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Bufalin Induces Mitochondrial Pathway-Mediated Apoptosis in Lung Adenocarcinoma Cells
Ding, Da-Wei,Zhang, Yong-Hong,Huang, Xin-En,An, Qing,Zhang, Xun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: To evaluate the effects of bufalin in A549 human lung adenocarcinoma epithelial cells in vitro and assess the underlying mechanisms. Materials and Methods: Human A549 non-small cell lung cancer (NSCLC) cells were treated with various concentrations of bufalin. Cell proliferation was measured by CCK-8 assay, apoptotic cell percentage was calculated by flow cytometry and morphological change was observed by inverted phase contrast microscopy/transmission electron microscopy. In addition, the membrane potential of mitochondria was detected by JC-1 fluorescence microscopy assay, and the related protein expression of cytochrome C and caspase-3 was analyzed by Western blotting. Results: Bufalin could inhibit the proliferation of A549 cells via induction of apoptosis, with the evidence of characteristic morphological changes in the nucleus and mitochondria. Furthermore, bufalin decreased the mitochondrial membrane potential with up-regulation of cytochrome C in the cytosol, and activation of caspase-3. Conclusions: Bufalin inhibits the proliferation of A549 cells and triggers mitochondria-dependent apoptosis, pointing to therapeutic application for NSCLC.
Energy-saving optimization on active disturbance rejection decoupling multivariable control
Ding Da-Min,Yang Hai-Ma,Liu Jin,Zhang Da-Wei,Jiang Xiao-Hui 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3
An industrial control process multiple-input multiple-output (MIMO) coupled system is analyzed in this study as an example of a Loss of Coolant Accident (LOCA) simulation system. Ordinary control algorithms can complete the steady state of the control system and even reduce the response time to some extent, but the entire system still consumes a large amount of energy after reaching the steady state. So a multivariable decoupled energy-saving control method is proposed, and a novel energy-saving function (economic function, Eco-Function) is specially designed based on the active disturbance rejection control algorithm. Simulations and LOCA simulation system tests show that the Eco-function algorithm can cope with the uncertainty of the multivariable system's internal parameters and external disturbances, and it can save up to 67% of energy consumption in maintaining the parameter steady state.
Integrated Fault Detection and Control for Two-dimensional Roesser Systems
Yingying Ren,Da-Wei Ding 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.2
This paper addresses the problem of integrated fault detection and control for two-dimensional (2-D)Roesser systems. A fault detection observer/controller is designed to detect faults in low-frequency domain andsatisfy some control specifications simultaneously. By the generalized Kalman-Yakubovich-Popov (KYP) lemmaand some useful lemmas, this design problem is formulated as a multiobjective optimization problem. A two-stepalgorithm is proposed to solve this non-convex problem. The effectiveness of the proposed algorithm is illustratedby a numerical example.
Jie Zhang,Da-Wei Ding,Qing Li,Cuijuan An 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.3
This paper investigates the event-triggered control problem of heterogeneous discrete-time multi-agent systems (MASs) subject to uncertainties and noises. Based upon the output regulation theory, a new distributed event-triggered control scheme is proposed to reduce communication burden and attenuate effects of stochastic noises. Two types of event-triggered control laws based on dynamic state feedback and dynamic output feedback are designed, respectively. Moreover, to compensate parameter uncertainties, a p-copy internal model is synthesized into the designed controllers. It is shown that all tracking errors are exponentially ultimately bounded in the mean square sense regardless of uncertainties and noises. Several examples are finally given to demonstrate the validity of main results.
Jie Zhang,Da-Wei Ding,Xinmiao Sun,Xiangpeng Xie 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.5
In this paper, the fault-tolerant bipartite output regulation problem of linear multi-agent systems with two antagonistic subgroups and loss-of-effectiveness actuator faults has been solved by utilizing the output regulation theory. The aim of our study is to design a fault-tolerant controller such that bipartite tracking for the output of exosystem (also seen as the leader) in the presence of actuator faults can be achieved under a directed signed graph, where both collaboration and competition coexist in a multi-agent environment. Firstly, a simultaneous state and fault estimator is designed based upon local output estimation errors such that loss of actuator effectiveness of all followers can be accurately compensated. Then, a distributed adaptive exosystem observer is provided to obtain the information of exosystem since not all followers can directly access exosystem. By using the estimations of state, fault and exosystem, a new cooperative fault-tolerant bipartite output regulation framework with competitive interactions is eventually presented. Finally, we provide a numerical example to demonstrate the effectiveness of the designed fault-tolerant control law.
Zhaoyang Cuan,Da-Wei Ding,Heng Wang,Yahui Liu,Yulong Liu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4
This paper develops a novel control method for solving the challenging problem of simultaneous collision avoidance and target tracking for an unmanned ground vehicle with velocity and heading rate constraints. The problem is formulated as an optimization problem where the trajectory tracking is treated as a soft constraint via control Lyapunov functions and obstacles avoidance is treated as hard constraint via control barrier functions. Two constraints are naturally unified in the context of quadratic programs which ensure that the hard constraint, soft constraint, velocity and heading rate constraints are satisfied simultaneously. Under the proposed strategy, an unmanned ground vehicle can avoid the stationary and moving obstacles while tracking the desired trajectory precisely and smoothly. Finally, three representative simulations are provided to demonstrate the effectiveness of the proposed method.
Distributed Security Control for Complex Cyber-physical Systems Against Denial-of-service Attacks
Xiaojie Huang,Da-Wei Ding,Zhiqiang Li,Cuijuan An 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.2
This paper investigates the problem of distributed security control for complex cyber-physical systems against denial-of-service (DoS) attacks. A distributed security controller with interconnected control nodes is proposed on the basis of piecewise Lyapunov functions. The bounds of attack frequency and attack duration are explicitly calculated to achieve security synchronization. Meanwhile, an event-based data update strategy is proposed to resist the negative influence of DoS attacks on data transmission. Finally, a simulation example is given to verify the effectiveness of the proposed method.
Li, Lei,Chen, Bao-Ding,Zhu, Hai-Feng,Wu, Shu,Wei, Da,Zhang, Jian-Quan,Yu, Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: The aim of this meta-analysis was to compare sensitivities and specificities of fine needle aspiration (FNA) and core needle biopsy (CNB) in the diagnosis of thyroid cancer. Materials and Methods: Articles were screened in Medline, the Cochrane Library, EMBASE and Google Scholar, and subsequently included and excluded based on the patient/problem-intervention-comparison-outcome (PICO) principle. Primary outcome was defined in terms of diagnostic values (sensitivity and specificity) of FNA and CNB for thyroid cancer. Secondary outcome was defined as the accuracy of diagnosis. Compiled FNA and CNB results from the final studies selected as appropriate for meta-analysis were compared with cases for which final pathology diagnoses were available. Statistical analyses were performed for FNA and CNB for all of the selected studies together, and for individual studies using the leave-one-out approach. Results: Article selection and screening yielded five studies for meta-analysis, two of which were prospective and the other three retrospective, for a total of 1,264 patients. Pooled diagnostic sensitivities of FNA and CNB methods were 0.68 and 0.83, respectively, with specificities of 0.93 and 0.94. The areas under the summary ROC curves were 0.905 (${\pm}0.030$) for FNA and 0.745 (${\pm}0.095$) for CNB, with no significant difference between the two. No one study had greater influence than any other on the pooled estimates for diagnostic sensitivity and specificity. Conclusions: FNA and CNB do not differ significantly in sensitivity and specificity for diagnosis of thyroid cancer.
Yingying Ren,Qing Li,Da-Wei Ding,Wen Kang,Yunxia Xia 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.11
This paper investigates the robust controller design for polytopic-type uncertain linear systems disturbed by external disturbances in restricted frequency ranges. The primary goal is to design a state-feedback controller, ensuring that the closed-loop system is robustly stable and keeps a prescribed finite-frequency (FF) disturbanceattenuation performance. For this purpose, a robust generalized Kalman-Yakubovich-Popov (KYP) lemma is applied to describe the finite-frequency specification, aiming at improving the disturbance-attenuation performance over the given frequency range. In this setting, more relaxed analysis conditions for robust stability and finitefrequency specifications are derived by introducing additional slack variables, which contain some existing conditions as special cases. Based on the homogeneous polynomially parameter-dependent (HPPD) technique, new controller design conditions in terms of linear matrix inequalities (LMIs) are developed. It is shown that the proposed finite-frequency design scheme can achieve a better disturbance- suppression performance in restricted frequency ranges than the existing ones, which is illustrated by an example about the satellite system.
Static Output Feedback for Discrete-time Switched Linear Systems under Arbitrary Switching
Guang-Hong Yang,Da-Wei Ding 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2
This paper considers the problem of static output feedback (SOF) control for discrete-time switched linear systems under arbitrary switching. By the aid of switched quadratic Lyapunov functions combined with Finsler’s lemma, new sufficient conditions for SOF stabilization are obtained which guarantee a r-performance of the closed-loop switched systems subject to input disturbances. The proposed method can work successfully in situations where the existing ones fail. Three examples are given to illustrate its effectiveness.