Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients

Ilenia Cirilli,Sonia Silvestri,Fabio Marcheggiani,Fabiola Olivieri,Roberta Galeazzi,Roberto Antonicelli,Rina Recchioni,Fiorella Marcheselli,Tiziana Bacchetti,Luca Tiano,Patrick Orlando 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.6

Cardiovascular diseases represent the leading cause of death and moderate physical exercise is associated with a reduction in cardiovascular risk. The aim of the study was to evaluate the correlation between the amount of exercise recorded daily by a wearable gravitometer for 3 months and selected biochemical and clinical parameters. Nineteen sedentary type 2 diabetics were recruited and distributed into three homogenous groups, low, medium, and high exercise, according to the level of physical exercise monitored and expressed as MOVEs. Data showed an inverse correlation between MOVEs and oxidative stress indexes and a significant improvement in paraoxonase-1 activities and endothelial functionality. Decrease of visceral/total adipose tissue ratio, systolic blood pressure and a down-regulation of the inflammatory microRNA-146a in high exercise group were observed. Finally, a decrease of glycosylated hemoglobin and an up-regulation of the angiogenic microRNA-130a in medium exercise one was obtained. In this study, precise daily monitoring permitted to underline the importance of the amount of physical activity to counteract some cardiovascular risk factors persisting in diabetes. Finally, it identifies new microRNA biomarkers for future investigation on the same topic.

Upper Paleozoic glacigenic deposits of Gondwana: Stratigraphy and paleoenvironmental significance of a tillite succession in Northern Victoria Land (Antarctica)

Cornamusini, Gianluca,Talarico, Franco M.,Cirilli, Simonetta,Spina, Amalia,Olivetti, Valerio,Woo, Jusun Elsevier 2017 Sedimentary geology Vol.358 No.-

<P><B>Abstract</B></P> <P>Late Paleozoic glacial deposits are widespread in Gondwana. In Antarctica the best outcrops occur in the Central Transantarctic Mountains, Ellsworth Mountains, Pensacola Mountains, and in Southern Victoria Land, whereas they are rare and very scattered in Northern Victoria Land, which represents a linkage sector with Tasmania and eastern Australia. The aim of the present research is to define the stratigraphic setting and the environmental interpretation of a poorly studied Lower Permian glacigenic succession located near Orr Glacier in the Lanterman Range in Northern Victoria Land. It has great importance because it represents the only significant glacigenic succession for this wide area, marking and defining time and modality of a glacial-postglacial transition during the early Permian, a critical time-interval in the paleoenvironmental evolution of southern Gondwana. This succession, named here as the Lanterman Formation, lies directly on to crystalline basement, and is overlain by a thick Permian fluvial succession (Takrouna Formation). The results provided by sedimentological facies analysis and palynological analysis, integrated with a limited petrographic characterization, show a correlation framework between two isolated successions, outlining their stratigraphic architecture and subdivided into a lower glacial portion and an upper postglacial portion. The former, Asselian in age, is dominated by diamictite, sandstone, mudstone with lonestones, and carbonate deposits, suggesting repeated advance and retreat of a terrestrial glacier, with facies associations indicating environmental changes from subglacial to glaciofluvial, to glaciolacustrine. The latter is dominated by lacustrine mudstone with decreasing lonestones upward, thin bedded sandstone, conglomerate and a thick fluvial sandstone and pebbly sandstone succession at the top, signalling the transition to a fluvial system through time. The overall dataset suggests that the late Paleozoic glacigenic deposits of Northern Victoria Land record the evolution from a setting characterized by a terrestrial small ice cap that underwent repeated advances and retreats due to climate cycles in a lacustrine setting, into a postglacial paleoenvironmental scenario with a wide fluvial system draining northwards from Victoria Land towards the Tasmanian Basin. The results contribute to increasing knowledge of the timing and modalities of the Late Paleozoic Ice Age in Gondwana, particularly for polar regions such as Antarctica.</P>

Risk of Second Primary Malignancy in Breast Cancer Survivors: A Nested Population-Based Case-Control Study

Raffaella Marcheselli,Luigi Marcheselli,Laura Cortesi,Alessia Bari,Claudia Cirilli,Samantha Pozzi,Paola Ferri,Martina Napolitano,Massimo Federico,Stefano Sacchi 한국유방암학회 2015 Journal of breast cancer Vol.18 No.4

Purpose: Evolving therapies have improved the prognoses of patients with breast cancer; and currently, the number of longterm survivors is continuously increasing. However, these patients are at increased risk of developing a second cancer. Thus, late side effects are becoming an important issue. In this study, we aimed to investigate whether patient and tumor characteristics, and treatment type correlate with secondary tumor risk. Methods: This case-control study included 305 patients with a diagnosed second malignancy after almost 6 months after the diagnosis of primary breast cancer and 1,525 controls (ratio 1:5 of cases to controls) from a population-based cohort of 6,325 women. The control patients were randomly selected from the cohort and matched to the cases according to age at diagnosis, calendar period of diagnosis, disease stage, and time of followup. Results: BRCA1 or BRCA2 mutation, human epidermal growth factor receptor 2 (HER2)+ status, chemotherapy, and radiotherapy were related to increased risk of developing a second cancer, whereas hormonotherapy showed a protective effect. Chemotherapy, radiotherapy, and estrogenic receptor level <10% increased the risk of controlateral breast cancer. HER2+ status increased the risk of digestive system and thyroid tumors, while BRCA1 or BRCA2 mutation increased the risk of cancer in the genital system. Conclusion: Breast cancer survivors are exposed to an excess of risk of developing a second primary cancer. The development of excess of malignancies may be related either to patient and tumor characteristics, such as BRCA1 or BRCA2 mutation and HER2+ status, or to treatments factors.

Increased Incidence of Breast Cancer in Postmenopausal Women with High Body Mass Index at the Modena Screening Program

Federica Sebastiani,Laura Cortesi,Milena Sant,Valeria Lucarini,Claudia Cirilli,Elisabetta De Matteis,Isabella Marchi,Rossella Negri,Ennio Gallo,Massimo Federico 한국유방암학회 2016 Journal of breast cancer Vol.19 No.3

Purpose: We conducted a study to evaluate the relationship between body mass index (BMI) and the risk of breast cancer (BC) and outcome in a population of 14,684 women aged 55 to 69 years eligible to participate in the Mammography Screening Program (MSP) in the Province of Modena, Italy. Methods: The study population was drawn from women who underwent mammography screening between 2004 and 2006 in the Province of Modena. Women were subdivided into obese, overweight, and normal-weight categories according to BMI and followed until July 31, 2010, to evaluate the BC incidence. The clinicopathological characteristics of BC were also evaluated in different groups of patients classified according to BMI. After BC diagnosis, patients were followed for a median period of 65 (range, 2–104) months. Second events (recurrences and second tumors) were recorded, and the 5-year event-free survival (EFS) was calculated. Results: After a period of 73 months, 366 cases of BC were diagnosed. Compared with normal-weight women, obese women had a significantly higher incidence of BC (relative risk [RR], 1.32; p=0.040) (RR=1), larger tumors (27% of tumors were larger than T2 size), and more nodal involvement (38.5% of tumors were node-positive). Furthermore, a significantly higher rate of total events was seen in obese women compared with overweight and normal-weight patients, respectively (17.9% vs. 11.4% vs. 10.8%, p=0.032). The 5-year EFS was 89.0%, 89.0%, and 80.0% for normal-weight, overweight, and obese patients, respectively. Conclusion: We observed a significantly higher risk of BC in obese women among those eligible to participate in the MSP in the Province of Modena. Finally, obese women had more second events and poorer EFS compared to nono bese women.