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Rewiring of Genetic Networks in Response to DNA Damage
Bandyopadhyay, S.,Mehta, M.,Kuo, D.,Sung, M.-K.,Chuang, R.,Jaehnig, E. J.,Bodenmiller, B.,Licon, K.,Copeland, W.,Shales, M.,Fiedler, D.,Dutkowski, J.,Guenole, A.,van Attikum, H.,Shokat, K. M.,Kolodner American Association for the Advancement of Scienc 2010 Science Vol.330 No.6009
<P>Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go undetected in static conditions. They are very effective at identifying DNA repair pathways, highlighting new damage-dependent roles for the Slt2 kinase, Pph3 phosphatase, and histone variant Htz1. The data also reveal that protein complexes are generally stable in response to perturbation, but the functional relations between these complexes are substantially reorganized. Differential networks chart a new type of genetic landscape that is invaluable for mapping cellular responses to stimuli.</P>
K. Saxena,Gyanendra Singh,B. Thallapaka,D.S. Mehta 한국정보디스플레이학회 2014 Journal of information display Vol.15 No.3
A single-emissive fluorescent layer co-doped with red and blue phosphorescent dyes in a host [4, 4, bis-9 carbozyl-biphenyl](CBP) was used to fabricate white organic light-emitting devices (WOLEDs). The electroluminescent spectrum of thegenerated white light was observed to have two spectral peaks at ∼495 and ∼590 nm and a dip at ∼536 nm, with differentthicknesses of the emissive layer (EML). By optimizing the ratio of the dopants in the EML, the ratio of the maximumintensity of the two spectral peaks was brought to unity. The Commission Internationale de l’Eclairage (CIE) coordinatesand correlated color temperature of the fabricated device were calculated, and the results are reported herein. No significantchange in the spectral shape of the emission spectra and the CIE coordinates were obtained when the applied voltages werevaried. It is easier to fabricate WOLEDs with a single EML as compared with their multilayer counterparts.
Internet search analytics for shoulder arthroplasty: what questions are patients asking?
Johnathon R. McCormick,Matthew C. Kruchten,Nabil Mehta,Dhanur Damodar,Nolan S. Horner,Kyle D. Carey,Gregory P. Nicholson,Nikhil N. Verma,Grant E Garrigues 대한견주관절학회 2023 대한견주관절의학회지 Vol.26 No.1
Background: Common questions about shoulder arthroplasty (SA) searched online by patients and the quality of this content are unknown. The purpose of this study is to uncover questions SA patients search online and determine types and quality of webpages encountered. Methods: The “People also ask” section of Google Search was queried to return 900 questions and associated webpages for general, anatomic, and reverse SA. Questions and webpages were categorized using the Rothwell classification of questions and assessed for quality using the Journal of the American Medical Association (JAMA) benchmark criteria. Results: According to Rothwell classification, the composition of questions was fact (54.0%), value (24.7%), and policy (21.3%). The most common webpage categories were medical practice (24.6%), academic (23.2%), and medical information sites (14.4%). Journal articles represented 8.9% of results. The average JAMA score for all webpages was 1.69. Journals had the highest average JAMA score (3.91), while medical practice sites had the lowest (0.89). The most common question was, “How long does it take to recover from shoulder replacement?” Conclusions: The most common questions SA patients ask online involve specific postoperative activities and the timeline of recovery. Most information is from low-quality, non-peer-reviewed websites, highlighting the need for improvement in online resources. By understanding the questions patients are asking online, surgeons can tailor preoperative education to common patient concerns and improve postoperative outcomes.