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      • Bismuth oxyhalides: synthesis, structure and photoelectrochemical activity

        Bhachu, D.,Moniz, S. A.,Sathasivam, S.,Scanlon, D.,Walsh, A.,Bawaked, S.,Mokhtar, M.,Obaid, A.,Parkin, I.,Tang, J. THE ROYAL SOCIETY OF CHEMISTRY 2016 Chemical Science Vol.7 No.8

        <P>We report the synthesis and photoelectrochemical assessment of phase pure tetragonal matlockite structured BiOX (where X = Cl, Br, I) films. The materials were deposited using aerosol-assisted chemical vapour deposition. The measured optical bandgaps of the oxyhalides, supported by density functional theory calculations, showed a red shift with the increasing size of halide following the binding energy of the anion p-orbitals that form the valence band. Stability and photoelectrochemical studies carried out without a sacrificial electron donor showed the n-type BiOBr film to have the highest photocurrent reported for BiOBr in the literature to date (0.3 mA cm(-2) at 1.23 V vs. RHE), indicating it is an excellent candidate for solar fuel production with a very low onset potential of 0.2 V vs. RHE. The high performance was attributed to the preferred growth of the film in the [011] direction, as shown by X-ray diffraction, leading to internal electric fields that minimize charge carrier recombination.</P>

      • Engineering requirements due to the ESP/ESPN regulation apply at the port plug for ITER diagnostic system

        Giacomin, T.,Delhom, D.,Drevon, J.-M.,Guirao, J.,Iglesias, S.,Jourdan, T.,Loesser, D.,Maquet, P.,Ordieres, J.,Pak, S.,Proust, M.,Smith, M.,Udintsev, V.S.,Vacas, C.,Walsh, M.J.,Zhai, Y. Elsevier 2015 Fusion engineering and design Vol.98 No.-

        <P><B>Abstract</B></P> <P>Due to this position close to the plasma, the port plug structure and the diagnostic first wall (DFW) contain water to allow cooling during operation and for heating during bake-out. To remove the heat coming from the plasma due to radiation and neutrons, the pressure inside these structures should be up to 44 bars. On the other hand, the dominant load expected to drive the design of these structures is of electromagnetic origin during the plasma disruption. Description of the loads acting on DFWs and generic port plug structures and the significance of the load due to the water pressure, with implications on the design and inspection, are discussed in this paper.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The ESP/ESPN regulation is applied to all equatorial and upper port-based diagnostic systems. </LI> <LI> The EPP and UPP structure provides a flexible platform for a variety of diagnostics. </LI> <LI> The EPP and UPP structure provide a support the diagnostic shielding module. </LI> </UL> </P>

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        Enzymatic synthesis of chlorogenic acid glucoside using dextransucrase and its physical and functional properties

        Nam, S.H.,Ko, J.A.,Jun, W.,Wee, Y.J.,Walsh, M.K.,Yang, K.Y.,Choi, J.H.,Eun, J.B.,Choi, J.,Kim, Y.M.,Han, S.,Nguyen, T.T.H.,Kim, D. IPC Science and Technology Press 2017 Enzyme and microbial technology Vol.107 No.-

        <P>Chlorogenic acid, a major polyphenol in edible plants, possesses strong antioxidant activity, anti-lipid peroxidation and anticancer effects. It used for industrial applications; however, this is limited by its instability to heat or light. In this study, we for the first time synthesized chlorogenic acid glucoside (CHG) via transglycosylation using dextransucrase from Leuconostoc mesenteroides and sucrose. CHG was purified and its structure determined by nuclear magnetic resonance and matrix-associated laser desorption ionization time-of-flight mass spectroscopy. The production yield of CHG was 44.0% or 141 mM, as determined by response surface methodology. CHG possessed a 65% increased water solubility and 2-fold browning resistance while it displayed stronger inhibition of lipid peroxidation and of colon cancer cell growth by MTT assay, compared to chlorogenic acid. Therefore, this study may expand the industrial applications of chlorogenic acid as water-soluble or browning resistant compound (CHG) through enzymatic glycosylation.</P>

      • KCI등재후보

        Ion-induced emission microscopies

        B.L.Doyle,D.S.Walsh,G.Vizkelethy,P.Rossi,F.D.McDaniel,T.Schenkel,J.McDonald,A.V.Hamza 한국물리학회 2003 Current Applied Physics Vol.3 No.1

        New emission-based MeV nuclear microscopies have been in the process of development for the past four years. These techniques all fall under the heading of ion-induced emission microscopy (I-IEM), and the first to be developed was ion-electron emission microscopy (IEEM). With I-IEM the ion beam is not focused, but instead, secondary particles emitted when a single-ion strikes the sample are projected at great magnification onto a high efficiency single particle detector generating position signals. These X and Y signals are then put into coincidence with other signals made by this same ion in a fashion completely analogous to traditional nuclear microprobe analysis. In this paper, we update the current state of I-IEMs, which currently includes IEEM and highly charged ion-secondary ion mass spectroscopy (HCI-SIMS or IIEM) and ion-photon emission microscopy. At the present time none of these microscopies have atomic resolution, but the potential exists for resolution adequate for many scientific and nanotechnology applications. 2002 Elsevier Science B.V. All rights reserved.

      • Benchmarking of Mechanical Test Facilities Related to ITER CICC Steel Jackets

        Vostner, A.,Pong, I.,Bessette, D.,Devred, A.,Sgobba, S.,Jung, A.,Weiss, K.,Jewell, M. C.,Liu, S.,Yu, W.,Boutboul, T.,Hamada, K.,Park, S.,Tronza, V.,Walsh, R. P. IEEE 2013 IEEE transactions on applied superconductivity Vol.23 No.3

        <P>The International Thermonuclear Experimental Reactor (ITER) cable-in-conduit conductor used in the superconducting magnet system consists of a cable made of 300 to 1440 strands housed in a stainless steel tube (called as jacket or conduit). There are circular, square, as well as circle-in-square jackets, made of either a very low carbon AISI 316LN and AISI 316L grade stainless steels, or a high Mn austenitic stainless steel developed for ITER called JK2LB. Selected mechanical properties of the base material and weld joint were tested at room temperature and/or cryogenic temperatures (<; 7 K) at predefined mechanical deformation and heat treatment condition. The domestic agencies' reference laboratories and the ITER-IO appointed reference laboratories, CERN and Karlsruhe Institute of Technology performed mechanical tests such as tensile strength, fracture toughness, and fatigue crack growth rate. This paper will compare the test results (e.g., elongation to failure) from different laboratories, present the statistics, and identify any systematic differences.</P>

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        VEGF-Induced Vascular Permeability Is Mediated by FAK

        Chen, X.,Nam, J.O.,Jean, C.,Lawson, C.,Walsh, Colin T.,Goka, E.,Lim, S.T.,Tomar, A.,Tancioni, I.,Uryu, S.,Guan, J.L.,Acevedo, Lisette M.,Weis, Sara M.,Cheresh, David A.,Schlaepfer, David D. Cell Press 2012 DEVELOPMENTAL CELL Vol.22 No.1

        Endothelial cells (ECs) form cell-cell adhesive junctional structures maintaining vascular integrity. This barrier is dynamically regulated by vascular endothelial growth factor (VEGF) receptor signaling. We created an inducible knockin mouse model to study the contribution of the integrin-associated focal adhesion tyrosine kinase (FAK) signaling on vascular function. Here we show that genetic or pharmacological FAK inhibition in ECs prevents VEGF-stimulated permeability downstream of VEGF receptor or Src tyrosine kinase activation in vivo. VEGF promotes tension-independent FAK activation, rapid FAK localization to cell-cell junctions, binding of the FAK FERM domain to the vascular endothelial cadherin (VE-cadherin) cytoplasmic tail, and direct FAK phosphorylation of β-catenin at tyrosine-142 (Y142) facilitating VE-cadherin-β-catenin dissociation and EC junctional breakdown. Kinase inhibited FAK is in a closed conformation that prevents VE-cadherin association and limits VEGF-stimulated β-catenin Y142 phosphorylation. Our studies establish a role for FAK as an essential signaling switch within ECs regulating adherens junction dynamics.

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