Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4–MyD88–NF-kB signaling pathway

Naigang Wang,Cuiping Geng,Haiyun Sun,Xia Wang,Fangmin Li,Xunchao Liu 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.12

Hesperetin, a major bioflavonoid in sweetoranges and lemons, exerts an anti-inflammatory effect inpulmonary diseases; however, its effect on lipopolysaccharide(LPS)-induced acute lung injury is unclear. This studyinvestigated the effect of hesperetin on LPS-induced lunginflammatory response. Mice were intratracheally instilledwith 5 mg/kg body weight LPS, and then were given hesperetinorally (10, 20, and 30 mg/kg body weight) 1 h later. Hesperetin dramatically suppressed the levels of interleukin-6 and tumor necrosis factor-α, as well as the number ofinflammatory cells in bronchoalveolar lavage fluid. Besides,it reduced lung injury, wet weight/dry weight ratio, andmyeloperoxidase and lactate dehydrogenase activities, andenhanced superoxide dismutase activity. In addition, hesperetinsignificantly downregulated the Toll-like receptor4 (TLR4) and myeloid differentiation factor 88 (MyD88)protein expression and suppressed nuclear factor-kappa B(NF-κB) activation in lung tissue. Together, these resultsindicated that the anti-inflammatory effect of hesperetin isassociated with the TLR4–MyD88–NF-κB pathway, andthat hesperetin shows therapeutic potential for LPS-inducedacute lung injury.

Controlled synthesis of porous Ni-doped SnO₂ microstructures and their enhanced gas sensing properties

Gu, Cuiping,Guan, Wenmei,Liu, Xiaosi,Gao, Lvlv,Wang, Liyou,Shim, Jae-Jin,Huang, Jiarui ELSEVIER SCIENCE 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.692 No.-

<P><B>Abstract</B></P> <P>Porous Ni-doped SnO<SUB>2</SUB> microspheres and microcubes were obtained via a facile chemical solution route followed by calcination and acid-washing process. Their structural and morphological evolution was characterized using a range of techniques. The process of inducing porosity began with crystalline single-phase NiSn(OH)<SUB>6</SUB> precursors formed by the co-precipitation of metal ions from an aqueous solution. Thermal decomposition of the precursors led to an intimate mixture of cubic phase NiO and tetragonal phase SnO<SUB>2</SUB>. The Ni-doped SnO<SUB>2</SUB> microspheres and microcubes were obtained after a simple acid-washing process. A decomposition–aggregation–dissolution process was proposed to explain the formation of these structures. The gas-sensing properties of the as-prepared porous Ni-doped SnO<SUB>2</SUB> microspheres and microcubes for toxic volatile organic compounds, such as formaldehyde, ethanol, benzene, methanol, acetone, and toluene, were investigated. The enhanced sensing performance of the porous Ni-doped SnO<SUB>2</SUB> microspheres was demonstrated. The detection limits of formaldehyde and ethanol were approximately 0.17 and 0.09 ppm (signal-to-noise ratio, S/N = 3), respectively. The enhanced sensing performance of the porous Ni-doped SnO<SUB>2</SUB> microspheres was attributed to their Ni-dopant, unique porous structure and large surface area.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Porous Ni-doped SnO<SUB>2</SUB> microstructures were obtained by treatment of the precursors. </LI> <LI> Porous Ni-doped SnO<SUB>2</SUB> microstructures exhibited excellent gas-sensing properties. </LI> <LI> Excellent gas-sensing properties were attributed to the Ni-dopant and 3D structures. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Porous Ni-doped SnO<SUB>2</SUB> microspheres and microcubes, obtained by a facile chemical solution route followed by calcination and acid-washing, showed excellent gas-sensing performances.</P> <P>[DISPLAY OMISSION]</P>

Ultrahigh Energy Storage Capacitance and High Breakdown Strength in Biaxially Oriented Poly(vinylidene fluoride) Using a High-Electric-Induced Technique

Hongwei Lu,Jianxin Du,Cuiping Yu,Xingping Wang,Yanlin Gao,Weizhong Xu,Aiping Liu,Xiaoxiao Lu,Yingxin Chen 한국고분자학회 2020 Macromolecular Research Vol.28 No.6

The development of high dielectric materials with high energy densities is a crucial research domain in the modern microelectronics and power systems. The objective of this work was to develop the highly ordered crystal orientations and large ferroelectric crystalline β/γ-phases in the biaxially oriented poly(vinylidene fluoride) (BOPVDF). Importantly, a high discharged energy density and high dielectric constant was achieved by using a high-electric-induced technique. A suitable poling electric field was applied to the BOPVDF films in order to enhance the breakdown strength. Remarkably, the BOPVDF film poled at the electric field of 113 MV m-1 achieved an unprecedented discharged energy density of 25.4 J cm-3 at an ultra-high electric field of 550 MV m-1, which is by far the highest value ever achieved in flexible polymer-based capacitor films. Comparatively, the unpoled BOPVDF and commercial biaxially oriented polypropylene (BOPP) exhibited only a discharged energy density of 7.9 J cm-3 and 1.2 J cm-3, respectively. This systematic study provides a new design paradigm to exploit PVDF-based dielectric polymers for capacitor applications.

THE ECONOMIC IMPACTS OF CARBON TRADING MECHANISM ON THE DEVELOPMENT OF PV PROJECTS IN GUANGDONG PROVINCE

Pengcheng XIE,Wenjun WANG,Daiqing ZHAO,Cuiping Liao 한국신재생에너지학회 2017 AFORE Vol.2017 No.11

Circular RNA circ_0000877 serves as a miR-671-5p sponge to regulate diffuse large B-cell lymphoma development via HK2

Zhou Weilun,Wu Cuiping,Wang Jiao 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3

Background Emerging evidence has revealed that circular RNAs (circRNAs) are critical regulators for the development of various tumors, containing diff use large B-cell lymphoma (DLBCL). CircRNA microarray analysis suggested that circ_0000877 was freakishly increased in DLBCL tissues. Objective This study is designed to explore the role and mechanism of circ_0000877 on DLBCL development. Results Circ_0000877 and HK2 were increased, and miR-671-5p was reduced in DLBCL tissues and cell lines. Also, circ_0000877 silencing hindered DLBCL cell proliferation and glycolysis, and induced apoptosis in vitro. Mechanically, circ_0000877 functioned as a sponge of miR-671-5p, and circ_0000877 knockdown-mediated DLBCL cell development inhibition was relieved by miR-671-5p downregulation. Moreover, HK2 acted as a direct target gene of miR-671-5p, and enhanced HK2 might abolish the impact of miR-671-5p on DLBCL cell progression. Conclusion Circ_0000877 silencing mitigated DLBCL cell malignant biological behavior partly via miR-671-5p/HK2 axis, referring to circ_0000877 as an underlying prognostic biomarker. These data provided a promising strategy for treating DLBCL malignancies.

Robust Gaussian Function Algorithm for Matrix Completion

Juan Geng,Mengxuan Zhao,Cuiping Nie,Laisheng Wang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.4

Preparation of porous flower-like SnO₂ micro/nano structures and their enhanced gas sensing property

Ren, Haibo,Zhao, Wei,Wang, Liyou,Ryu, Si Ok,Gu, Cuiping Elsevier 2015 JOURNAL OF ALLOYS AND COMPOUNDS Vol.653 No.-

<P><B>Abstract</B></P> <P>Porous flower-like tin oxide (SnO<SUB>2</SUB>) structures were obtained using a hydrothermal method combined with a subsequent calcination and acid-washing process. The morphologies and crystal structures of the products were characterized by field emission scanning electron microscopy, transmission electron microscopy, energy dispersive spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and Brunauer–Emmett–Teller N<SUB>2</SUB> adsorption-desorption analyses. The process of inducing porosity begins with a flower-like nickel tin sulfur precursor. Thermal decomposition of this flower-like nickel tin sulfur precursor leads to an intimate mixture of porous flower-like NiO/SnO<SUB>2</SUB> hybrids. Porous SnO<SUB>2</SUB> flowers were obtained after removing the cubic phase NiO by an acid-washing process. Furthermore, the gas sensing properties of the as-prepared porous SnO<SUB>2</SUB> flowers to VOCs, such as ethanol, formaldehyde, benzene, toluene, and acetone, were investigated. The porous SnO<SUB>2</SUB> flowers showed a good response and reversibility to some organic vapors, such as ethanol and formaldehyde. The sensing responses to 100 ppm ethanol and formaldehyde were 42.4 and 24.8, respectively. The sensors also exhibited a good response to benzene, toluene, methanol, and 2-propanol. The relationship between the gas-sensing properties and the microstructure of the as-prepared flower-like SnO<SUB>2</SUB> structures was also examined.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Flower-like nickel tin sulfur structures were synthesized by hydrothermal method. </LI> <LI> Porous SnO<SUB>2</SUB> microflowers were obtained by treatment of the precursor. </LI> <LI> Porous SnO<SUB>2</SUB> microflowers exhibited excellent sensing properties to some gases. </LI> <LI> Excellent gas-sensing properties were attributed to the special 3D structures. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Highly efficient removal of ionic dyes in aqueous solutions using magnetic 3D reduced graphene oxide aerogel supported nano zero-valent iron

Mingyi Fan,Peng Zhang,Cuiping Wang,Hongwen Sun 대한환경공학회 2024 Environmental Engineering Research Vol.29 No.1

DEVELOPMENT OF MAGNETICALLY RESPONSIVE Fe3O4@C CORE/SHELL MICROSPHERES AS POTENTIAL VECTORS FOR DRUG-DELIVERY APPLICATIONS

WENJING YUAN,LING ZHU,PING CHEN,ANJIAN XIE,HUI ZHANG,CUIPING WANG,YUHUA SHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.4

The Fe3O4@C core/shell microspheres were fabricated via a two-step process. Fe3O4 microspheres were firstly prepared, and Fe3O4@C core/shell microspheres were subsequently fabricated using glucose as a carbon source by a hydrothermal route, in which the thickness of the carbon coating was about 20 nm. The resulting products were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectra (FTIR). The Nitrogen adsorption–desorption isotherms reveal their mesoporous structure and larger BET surface area (62.3 m2g-1). The Fe3O4@C core/shell microspheres possess ferromagnetism and high saturation magnetization (39.2 emu ⋅ g-1). Bovine hemoglobin (BHb) was used as a model protein to test the adsorption and desorption properties of the Fe3O4@C core/shell microspheres. The capacity for BHb adsorption was more than 71.3 mg/g. According to the values obtained in the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay the Fe3O4@C core/shell microspheres show a low toxicity. Therefore, the prepared Fe3O4@C core/shell microspheres are of great significance for guided site-specific drug delivery.