http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Impact of hematologic toxicities during concurrent chemoradiation for cervical cancer
Feiya Shi,Alison K. Yoder,Claire Mach,Shraddha Dalwadi,Matthew L Anderson,Tracilyn R Hall,Michelle S Ludwig 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.2
ObjectiveTo evaluate the prognostic significance of hematological toxicities during cervical cancer treatment. MethodsPatients treated for cervical carcinoma with definitive chemoradiation were identified. Toxicities were assessed duringweeks 1 to 6 of concurrent external beam radiation and chemotherapy. Outcomes were analyzed using Cox regressionanalysis. ResultsOne hundred twenty-one patients with Federation of Gynecology and Obstetrics stage I-III disease were eligible foranalysis. Median age at diagnosis was 45 years (interquartile range, 40-52) with median follow-up time of 34 months(95% confidence interval, 30.8-37.2). All patients experienced some grade of hematologic toxicity. The most commongrade 3+ toxicities were low absolute lymphocyte count (n=115, 95%), low white blood cell count (n=21, 17%), andanemia (n=11, 9%). The most common grade 4 toxicity was lymphopenia, experienced by 36% of patients (n=44). Grade 4 lymphopenia was associated with reduced overall survival (hazard ratio [HR], 4.5; P=0.005), progressionfreesurvival (HR, 3.4; P=0.001), and local control (HR, 4.1; P=0.047). Anemia grade 3, 4 was also associated withreduced overall survival (HR, 4.1; P=0.014). After controlling for disease and treatment variables, grade 4 lymphopeniaremained significantly associated with reduced overall survival (HR, 9.85; P=0.007). The association with grade 4lymphopenia only remained significant in women of Hispanic ethnicity. ConclusionSevere lymphopenia was associated with reduced overall survival and progression-free survival in Hispanic womenundergoing definitive chemoradiation for cervical cancer, but not associated with outcomes in non-Hispanic women.
Li Shean Toh,Pauline Siew Mei Lai,David Bin-Chia Wu,Brian G. Bell,Cuu Phuong Linh Dang,Bee Yean Low,Kok Thong Wong,Giuseppe Guglielmi,Claire Anderson 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.3
Objectives: To compare and assess the performance of 6 osteoporosis risk assessment tools for screening osteoporosis in Malaysian postmenopausal women. Methods: Six osteoporosis risk assessments tools (the Simple Calculated Osteoporosis Risk Estimation [SCORE], the Osteoporosis Risk Assessment Instrument, the Age Bulk One or Never Estrogen, the body weight, the Malaysian Osteoporosis Screening Tool, and the Osteoporosis Self-Assessment Tool for Asians) were used to screen postmenopausal women who had not been previously diagnosed with osteoporosis/osteopenia. These women also underwent a dual-energy X-ray absorptiometry (DXA) scan to confirm the absence or presence of osteoporosis. Results: A total of 164/224 participants were recruited (response rate, 73.2%), of which only 150/164 (91.5%) completed their DXA scan. Sixteen participants (10.7%) were found to have osteoporosis, whilst 65/150 (43.3%) were found to have osteopenia. Using precision-recall curves, the recall of the tools ranged from 0.50 to 1.00, whilst precision ranged from 0.04 to 0.14. The area under the curve (AUC) ranged from 0.027 to 0.161. The SCORE had the best balance between recall (1.00), precision (0.04e0.12), and AUC (0.072e0.161). Conclusions: We found that the SCORE had the best balance between recall, precision, and AUC among the 6 screening tools that were compared among Malaysian postmenopausal women.