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Sohn, Dae Kyung,Han, Kyung Su,Hong, Chang Won,Chang, Hee Jin,Jeong, Seung-Yong,Park, Jae-Gahb Mary Ann Liebert 2008 Journal of Laparoendoscopic & Advanced Surgical Te Vol.18 No.6
<P>BACKGROUND: Small rectal carcinoid tumors (<or=1 cm in diameter) can be treated by endoscopic resection, but complete resection may be difficult if tumors are located in the deep submucosal layer. This study was performed to identify the clinicopathologic factors affecting the complete resection of small rectal carcinoid tumors, using the endoscopic submucosal resection with cap aspiration technique (ESMR-C). MATERIALS AND METHODS: Forty-one consecutive patients with 42 rectal carcinoid tumors who underwent ESMR-C from October 2003 to November 2006 were assessed. Complete resection was defined as a clean margin that was free of tumor invasion at the lateral and inferior edges. RESULTS: The rate of complete tumor removal by ESMR-C was 85.7% and no complications occurred. The tumor size, location, and method of resection did not significantly affect the completeness of resection. Univariate analysis showed that the rate of complete resection was significantly higher when using 19.2-mm, compared with 13.9-mm, caps (96.0 vs. 70.6%; P = 0.032). Multivariate analysis showed that the cap size was an independent factor predicting the completeness of resection. CONCLUSION: The use of large-sized caps increases the completeness of the resection of rectal carcinoid tumors when using ESMR-C.</P>
Original Article : A study of the awareness of chronic Liver diseases among Korean adults
( Dae Won Jun ),( Yong Kyun Cho ),( Joo Hyun Sohn ),( Chang Hyeong Lee ),( Seok Hyun Kim ),( Jong Ryul Eun ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2
Background/Aims: Chronic liver disease is closely associated with lifestyle, and public enlightenment of the lifestyle factors is important in reducing prevalence of chronic liver disease. The KASL (Korean Association for the Study of the Liver) conducted a survey of basic information and epidemiological data regarding chronic liver diseases. Methods: A survey of chronic liver disease involving a total of 2,794 respondents was conducted. The respondents included patients and their guardians, visitors for health check-ups, and online pollees who completed a questionnaire on the awareness of fatty liver or chronic liver disease. Results: Of the entire cohort, 854 (39.7%) said they have had or still have fatty liver or an elevated transaminase level (>40 IU/L), but only 23.4% of the respondents had visited a hospital. It was found that 35% of healthy subjects and 45% of patients and their guardians misunderstood hepatitis B as the hereditary disesase. Furthermore, 26% of the subjects responded that patients with inactive hepatitis B do not require regular follow-up. While 17.9% answered that it is not too late to test for liver cancer when symptoms arise, 38.8% believed that liver transplant in liver cancer patients has a low success rate and is thus not recommended. Conclusions: Despite the inundation of information and widespread media advertising, the awareness of chronic liver disease is unsatisfactory among Korean adults. Systematic nationwide studies are needed to obtain data and information regarding the prevalence of chronic liver disease and patterns of use of the health-care system.
Effects of Korean Ginseng and Wild Simulated Cultivation Ginseng for Muscle Strength and Endurance
Sohn, Eun-Hwa,Yang, Yoon Jung,Koo, Hyun Jung,Park, Dae Won,Kim, Ye-Jin,Jang, Ki Ho,NamKoong, Seung,Kang, Se Chan The Plant Resources Society of Korea 2012 한국자원식물학회지 Vol.25 No.6
Muscle strength and endurance activities of Korean ginseng (Panax ginseng C. A. Meyer; KG) were compared with those of wild simulated cultivation ginseng (WCG) in mice. Fifty male ICR mice were divided into five groups: A (vehicle); B (WCG 100 mg/kg); C (WCG 500 mg/kg); D (KG 100 mg/kg); E (KG 500 mg/kg). Subsequently, the mice were subjected to the forced swimming test (FST) and treadmill test at the $4^{th}$ and $7^{th}$ weeks. The glycogen content in the muscle and blood analysis (levels of glucose, triglyceride (TG), IGF-1) were also performed immediately after the last FST and treadmill test at the $7^{th}$ week. Immobility times in FST were shorter in WCG- than KG-treated groups, and the results of the treadmill tests were also significant except for KG-treated at 100 mg/kg. The glycogen content was increased in both groups with a peak at 500 mg/kg of WCG groups. Serum concentrations of TG and glucose were decreased by administration of KG and WCG and all treated groups showed increase in the level of IGF-1 in serum. These results suggest that KG and WCG supplementations are effective in escalating the muscle strength and endurance.
The First Transcolonic Cholecystectomy in Korea
Dae Kyung Sohn,Seung-Yong Jeong,Yong Beom Cho,Ji Won Park,Woo Yong Lee,Gyu-Seog Choi,Ho-Kyung Chun 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.1
Natural orifice translumenal endoscopic surgery (NOTES) is a new and rapidly evolving hybrid procedure in which the endoscope is introduced into the peritoneal cavity through the stomach, colon, vagina or urethra. A transcolonic approach is applicable for upper abdomen surgery. The present report describes a successful transcolonic cholecystectomy performed in a pig. The total operation time was 180 minutes. The pig survived without any complications for 7 days post-operatively. Necropsy after euthanasia showed no evidence of organ injury, bleeding or suppurative peritonitis, and it revealed that the colonic wall that had been incised and then closed using multiple endoscopic clippings was water-tight and air-tight. This is the first transcolonic cholecystectomy performed in Korea. This approach may represent a promising new method for performing NOTES.
Debonding monitoring of CFRP strengthened RC beams using active sensing and infrared imaging
Sohn, Hoon,Kim, Seung Dae,In, Chi Won,Cronin, Kelly E.,Harries, Kent Techno-Press 2008 Smart Structures and Systems, An International Jou Vol.4 No.4
This study attempts to develop a real-time debonding monitoring system for carbon fiber-reinforced polymer (CFRP) strengthened structures by continuously inspecting the bonding condition between the CFRP layer and the host structure. The uniqueness of this study is in developing a new concept and theoretical framework of nondestructive testing (NDT), in which debonding is detected without relying on previously-obtained baseline data. The proposed reference-free damage diagnosis is achieved based on the concept of time reversal acoustics (TRA). In TRA, an input signal at an excitation point can be reconstructed if the response signal measured at another point is reemitted to the original excitation point after being reversed in the time domain. Examining the deviation of the reconstructed signal from the known initial input signal allows instantaneous identification of damage without requiring a baseline signal representing the undamaged state for comparison. The concept of TRA has been extended to guided wave propagations within the CFRP-strengthened reinforced concrete (RC) beams to improve the detectibility of local debonding. Monotonic and fatigue load tests of large-scale CFRP-strengthened RC beams are conducted to demonstrate the potential of the proposed reference-free debonding monitoring system. Comparisons with an electro-mechanical impedance method and an inferred imaging technique are provided as well.
Sohn, Dae-Won,Kim, Hyung-Kwan,Kim, Myung-A,Song, Yeong-Wook,Noh, Chung-Il,Kim, Duk-Kyung,Kang, I-Seok,Kim, Hojoong,Lee, Sang-Do,Kim, Young-Hwue,Youn, Ho-Joong,Chung, Namsik,Choi, Jae-Young,Jun, Jae-Bu Korean Society of Circulation 2009 Korean Circulation Journal Vol.39 No.3
<P>The purpose of this study was to investigate 1) the beneficial effect of bosentan treatment (125 mg twice daily) on exercise capacity and echocardiographic variables and 2) the profiles and frequency of adverse events in Korean patients with World Health Organization (WHO) class III or IV pulmonary artery hypertension (PAH).</P>
( Won Sohn ),( Dae Won Jun ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Tae Yeob Kim ),( Joo Hyun Sohn ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Recently, gut microbiota has been received attention in pathogenesis of non-alcoholic fatty liver disease (NAFLD). The protective effects of Lactobacillus paracasei on NAFLD and possible mechanism were investigated. Methods: Forty male C57BL/6 mice were randomized into 4 groups for 12 weeks: control, NASH model (high fat+10% fructose diet), Lactobacillus paracasei and Lactobacillus plantarum groups. Hepatic fat deposition, inflammation, serum ALT, AST, and bilirubin were tested. Kupffer cell polarization was evaluated by flow cytometry using M1 and M2 marker. Intestinal permeability was measured by urinary Cr-EDTA amount. Results: Mean body weight of L. paracasei and L. plantarum group were lower than NASH model (38 g vs. 43g, p<0.05). Compared with NASH model mice, serum ALT and AST were significantly decreased in both L. paracasei group and L. plantarum group (ALT: 135.5 U/L vs. 92.9 and 53.7U/L, p<0.05). Intestinal permeability was decreased in both L. paracasei and L. planatrum group compared to NASH model (p<0.05).While hepatic fat deposition and lobular inflammation was significantly decreased in both L. paracasei and L. plantarum groups. Kupffer cell infiltration was significantly low in only L. paracasei group (p<0.05). M2 macrophage population increased in L. paracasei compared to NASH group (62.1% vs 50.2%, p<0.05). But Kupffer cell polarization of L. plantarum group did not showed differences compare to NASH group. Conclusions: Probiotics attenuate hepatic fat deposition and decrease ALT and AST levels in NASH model. L. paracasei, but not L. plantarum prevented steatohepatitis via modulation of Kupffer cell polarization.
Dae Kyung Sohn,Il Won Shin,Jeonghwa Yeon,Jin Yoo,Byung Chang Kim,Bun Kim,Chang Won Hong,Kyung Su Han 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.97 No.6
Purpose: This study aimed to validate an automated calculating system developed for determining the adenoma detection rate (ADR). Methods: To calculate the automated ADR, the data linking processes were as follows: (1) matching the selected colonoscopy results with the pathological results, (2) matching the polyp number from colonoscopy with that from pathology and confirming the histopathological results of each colonic polyp, and (3) confirming the histopathological results, especially the adenoma status of each colonic polyp. To verify the accuracy of the automated ADR calculating system, we manually calculated the ADR for 3 months through medical record review. Accuracy was calculated by measuring the error rate for each value. The cause of error was analyzed by additional order and chart review. Results: After excluding 318 cases, 2,543 patients (1,351 men and 1,192 women; median age, 57.9 years) who underwent colonoscopy were included in this study. When the automated calculating system was used, polyps were found in 1,336 cases (52.6%) and adenomas were found in 1,003 cases (39.4%). When the manual calculating system was used, polyps were found in 1,327 cases (52.2%) and adenomas were found in 1,003 cases (39.4%). The accuracies of the polyp detection rate and ADR according to the automated calculating system were 99.3% and 100%, respectively. Conclusion: We developed a system to automatically calculate the ADR by extracting hospital electronic medical record results and verified that it provided satisfactory results. It may help to improve colonoscopy quality.