/CIAPIN1 drug resistance pathway. HsamiRNA- 143-3p as a tumor suppressive microRNA may be a novel target to effectively reverse MDR of TNBC in vivo.

The Effects of ASMase Mediated Endothelial Cell Apoptosis in Multiple Hypofractionated Irradiations in CT26 Tumor Bearing Mice

Zhu, Hong,Deng, Kai,Zhao, Ya-Qin,Wang, Xin,Shen, Ya-Li,Liu, Tai-Guo,Cui, Dan-Dan,Xu, Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.11

Background: To investigate the effects of ASMase mediated endothelial cell apoptosis in multiple hypofractionated irradiations in CT26 tumor bearing mice. Materials and Methods: Thirty-five CT26 tumor bearing mice were subjected to single ionizing radiation (IR) of 0, 3, 6, 9, 12, 15, 18 Gy. Eight hours after IR, the mice were sacrificed and tumor tissues were used for CD31 immunohistochemistry staining, TUNEL and CD31 double staining, ASMase activity assay. Then 6 and 12 Gy were chosen for multiple hypofractionated IR experiments according to the above results. Each time after IR, 5 mice were sacrificed and assayed as above. Results: The ASMase activities were increased significantly after a single IR of 12 Gy or higher which was accompanied with remarkable increased endothelial cell apoptosis and decreased MVD. For 6 Gy which was not high enough to trigger ASMase activation, after 2 or more times of IR, the ASMase activities were significantly increased accompanied with remarkable increased endothelial cell apoptosis and decreased MVD. While for 12 Gy, after 2 or more times of IR, the ASMase activities and endothelial cell apoptosis rates were maintained without remarkable increase; however, the MVD was significantly decreased. What's more, the cancer cell apoptosis rates were significantly increased after multiple IR for both 6 Gy and 12 Gy. Conclusions: ASMase mediated endothelial cell apoptosis may play an important role in the process of multiple hypofractionated IR for CT26 colorectal carcinoma.

Improved Dyeing of Meta-aramid Based on Particle Flow Dyeing Mechanism Using Hot-pressing Dyeing Method

Xin Chen,Dan Sheng,Honghui Xia,Weilin Xu,Bo Deng,Genyang Cao 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12

In this study, a combined dyeing method by integrating the advantages of both carrier dyeing and hot-pressingdyeing was utilized for the dyeing of meta-aramid. A rapid dyeing with increased mechanical properties of the fibers wasachieved for the meta-aramid fiber. A so-called particle flow mechanism involving both N,N-dimethylacetamide (DMAc)and dye molecules was proposed to explain the accelerating effect of this unique dyeing method. The mechanical propertiesand thermodynamic stability of the fiber after hot-pressing were both increased. XRD results showed increasedcorresponding fiber crystallinity. TEM showed that the disperse dyes were well dispersed in DMAc. Cross-sectional opticalphotographs of dyed fibers revealed that the dyes were successfully carried into the interior of the fiber under the synergiceffect of temperature and pressure. Combined with hot-pressing dyeing, the dyeing cycle for the meta-aramid could begreatly shortened and the amounts of dyes and carriers could be significantly reduced.

An Adaptive Compressed Sensing Algorithm of Optical Fiber Pipeline Pre-warning Data

Hongjie Wan,Haojiang Deng,Xiaoming Xie,Qiaoning Yang,Dan Su 보안공학연구지원센터 2013 International Journal of Future Generation Communi Vol.6 No.4

The function, mechanisms, and clinical applications of metformin: potential drug, unlimited potentials

Jianhong Liu,Ming Zhang,Dan Deng,Xiao Zhu 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.5

Metformin has been used clinically for more than 60 years. As time goes by, more and more miraculous effects of metformin beyond the clinic have been discovered and discussed. In addition to the clinically approved hypoglycemic effect, it also has a positive metabolic regulation effect on the human body that cannot be ignored. Such as anti-cancer, anti-aging, brain repair, cardiovascular protection, gastrointestinal regulation, hair growth and inhibition of thyroid nodules, and other nonclinical effects. Metformin affects almost the entire body in the situation taking it over a long period, and the preventive effects of metformin in addition to treating diabetes are also beginning to be recommended in some guidelines. This review is mainly composed of four parts: the development history of metformin, the progress of clinical efficacy, the nonclinical efficacy of metformin, and the consideration and prospect of its application.