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Bae, Wonki,Hancock, Dale D.,Call, Douglas R.,Park, Yong Ho,Berge, Anna Catharina B.,Finger, Regina M.,Sischo, William M.,Besser, Thomas E. Elsevier 2007 Veterinary microbiology Vol.122 No.3-4
<P><B>Abstract</B></P><P>The purpose of this study was to investigate the genetic similarity of <I>Campylobacter jejuni</I> and <I>Campylobacter coli</I> with similar antimicrobial resistance phenotypes, isolated from cattle on different farms and at different times, in order to evaluate the possible existence of disseminated antimicrobial resistant clones. PFGE after <I>Sma</I>I and <I>Kpn</I>I restriction identified 23 and 16 distinct PFGE patterns among 29 <I>C. jejuni</I> and 66 <I>C. coli</I> isolates, respectively. In <I>C. coli</I>, 51 (77%) of the resistant isolates demonstrated one of the four indistinguishable PFGE patterns, whereas only 24% doxycycline resistant <I>C. jejuni</I> shared one of the two indistinguishable PFGE patterns. The genetic mechanisms of resistance were homogeneous within and between these clonal types. Genetically indistinguishable (clonal) groups of <I>C. coli</I> accounted for most <I>Campylobacter</I> sp. with multiple antimicrobial resistance observed in this study, consistent with a role for clonal dissemination in the epidemiology of resistance in this species.</P>
박영경,Lawrence K. Fox,Dale D. Hancock,Wade McMahan,Yong Ho Park 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.1
Changes in udder health and antibiotic resistance of mastitis pathogens isolated from dairies upon conversion from conventional to organic management over a 3-year period was studied. Coagulase-negative staphylococci (CNS) were the most prevalent mastitis pathogens isolated. CNS were significantly less resistant to b-lactam antibiotics when isolated from milk after the herd transitioned to organic management. Cessation of the use of antimicrobial therapies in dairies in combination with organic management could lead to a reduction in the antimicrobial resistance of mastitis pathogens.
Insulin Resistance Does Not Influence Gene Expression in Skeletal Muscle
Nguyen, Lisa L.,Kriketos, Adamandia D.,Hancock, Dale P.,Caterson, Ian D.,Denyer, Gareth S. Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.4
Insulin resistance is commonly observed in patients prior to the development of type 2 diabetes and may predict the onset of the disease. We tested the hypothesis that impairment in insulin stimulated glucose-disposal in insulin resistant patients would be reflected in the gene expression profile of skeletal muscle. We performed gene expression profiling on skeletal muscle of insulin resistant and insulin sensitive subjects using microarrays. Microarray analysis of 19,000 genes in skeletal muscle did not display a significant difference between insulin resistant and insulin sensitive muscle. This was confirmed with real-time PCR. Our results suggest that insulin resistance is not reflected by changes in the gene expression profile in skeletal muscle.