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Room temperature single-step synthesis of metal decorated boron-rich nanowires via laser ablation
Mark H. Rummeli,Barbara Trzebicka,Gianaurelio Cuniberti,Thomas Gemming,Alicja Bachmatiuk,Ignacio G. Gonzalez-Martine 나노기술연구협의회 2019 Nano Convergence Vol.6 No.14
Hybrid nanostructures, such as those with nanoparticles anchored on the surface of nanowires, or decorated nanowires, have a large number of potential and tested applications such as: gas sensing, catalysis, plasmonic waveguides, supercapacitors and more. The downside of these nanostructures is their production. Generally, multi-step synthesis procedures are used, with the nanowires and the nanoparticles typically produced separately and then integrated. The few existent single-step methods are lengthy or necessitate highly dedicated setups. In this paper we report a single-step and rapid (ca. 1 min) laser ablation synthesis method which produces a wide variety of boron-rich decorated nanowires. Furthermore, the method is carried at room temperature. The synthesis process consists on a filamentary jet ejection process driven by pressure gradients generated by the ablation plume on the rims of the irradiation crater. Simultaneously nanoparticles are nucleated and deposited on the filaments thus producing hybrid decorated nanowires.
Cristina Vercelli,Raffaella Barbero,Barbara Cuniberti,Silvia Racca,Giuliana Abbadessa,Francesca Piccione,Giovanni Re 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4
Purpose: Transient receptor potential vanilloid 1 (TRPV1) is a nonselectivecation channel belonging to the transient receptor potentialfamily, and it is expressed in different neoplastic tissues. Its activation is associated with regulation of cancer growth andprogression. The aim of this research was to study the expressionand pharmacological characteristics of TRPV1 in cells derivedfrom human breast cancer MCF-7 cells. Methods: TRPV1presence was assessed by binding studies and Western blotting. Receptor binding characteristics were evaluated through competitionassays, while 3-(4,5-dimethylthiazol-2-yl)-2,5,-dipheyltetrazoliumbromide reduction assays were performed to confirman early hypothesis regarding the modulation of cancer cell proliferation. The functionality of TRPV1 was evaluated by measuringCa2+ uptake in the presence of increasing concentrations ofTRPV1 agonists and antagonists. Results: Binding studies identifieda single class of TRPV1 (Bmax 1,492±192 fmol/mg protein),and Western blot showed a signal at 100 kDa corresponding tothe molecular weight of human TRPV1. Among the different testedagonists and antagonists, anandamide (Ki: 2.8×10-11 M) and5-iodoresiniferatoxin (5-I-RTX) (Ki: 5.6×10-11 M) showed the highestdegrees of affinity for TRPV1, respectively. All tested TRPV1agonists and antagonists caused a significant (p<0.05) decreasein cell growth rate in MCF-7 cells. For agonists and antagonists,the efficacy of tested compounds displayed the following rankorder: resiniferatoxin>anandamide>capsaicin and 5-I-RTX=capsazepine, respectively. Conclusion: These data indicate thatboth TRPV1 agonists and antagonists induce significant inhibitionof MCF-7 cell growth. Even though the mechanisms involvedin the antiproliferative effects of TRPV1 agonists and antagonistsshould be further investigated, it has been suggestedthat agonists cause desensitization of the receptor, leading to alterationin Ca2+-influx regulation. By contrast, antagonists causea functional block of the receptor with consequent fatal dysregulationof cell homeostasis.
Single-molecule DNA conductance in water solutions: Role of DNA low-frequency dynamics
Starikov, E.B.,Quintilla, A.,Nganou, C.,Lee, K.H.,Cuniberti, G.,Wenzel, W. North Holland ; Elsevier Science Ltd 2009 Chemical physics letters Vol.467 No.4
Dependence of charge transmission through several experimentally studied DNA duplexes on their lowest-frequency acoustic modes, combined with the molecular dynamics in picosecond characteristic time range, has been studied. Based on this analysis we were able to identify the specific acoustic modes responsible for the noticeable increase in DNA charge transmission. Other factors influencing electric properties of DNA duplexes are discussed.
Electrical Conductance in Biological Molecules
Waleed Shinwari, M.,Jamal Deen, M.,Starikov, Evgeni B.,Cuniberti, Gianaurelio WILEY-VCH Verlag 2010 Advanced Functional Materials Vol.20 No.12
<P>Nucleic acids and proteins are not only biologically important polymers. They have recently been recognized as novel functional materials surpassing conventional materials in many aspects. Although Herculean efforts have been undertaken to unravel fine functioning mechanisms of the biopolymers in question, there is still much more to be done. Here the topic of biomolecular charge transport is presented with a particular focus on charge transfer/transport in DNA and protein molecules. The experimentally revealed details, as well as the presently available theories, of charge transfer/transport along these biopolymers are critically reviewed and analyzed. A summary of the active research in this field is also given, along with a number of practical recommendations.</P> <B>Graphic Abstract</B> <P>Biomolecular charge transport is presented, with a particular focus on charge transfer/transport in DNA and protein molecules. The experimental data, as well as the presently available theories, are critically reviewed and analyzed. A summary of the active research in this field is also given, along with a number of practical recommendations. <img src='wiley_img_2010/1616301X-2010-20-12-ADFM200902066-content.gif' alt='wiley_img_2010/1616301X-2010-20-12-ADFM200902066-content'> </P>
Popov, Alexey A.,Schiemenz, Sandra,Avdoshenko, Stanislav M.,Yang, Shangfeng,Cuniberti, Gianaurelio,Dunsch, Lothar American Chemical Society 2011 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.115 No.31
<P>While the role of asymmetric nitride clusters on the cage size and symmetry in fullerene-based structures is already well-known, the role of the asymmetric arrangement of metals in nitride clusters on the nitrogen is studied in detail in this work. It is discovered that asymmetric mixed-metal nitride clusters give sufficiently narrow <SUP>14</SUP>N NMR signals to make NMR the method of choice to characterize the endohedral cluster from the inside. In the series of mixed-metal nitride clusterfullerenes Lu<SUB><I>x</I></SUB>Sc<SUB>3–<I>x</I></SUB>N@C<SUB>80</SUB> and Lu<SUB><I>x</I></SUB>Y<SUB>3–<I>x</I></SUB>N@C<SUB>80</SUB> (<I>x</I> = 0–3) the δ(<SUP>14</SUP>N) values are found to be linear functions of <I>x</I> showing that <SUP>14</SUP>N chemical shifts are additive values with specific increment for each kind of metal atoms. Density functional theory calculations are performed to interpret the experimentally measured spectra. To reveal the main factors affecting <SUP>14</SUP>N chemical shifts in nitride clusterfullerenes, shielding tensor components are analyzed in terms of Ramsey theory both in localized and canonical molecular orbitals. <SUP>14</SUP>N chemical shifts in M<SUB>3</SUB>N@C<SUB>80</SUB> and related systems are shown to be determined solely by nitrogen-localized orbitals and in particular by the p<SUB><I>x,y,z</I></SUB> atomic orbitals of nitrogen. As a result, the peculiarities of the nitrogen shielding in nitride clusterfullerenes can be interpreted by the simple analysis of the nitrogen-projected density of states and its variation in different chemical environments.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2011/jpccck.2011.115.issue-31/jp204290f/production/images/medium/jp-2011-04290f_0004.gif'></P>