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RISS 인기검색어
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- 저자 : Dabo Liu (검색결과 2 건)
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Effects of vortex generators on the wind load of a flat roof: A computational study
Yagebai Zhao,Xiaolong Deng,Hongfu Zhang,Dabo Xin,Zhiwen Liu 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.32 No.1
Vortex generators are commonly used in mechanical engineering and the aerospace industry to suppress flow separation owing to their advantages of simple structure, economic viability, and high level of efficiency. Owing to the flow separation of the incoming wind on the leading edge, a suction area is formed on the roof surface, which results in a lifting effect on the roof. In this research, vortex generators were installed on the windward surface of a flat roof and used to disturb to roof flow field and reduced suction based on flow control theory. Computational fluid dynamics (CFD) simulations were performed in this study to investigate the effects of vortex generators on reduce suction. It was determined that when the vortex generator was installed on the top of the roof on the windward surface, it had a significant control effect on reduce suction on the roof leading edge. In addition, the influence of parameters such as size, placement interval, and placement position of the vortex generator on the control effect of the roof’s suction is also discussed.
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Xi Luo,Haiyu Hong,Jun Tang,Xingmei Wu,Zhibin Lin,Renqiang Ma,Yunping Fan,Geng Xu,Dabo Liu,Huabin Li 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.2
Purpose: MicroRNAs (miRs) were recently recognized to be important for immune cell differentiation and immune regulation. However, whether miRs were involved in allergen-specific immunotherapy (SIT) remains largely unknown. This study sought to examine changes in miR-146a and T regulatory cells in children with persistent allergic rhinitis (AR) after 3 months of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Methods: Twenty-four HDM-sensitized children with persistent AR were enrolled and treated with SCIT (n=13) or SLIT (n=11) for 3 months. Relative miR-146a and Foxp3 mRNA expression, the TRAF6 protein level, and the ratio of post-treatment to baseline IL-10+CD4+ T cells between the SCIT and SLIT groups were examined in the peripheral blood mononuclear cells (PBMCs) of AR patients using quantitative reverse transcription polymerase chain reaction (qRT-PCR), flow cytometry, and Western blot analysis, respectively. Serum levels of IL-5 and IL-10 were determined using ELISA. Results: After 3 months of SIT, both the TNSS and INSS scores were significantly decreased compared to the baseline value (P<0.01). The relative expression of miR-146a and Foxp3 mRNA was significantly increased after both SCIT and SLIT (P<0.01). The ratio of post-treatment to baseline IL-10+CD4+ T cells and the serum IL-10 level were significantly increased in both the SCIT and SLIT groups (P<0.01), whereas the TRAF6 protein level and serum IL-5 level were significantly decreased (P<0.01). No significant differences in these biomarkers were observed between the SCIT and SLIT groups. Conclusions: Our findings suggest that miR-146a and its related biomarkers may be comparably modulated after both SCIT and SLIT, highlighting miR-146a as a potential therapeutic target for the improved management of AR.
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