Development of Low Glycemic Index Foods and Their Glucose Response in Young Healthy Non-Diabetic Subjects

Damayanti Korrapati,Shanmugam Murugaiha Jeyakumar,Sangamitra Katragadda,Laxmi Rajkumar Ponday,Vani Acharya,Srinivas Epparapalli,Stephy Joseph,Ayylasomayajula Vajreswari 한국식품영양과학회 2018 Preventive Nutrition and Food Science Vol.23 No.3

Development of low glycemic-foods is important in the prevention and management of type 2 diabetes. In this context, we prepared four test foods (TFs) (two mixed mini-meals and two breakfast items) with low glycemic-components and assessed their glycemic index (GI) in young healthy non-diabetic volunteers with mean age of 29 yr, body mass index of 24 kg/m², and fasting plasma glucose levels less than 4.62 mmol/L. Volunteers were given 50 g of glucose, as a reference food (RF) on the first day, and TFs, i.e. TF1 (mixed mini meal: roti made of wheat flour and chana dal+ curd), TF2 [mixed mini meal made of wheat, pearl barley, and Bengal gram flour (besan) mix with chana whole (unhusked chana+curd)], TF3 (pearl barley rawa upma), and TF4 (wheat rawa upma) were given 2-day intervals in the same order. Glucose levels at fasting conditions and after the consumption of RF and TFs at different time intervals (15, 30, 45, 60, 90, and 120 min) were measured, and the incremental area under curve (IAUC) for glucose and GI of the TFs were calculated. The glucose IAUC values at different time points were highest for TF2 (GI=71.9±7.4), while all other TFs had comparable GI in the range of 53.7∼54.9. Among the various TFs, TF1, TF3, and TF4 exerted low to moderate glycemic response, and thus can be classified as low glycemic-foods. Nevertheless, these foods need to be tested for their efficacy in controlling and/or managing hyperglycemia and glucose over-load in diabetic subjects.

The Movement of Boron Compound by Infusion Method and Combination of Injection and Bandage-Wrapping

( Ratih Damayanti ),( Evi Sribudiani ),( Sonia Somadona ),( Djarwanto ),( Didi Tarmadi ),( Yusup Amin ),( Sulaeman Yusuf ),( Esti Rini Satiti ),( Wa Ode Muliastuty Arsyad ),( Rudianda Sulaeman ),( Sya 한국목재공학회 2020 목재공학 Vol.48 No.4

The existing preservation methods are difficult to be applied to a large dimension log which is needed for making traditional wooden ship ‘Jalur’ in Riau Province. Novel techniques to provide the use of readily available species to replace traditional species alternative were investigated. These included infusion and a combination of injection and bandage-wrapping methods for preserving living trees of Balam (Macaranga conifera (Rchb.f. & Zoll.) Müll.Arg.) and Bintangor (Calophyllum soulattri Burm.f.). Water-based boron compounds were applied as wood preservatives. In total, 18 discs from the bottom, middle, and top of four trees and two controls were used. Trees undergoing treatment were also used to see how wood anatomical structure might affect the boron penetration. The overall aim was to identify the best method for use in Jalur manufacturing. The results showed that in infused Balam tree where the hose position for the preservative intake was deep (10-15 cm from the bark), no boron compound was observed in the outer sapwood. Combination of injection and bandage-wrapping method gave higher percentage of boron penetration at bottom and middle of Balam tree. However, infused Bintangor showed 100% boron penetration. The larger vessel diameter, the absence of tyloses, and the simple perforation plates in Bintangor wood were likely to have contributed to the higher penetration of boron. The combination of bandage-wrapping and infusion, or alternatively by infusing the living trees close to the bark, and at as low as position in the stem gives better protection when treatments are applied to living trees.

Enzyme Replacement Therapy for Lysosomal Storage Disease in Indonesia

Sjarif, Damayanti Rusli,Hafifah, Cut Nurul Association for Research of MPS and Rare Diseases 2018 Journal of mucopolysaccharidosis and rare disease Vol.4 No.1

Rare diseases are life threatening or chronically debilitating diseases with a low prevalence (less than 2,000 people in a population), which includes lysosomal storage diseases. These diseases are often seen as unimportant especially in developing countries, such as Indonesia, due to small number of patients. National Rare Disease Center in Indonesia was pioneered almost 20 years ago and officially established in 2017 by the Indonesian Minister of Health. Lysosomal storage disease become the most commonly found inborn errors of metabolism (IEM) in Indonesia due to easily accessible diagnostic facilities. Currently there are 7 patients receiving ERT in this mixed-donation scheme, one patient with Gaucher disease and 6 patients with MPS type II. Few challenges for ERT in Indonesia include importation through special access scheme, preparation of ERT infusion in intensive care settting, and cost of treatment. Even with limited resources, healthcare professionals in Indonesia have been giving the best care possible for rare disease patients, especially to provide diagnostic facilities through collaboration and treatment options for treatable rare diseases. Improvements in care for rare disease patients are still needed.

Integrated Information System for Early Detection of Maternal Risk Factors Based on Continuum of Care Approach of Mother and Toddler Cohorts

Nyoman Anita Damayanti,Darmawan Setijanto,Arief Hargono,Ratna Dwi Wulandari,Maya Weka Santi,Benny Tjahjono,Aulia Ramadhani 대한의료정보학회 2019 Healthcare Informatics Research Vol.25 No.3

Objectives: The aim of this study is to demonstrate how an integrated information system of mother and toddler cohorts can be developed as a basis of the continuum of care approach that subsequently can be used as the basis of early detection of risk factors of maternal mortality. Methods: This research was carried out qualitatively. The data was collected through three techniques: in-depth interviews, focus group discussion, and document studies at six public health centers located in four sub-districts of Surabaya, Indonesia. This research was conducted from 2016 to 2018. Results: The data collected from this research has become a basis input data requirement analysis for an integrated mother and toddler cohort information system. The system accommodates all the variables in each period of pre-marriage, pregnancy, labor, infancy and toddlerhood. The system facilitates healthcare workers to retrieve data and information related to mother and toddler health status. Conclusions: The availability of various pieces of information enables the health status of mothers and toddlers to be monitored thoroughly throughout their long-life cycle. This continuum of care approach is beneficial in the early detection and management of risk factors of maternal mortality, such as pregnancy complications as well as childbirth and postpartum complications.

The Role of Innate and Adaptive Immune Cells in the Immunopathogenesis of Chronic Obstructive Pulmonary Disease

Nurwidya, Fariz,Damayanti, Triya,Yunus, Faisal The Korean Academy of Tuberculosis and Respiratory 2016 Tuberculosis and Respiratory Diseases Vol.79 No.1

Chronic obstructive pulmonary disease (COPD) is a chronic and progressive inflammatory disease of the airways and lungs that results in limitations of continuous airflow and is caused by exposure to noxious gasses and particles. A major cause of morbidity and mortality in adults, COPD is a complex disease pathologically mediated by many inflammatory pathways. Macrophages, neutrophils, dendritic cells, and CD8+ T-lymphocytes are the key inflammatory cells involved in COPD. Recently, the non-coding small RNA, micro-RNA, have also been intensively investigated and evidence suggest that it plays a role in the pathogenesis of COPD. Here, we discuss the accumulated evidence that has since revealed the role of each inflammatory cell and their involvement in the immunopathogenesis of COPD. Mechanisms of steroid resistance in COPD will also be briefly discussed.

Sulphur Free Radical Reactivity of Thioproline and Crude Extracts of Parkia timoriana (DC.) Merr.

Robert Thangjam,Damayanti Devi Maibam 대한환경공학회 2012 Environmental Engineering Research Vol.17 No.-

Parkia timoriana (DC.) Merr. of the family Leguminosae (Fabaceae) and sub-family Mimosoideae, commonly known as tree bean is widely distributed throughout northeast India. It is considered to be a multipurpose tree, with various food and medicinal uses. The seeds are consumed at all developmental stages, and are considered to be a special delicacy due to their distinctive aroma and flavour. The characteristic sulphur aroma of the seeds is associated with the thiol amino acid derivative thioproline, which is a condensation product of formaldehyde and cysteine. In the present study, the presence of formaldehyde and thiol in the different developmental stages of the fruits were evaluated. The level of formaldehyde and thiol content was found to increase with the maturity of the seeds. The generation of sulfhydryl free radicals by thioproline and crude P. timoriana seed extracts on gamma irradiation were observed with the visible destruction of curcumin. The protection of DNA against gamma irradiation in the presence of thioproline in the present study also provides a new lead for investigations into protection against radiotherapy and reduction of risk for exposed individuals.

Improving Capacity of Older Adults with Locomotive Syndrome Stage 1 Living in Nursing Home: A Pilot Clinical Trial

Michael Prayogo,Damayanti Tinduh,Dewi Poerwandari,Rwahita Satyawati Dharmanta,Sri Mardjiati Mei Wulan,Yukio Mikami,Soenarnatalina Melaniani 대한노인병학회 2022 Annals of geriatric medicine and research Vol.26 No.4

Background: Aging causes locomotive syndrome (LS), which is characterized by difficulty in walking. The present study determined the effects of locomotion training and regular aerobic exercise programs on the aerobic capacity of older nursing home residents with LS stage 1. Methods: This randomized controlled trial included 24 participants aged 60-80 years with LS stage 1 residing in a single nursing home in Surabaya, Indonesia. The participants were randomly assigned to either the locomotion training group (LTG) or the control group (CG). Both the groups performed 30 minutes of a daily group-based aerobic exercise program for 8 weeks. The LTG performed additional locomotion training three times weekly, with three sets per session, gradually increasing to five sets per session according to the participant’s tolerance. Two-minute walking test (2MWT) values before and after the 8-week intervention were determined in both the groups and converted to maximum oxygen consumption (VO2max) values. Results: After 8 weeks of intervention, a significant increase in VO2max was observed in both the groups (both p<0.05). The LTG showed a more significant improvement in VO2max (p<0.05) compared to the CG. Conclusion: The study results demonstrated the positive effect of 8 weeks of locomotion training and regular aerobic exercise programs in improving the aerobic capacity of older adult nursing home residents with LS stage 1.

REVIEW : The Role of Innate and Adaptive Immune Cells in the Immunopathogenesis of Chronic Obstructive Pulmonary Disease

( Fariz Nurwidya ),( Triya Damayanti ),( Faisal Yunus ) 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.1

Chronic obstructive pulmonary disease (COPD) is a chronic and progressive inflammatory disease of the airways and lungs that results in limitations of continuous airflow and is caused by exposure to noxious gasses and particles. A major cause of morbidity and mortality in adults, COPD is a complex disease pathologically mediated by many inflammatory pathways. Macrophages, neutrophils, dendritic cells, and CD8+ T-lymphocytes are the key inflammatory cells involved in COPD. Recently, the non-coding small RNA, micro-RNA, have also been intensively investigated and evidence suggest that it plays a role in the pathogenesis of COPD. Here, we discuss the accumulated evidence that has since revealed the role of each inflammatory cell and their involvement in the immunopathogenesis of COPD. Mechanisms of steroid resistance in COPD will also be briefly discussed.

Modification of In Vitro Culture Method of Paphiopedilum glaucophyllum for Callus Induction

Elizabeth Handini,Ratna Uli Damayanti Sianturi,Popi Aprilianti,Yupi Isnaini,Endang Semiarti,Sri Rianawati,Saniyatun Mar’atus Solihah 한국육종학회 2023 Plant Breeding and Biotechnology Vol.11 No.4

The in vitro vegetative propagation technique of the Paphiopedilum glaucophyllum (callus propagation) still haveproblems to date. The aim of this study is to determine the effect of the media and plant growth regulator (PGR) on seed germination andcallus induction with shoot tip as an explant and use the planlet from elongation treatment result. The seed germination uses modifiedKnudson C (KC medium) with the addition of 3 concentrations of NAA (0; 5; 10 mg/L). The second study is the elongation treatmentof the explants uses four modified Murashige and Skoog (MS) medium (1/2 P, ½ P5, MP and MP5). And for the callus induction studyconsisted of two methods, callus induction with direct planting to the treatment medium by using SH medium with addition of2,4-Dichlorophenoxyacetic acid (2,4-D) 1 mg/L and Thidiazuron (TDZ) (0, 0.5, 1, 1.5 dan 2 mg/L). The second method used theexplants resulted from elongation treatment. It used half-strength Wattanawikkit medium with addition of TDZ (0; 0.5; 1; 1.5; 2 mg/L)and 2,4-D (0; 1; 5; 10 mg/L). All callus then subcultured in the half-strength MS (½ MS) medium containing 2,4-D 1 mg/L and TDZ (0;1; 1.5 mg/L). All the experiments used a completely randomized design with 3 repetitions. The results showed that the seeds germinated2 months after planting (MAP) for all media. The optimal media for explants elongation of P. glaucophyllum was MP5 media. Meanwhile, for the first callus induction experiments, explants had more callus in basic SH media with 2.4-D 1 mg/L and TDZ 0.5-1.5mg/L that grew in the dark. The second experiment, the optimal medium for callus induction was half MS with Thidiazuron 1.5 mg/Land 2.4-D 1 mg/L (T1.5D1). The the suitable medium for callus development is ½ MS) medium with 2,4-D 1 mg/L.

Improving Mother’s Mosquito Eradication Behavior through A Text-Messaging Based Intervention : Dengue Chit-Chat in Bali

Ni Luh Putu Nopriani,Made Rini Damayanti S,Meril Valentine Manangkot,Indah Mei Rahajeng ASCONS 2019 IJBSA Vol.1 No.1

Background/Objectives: Mother’s Mosquito Eradication (ME) behavior plays important role on ME in Indonesia. Dengue Chit-Chat (DCC) is a text-messaging based intervention that can be used to improve ME. The aim of this study was to analyse the effect of DCC on the mother’s ME behavior in Bali. Methods/Statistical analysis: This study was a quasi-experimental with pre-test and post-test with control group design and cluster sampling technique. Sixty-seven participants were divided into experimental and control groups. The experimental group was given a three weeks message program that was delivered four times a week. Findings: Statistical analyses showed no significant differences in knowledge (p=0.064) and container index score (p=0.051), but showed significant differences in attitude (p<0.001) and practice (p<0.001) before and after the intervention. Improvements/Applications: Based on these results, we conclude that DCC can be used to increase attitude and practice of ME. However, study with a longer intervention duration may be needed to explore the behavioral effect of text-messaging intervention on ME.