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- 저자 : Clifford J. Rosen (검색결과 2 건)
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New Insights into Calorie Restriction Induced Bone Loss
Clifford J. Rosen,Linyi Liu 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.2
Caloric restriction (CR) is now a popular lifestyle choice due to its ability in experimental animals to improve lifespan, reduce bodyweight, and lessen oxidative stress. However, more and more emerging evidence suggests this treatment requires careful consideration because of its detrimental effects on the skeletal system. Experimental and clinical studies show that CR can suppress bonegrowth and raise the risk of fracture, but the specific mechanisms are poorly understood. Reduced mechanical loading has long beenthought to be the primary cause of weight loss-induced bone loss from calorie restriction. Despite fat loss in peripheral depots withcalorie restriction, bone marrow adipose tissue (BMAT) increases, and this may play a significant role in this pathological process. Here, we update recent advances in our understanding of the effects of CR on the skeleton, the possible pathogenic role of BMAT inCR-induced bone loss, and some strategies to mitigate any potential side effects on the skeletal system.
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Amina El Ayadi,Ron C. Helderman,Celeste C. Finnerty,David N. Herndon,Clifford J. Rosen,Gordon L. Klein 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.3
Objectives: The objective of the study was to determine whether postburn reduction of bone formation occurred earlier than 2e3 weeks after burn injury and whether that reduction was inversely related to marrow adiposity. Methods: Using a rat model of burn injury with sacrifice at 3 days postburn, we measured serum osteocalcin, a biomarker of bone formation, as well as a regulator of glucose metabolism, and counted tibial marrow adipocytes. Results: Serum osteocalcin was reduced as early as 3 days postburn, coinciding with a trend toward decline in marrow adipocyte number rather than demonstrating an inverse relationship with adipocyte count. Conclusions: Factors that may be responsible for the dissociation include lack of circulating sclerostin, previously reported, increased energy demands following burn injury, increased sympathetic tone and perhaps oxidative stress. The relationship between bone formation and marrow adiposity is complex and subject to a variety of influences.
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