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Jaqueline Correia Villac¸a,Luiz Cla´udio R. Pereira da Silva,Luisa Helena Falca˜o Barbosa,Carlos Rangel Rodrigues,Luiz Marcelo Lira,Fla´ via Almada do Carmo,Valeria Pereira de Sousa,Maria Ineˆs Bruno 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.6
The purpose of this study was to prepare and characterize lamellar silicate nanocomposites usingexfoliation processes, high clay load and polyvinylpyrrolidone (PVP), ethylcellulose (EC) andpolyquaternium-H (PQH). The clays (sodium montmorillonite, Viscogel S4TM, S7TM and B8TM) werepre-treated with ultrasonic energy in order to increase clay exfoliation yields. Polymeric nanocompositeswere characterized by XRPD, DSC, TGA, DLS and NMR. The results revealed a new exfoliationmethod and new intercalated nanocomposites. High clay load was used to obtain the nanocomposites,which enables its application at an industrial scale. These nanocomposites could be broadly appliedacross the pharmaceutical, medical and food industries.
Rosália Rubel,Herta S. Dalla Santa,Sandro J.R. Bonatto,Se´rgio Bello,Luiz Cla´udio Fernandes,Raffaello Di Bernardi,Juliana Gern,Cid Aimbire´ M. Santos,Carlos Ricardo Soccol 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
This study investigated the effect of Ganoderma lucidum supplementation on lymphocytes and peritoneal macrophages from mice. Our results show that G. lucidum in vivo was able to increase interferon-γ (IFN-γ) concentration but reduced CD3+ and CD8+ spleen lymphocytes. Ex vivo, IFN-γ; and interleukin-10 levels were increased and the tumor necrosis factor-α (TNF-α) level was reduced by peritoneal macrophages from mice fed with G. lucidum. In the absence of stimuli nitric oxide production was reduced in mice fed with G. lucidum, and with lipopolysaccharide stimulation nitric oxide production was increased but was lower than control values (P<.05). G. lucidum was grown by solid-state culture in wheat grain, and a chow containing 10% G. lucidum mycelium was formulated (G10). Swiss male mice were divided into two groups, termed G10 and control groups according to the diet, and were fed for 3 months. Peritoneal macrophages were obtained and investigated with regard to phagocytosis, lysosomal volume, hydrogen peroxide, superoxide anion, and cytokines ex vivo. In the plasma we investigated concentrations of cytokines, and in the spleen we determined subsets of CD3+, CD4+, CD8+, and CD19+ lymphocytes.
Fares Zeida´n-Chulia,Mutlu Keskin,Eija Ko¨no¨nen,Veli-Jukka Uitto,Eva So¨derling,Jose´ Cla´udio Fonseca Moreira,Ulvi K. Gu¨rsoy 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4
The present report examined the effects of essential oils (EOs) from Satureja hortensis L. and Salvia fruticosa M. on the viability and outer membrane permeability of the periodontopathogen Fusobacterium nucleatum, a key bacteria in oral biofilms, as well as the inhibition of matrix metalloproteinase (MMP-2 and MMP-9) activities in epithelial cells exposed to such bacteria. Membrane permeability was tested by measuring the N-phenyl-1-naphthylamine uptake and bacterial viability by using the commercially available Live/Dead BacLight kit. In addition, gelatin zymography was performed to analyze the inhibition of F. nucleatum-induced MMP-2 and MMP-9 activities in HaCaT cells. We showed that 5, 10, and 25 μL/mL of Sat. hortensis L. EO decreased the ratio of live/dead bacteria and increased the outer membrane permeability in a range of time from 0 to 5 min. Treatments with 10 and 25 μL/mL of Sal. fruticosa M. also increased the membrane permeability and 5, 10, and 25 μL/mL of both EOs inhibited MMP-2 and MMP-9 activities in keratinocytes induced after exposure of 24 h to F. nucleatum. We conclude that antibacterial and antigelatinolytic activities of Sat. hortensis L. EO have potential for the treatment of periodontal inflammation.
The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review
Daiene Santos Buglio,Ledyane Taynara Marton,Lucas Fornari Laurindo,Elen Landgraf Guiguer,Adriano Cressoni Arau´jo,Roge´rio Leone Buchaim,Ricardo de Alvares Goulart,Cla´udio Jose´ Rubira,Sandra M. Barb 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.8
Advancing age is one of the risk factors for developing many diseases, including cancer, cardiovascular disorders, and neurodegenerative alterations, such as mild cognitive impairment (MCI), and Alzheimer's Disease (AD). Studies have indicated that supplementation with resveratrol (RSV) might improve cerebrovascular function and reduce the risk of developing dementia. Thus, the aim of this systematic review was to assess the effects of RSV on MCI and AD. MEDLINE-PubMed, Cochrane, and EMBASE were used to perform the search, and PRISMA guidelines were followed. Five studies met the eligible criteria; three with AD and two with MCI. In AD patients, the use of RSV reduces Aβ levels, improves brain volume, reduces the Mini-mental status score, and improves AD scores. In patients with MCI, this polyphenol prevents decline in Standard Volumes of Interest and increases the Resting-state Functional Connectivity score. RSV can activate the human silent information regulator 2/sirtuin 1 (Sirt-1) and can inhibit the cyclooxygenase-2 (COX-2), 5-lipoxygenase, and nuclear factor-κB, resulting in the reduction of the proinflammation pathways. It is also associated with the increase in the levels of interleukin (IL)-10 and reduction of interferon-γ and IL-17. Both anti-inflammatory and antioxidant effects can be related to preventing neurodegenerative diseases, doing maintenance, and enabling the recovery of these conditions directly related to inflammation and oxidative stress. We suggest that the use of RSV can bring beneficial effects to patients with MCI or AD.