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RISS 인기검색어
- 검색키워드
- 저자 : Dalia H El-Ghoneimy (검색결과 3 건)
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Zeinab A. El-Sayed,Dalia H El-Ghoneimy,Dina El-Shennawy,Manar W. Nasser 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.3
Purpose: To evaluate the frequency of banana sensitization and allergy among a group of atopic Egyptian children in relation to parental/self reports. Methods: This is a case-control study included 2 groups of allergic children with and without history of banana allergy, each included 40patients. They were subjected to skin prick test (SPT) using commercial banana allergen extract and prick-prick test (PPT) using raw banana, in additionto measuring the serum banana-specific IgE. Oral banana challenge was performed in suspected cases. Results: Banana allergy was diagnosedin 3 (7.5%) patients based on positive history of allergy on exposure to banana, positive SPT/PPT and elevated banana-specific IgE. The 3 patientshad bronchial asthma with exacerbation upon banana exposure. The PPT results conform with those of SPT both in diagnosis of banana allergy andin the skin reactivity to banana. Serum banana-specific IgE was detectable in the whole studied sample with higher serum level among those withouthistory of banana allergy (P=0.005). Oral banana challenge was negative for 20 patients with history of banana allergy and positive serum banana-specific IgE but negative SPT and PPT. Conclusions: Self/parental reports of banana allergy is high while the actual banana allergy is uncommon. The PPT seems as reliable as SPT in diagnosis of banana allergy unlike specific IgE which reflects sensitization rather than allergy. Oralfood challenge remains the most helpful tool for diagnosis of food allergy in suspected cases.
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A Rare Association Between Leukocyte Adhesion Deficiency Type I and Psoriasis in Humans
Zeinab Awad El-Sayed,Dalia H El-Ghoneimy,Heba Abd-Allah,Hanaa M Afifi 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.2
The β2 integrins are expressed exclusively on leukocytes and participate in many immune and inflammatory processes. This subfamily comprises four heterodimeric glycoproteins with a common β-subunit, designated β2 (CD18). Spontaneous mutations of the CD18 gene result in leukocyte adhesion deficiency type I (LAD-I). Low level of CD18 expression has also been implicated in the pathogenesis of psoriasis. We here describe a child with recurrent skin infections without pus formation, persistent gingivitis and periodontitis. His blood counts showed persistent leukocytosis (neutrophilia). CD11b expression was defective on neutrophils, while that of CD18 was normal. So, our patient represents a mild variant of LAD-I with possible dysfunctional CD18. Moreover, he developed psoriasis with reduced CD18 expression on CD4+ T-cells. Psoriasiform dermatitis has been described before in association with LAD-I, however, clinically and histologically confirmed psoriasis in association with LAD-I has been described only in CD18 hypomorphic mice. Therefore, our patient represents the first clinically and histopathologically documented association between LAD-I and psoriasis in humans. It lends support to the role of β2 integrins in the etiopathogenesis of psoriasis.
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Clinical Predictors of Primary Immunodeficiency Diseases in Children
Shereen M. Reda,Dalia H El-Ghoneimy,Hanaa M Afifi 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.2
Purpose: To promote awareness of primary immunodeficiency (PID), the “10 warning signs” of PID and an immunodeficiency-related (IDR) scorewere developed. However, their efficiency in identifying PID cases was not sufficiently evaluated in clinical practice. The objective of this study wasto test the validity of the 10 warning signs and IDR score in identifying PID among children with recurrent infections at a tertiary pediatric hospital inEgypt. Methods: A retrospective analysis of the medical records of 204 patients was performed. Of these patients, 92 had defined PID diseasesand 112 were considered non-PID cases because investigations were inconclusive. Results: Demonstrating two warning signs and an IDR scoreof 6 led to sensitivities of 94 and 66%, respectively, and specificities of 64 and 75%, respectively, in identifying PID cases. The strongest predictor ofPID was family history that, if combined with the need for intravenous antibiotics, recurrent deep-seated infections, and failure to thrive, could identify81% of PID patients. A family history of PID, sibling death, and/or parental consanguinity would predict 92% of combined immunodeficiencies,92% of phagocyte defects, 87% of well-identified immunodeficiency syndromes, and 84% of antibody deficiency if the need for intravenous antibioticsis considered in the latter. Conclusions: The 10 warning signs and IDR score do not aid in an early diagnosis of severe PID. Educational campaignsshould target pediatricians aiming to increase PID awareness and to address family history of PID, parental consanguinity, and previous siblingdeath as key predictors of PID in communities with a high prevalence of consanguineous marriages.
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