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Silventoinen, Karri,Jelenkovic, Aline,Sund, Reijo,Yokoyama, Yoshie,Hur, Yoon-Mi,Cozen, Wendy,Hwang, Amie E,Mack, Thomas M,Honda, Chika,Inui, Fujio,Iwatani, Yoshinori,Watanabe, Mikio,Tomizawa, Rie,Piet American Society for Clinical Nutrition 2017 The American journal of clinical nutrition Vol.106 No.2
<P><B>Background:</B> Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m<SUP>2</SUP>)], but factors modifying these variance components are poorly understood.</P><P><B>Objective:</B> We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.</P><P><B>Design:</B> We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs).</P><P><B>Results:</B> The heritability of BMI decreased from 0.77 (95% CI: 0.77, 0.78) and 0.75 (95% CI: 0.74, 0.75) in men and women 20–29 y of age to 0.57 (95% CI: 0.54, 0.60) and 0.59 (95% CI: 0.53, 0.65) in men 70–79 y of age and women 80 y of age, respectively. The relative influence of unique environmental factors correspondingly increased. Differences in the sets of genes affecting BMI in men and women increased from 20–29 to 60–69 y of age. Mean BMI and variances in BMI increased from the 1940s to the 2000s and were greatest in North America and Australia, followed by Europe and East Asia. However, heritability estimates were largely similar over measurement years and between regions. There was no evidence of environmental factors shared by co-twins affecting BMI.</P><P><B>Conclusions:</B> The heritability of BMI decreased and differences in the sets of genes affecting BMI in men and women increased from young adulthood to old age. The heritability of BMI was largely similar between cultural-geographic regions and measurement years, despite large differences in mean BMI and variances in BMI. Our results show a strong influence of genetic factors on BMI, especially in early adulthood, regardless of the obesity level in the population.</P>
International Network of Twin Registries (INTR): Building a Platform for International Collaboration
Buchwald, Dedra,Kaprio, Jaakko,Hopper, John L.,Sung, Joohon,Goldberg, Jack,Fortier, Isabel,Busjhan, Andreas,Sumathipala, Athula,Cozen, Wendy,Mack, Thomas,Craig, Jeffrey M.,Harris, Jennifer R. Cambridge University Press 2014 TWIN RESEARCH AND HUMAN GENETICS - Vol.17 No.6
<P>The International Network of Twin Registries (INTR) aims to foster scientific collaboration and promote twin research on a global scale by working to expand the resources of twin registries around the world and make them available to researchers who adhere to established guidelines for international collaboration. Our vision is to create an unprecedented scientific network of twin registries that will advance knowledge in ways that are impossible for individual registries, and includes the harmonization of data. INTR will also promote a broad range of activities, including the development of a website, formulation of data harmonization protocols, creation of a library of software tools for twin studies, design of a search engine to identify research partners, establishment of searchable inventories of data and biospecimens, development of templates for informed consent and data sharing, organization of symposia at International Society of Twin Studies conferences, support for scholar exchanges, and writing grant proposals.</P>