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Choi, Dukhyun,Choi, Min-Yeol,Choi, Won Mook,Shin, Hyeon-Jin,Park, Hyun-Kyu,Seo, Ju-Seok,Park, Jongbong,Yoon, Seon-Mi,Chae, Seung Jin,Lee, Young Hee,Kim, Sang-Woo,Choi, Jae-Young,Lee, Sang Yoon,Kim, Jo WILEY-VCH Verlag 2010 ADVANCED MATERIALS Vol.22 No.19
<B>Graphic Abstract</B> <P>The cover shows an image of fully rollable transparent nanogenerators synthesized using chemical vapor deposition grown large-scale graphene sheets as transparent electrodes and piezoelectric ZnO nanorod arrays. Sang-Woo Kim, Jae-Young Choi, and co-workers report on p. 2187 the electrical and structural stability of the nanogenerators, with excellent charge scavenging performance under external mechanical loads such as bending and rolling. This study shows that graphene-based nanogenerators are very promising for self-powered rollable transparent device applications. <img src='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content.gif' alt='wiley_img_2010/09359648-2010-22-19-ADMA201090066-content'> </P>
Effect of the Ethanol Extract of Propolis on Formation of Streptococcus mutans Biofilm
Bog-Im Park,Yeon-Woo Jung,Young-Hoi Kim,Sang-Moo Lee,Lee-Seong Kwon,Kang-Ju Kim,So-Youn An,Na-Young Choi6,Yong-Ouk You 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4
Streptococcus mutans (S. mutans) is one of the most important bacteria in the formation of dental plaque and dental caries. S. mutans adheres to an acquired pellicle formed on the tooth surface, and aggregates with many oral bacteria. It initiates plaque formation by synthesizing glucan from sucrose, which is catalyzed by glucosyltransferases. Propolis is a resinous mixture produced by honeybees, by mixing saliva and beeswax with secretions gathered from wood sap and flower pollen. Bees prevent pathogenic invasions by coating the propolis to the outer and inner surface of the honeycomb. Propolis has traditionally been used for the treatment of allergic rhinitis, asthma and dermatitis. We investigated the inhibitory effects of propolis ethanol extract on biofilm formation and gene expression of S. mutans. The biofilm formation of S. mutans was determined by scanning electron microscopy (SEM) and safranin staining. We observed that the extract of propolis had an inhibitory effect on the formation of S. mutans biofilms at concentrations higher than 0.2 mg/ml. Real-time PCR analysis showed that the gene expression of biofilm formation, such as gbpB, spaP, brpA, relA and vicR of S. mutans, was significantly decreased in a dose dependent manner. The ethanol extract of propolis showed concentration dependent growth inhibition of S. mutans, and significant inhibition of acid production at concentrations of 0.025, 0.05, 0.1 and 0.2 mg/ml, compared to the control group. These results suggest that the ethanol extract of propolis inhibits gene expression related to biofilm formation in S. mutans.
Transcriptome analysis of a tropical medicinal plant, Pistacia weinmannifolia
Mi Kyung Choi(Mi Kyung Choi),Bimpe Suliyat Azeez(Bimpe Suliyat Azeez ),Sang Woo Lee(Sang Woo Lee),Wan Yi Li(Wan Yi Li),Sangho Choi(Sangho Choi),Ik-Young Choi(Ik-Young Choi),Ki-Young Choi(Ki-Young (사)한국식물생명공학회 2024 JOURNAL OF PLANT BIOTECHNOLOGY Vol.51 No.1
Choi, Chang Hyuck,Park, Sung Hyeon,Woo, Seong Ihl Royal Society of Chemistry 2011 GREEN CHEMISTRY Vol.13 No.2
<P>Heteroatom (nitrogen and sulfur)-doped carbons were synthesized <I>via</I> the pyrolysis of composites composed of iron chloride, cobalt chloride and five different amino acids (alanine, cysteine, glycine, niacine and valine), and their electrocatalytic activity towards oxygen reduction reactions (ORR) compared with each other for fuel cell applications. In all of the prepared catalysts, carbon was doped by nitrogen, and, in particular, a catalyst synthesized from cysteine was dual-doped with nitrogen and sulfur. Among all the catalysts, the dual-doped carbon showed the highest onset potential (0.55 V, <I>vs.</I> Ag/AgCl) and electrochemical activity in acidic media, − 0.2 mA (at 0.2 V, <I>vs.</I> Ag/AgCl), which is about 43% of that of commercial Pt/C (40 wt%). XPS revealed that sulfur was doped in the carbon as sulfate or sulfonate, and it is surmised that not only nitrogen doping but also sulfur doping of carbon plays a key role in improving its electrocatalytic activity towards ORR.</P> <P>Graphic Abstract</P><P>Not only nitrogen-doped carbons, but also nitrogen–sulfur dual-doped carbons, were synthesized from bio-derived amino acids. Their properties as catalysts of oxygen reduction reactions for fuel cells were investigated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0gc00384k'> </P>
Sung, Pil Soo,Choi, Hee Baeg,Kim, Su-Yeon,Hong, Sung Woo,Park, Chung-Hwa,Song, Myeong Jun,Lee, Sung Won,Yoo, Chan Ran,Choi, Sang Wook,Han, Nam Ik,Kim, Tai-Gyu,Yoon, Seung Kew The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11
<P>Natural killer (NK) cells play an important role in innate immunity, especially in the response to viral infections, such as hepatitis C virus (HCV). Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that mediate innate immunity. KIRs are also involved in acquired immunity, because some KIRs are expressed on the surface of certain subsets of T cells. In this study, the frequency of KIR genes, <I>HLA-C</I> allotypes, and combinations of KIR genes with their <I>HLA-C</I> ligands were evaluated in two different groups of the Korean population: controls and patients with chronic HCV infection. The study population consisted of 147 Korean patients with chronic HCV infection. The frequency of KIR2DS2 in patients with chronic HCV infection was 9.5% which was significantly lower than 19.5% of the control (<I>P</I> < 0.01). However, there were no significant differences in the frequency of other KIR genes, <I>HLA-C</I> allotypes or different combinations of KIR genes with their <I>HLA-C</I> ligands. This study can contribute to the further prospective study with a larger scale, suggesting the assumption that <I>KIR2DS2</I> might aid in HCV clearance by enhancing both the innate and acquired immune responses of people in Korea.</P>
Choi, Sung‐,Min,Park, Jin‐,Woo Wiley Publishers 2018 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A Vol.106 No.12
<P><B>Abstract</B></P><P>This study investigated the effects of surface modification of clinically available sandblasted/acid‐etched (SLA) titanium oral implants with strontium (Sr)‐containing nanostructures on both early immunoinflammatory macrophage cell functions and osteogenic stem cell functions. The goal was to provide insight for future surface engineering of titanium implants with multifunctional effects, that is, tissue healing capacity at both the nonosteogenic cell centered initial stage and the subsequent osteogenic cell‐governed later stage‐osseointegration process. The Sr‐containing nanostructure was prepared in on the SLA‐type implant surface by wet chemical treatment. The results showed that Sr modification is favorable for early macrophage cell functions and increases osteogenic capacity of the SLA surface. Surface Sr modification notably upregulated regenerative macrophage phenotype expression and anti‐inflammatory cytokine IL10 production while suppressing inflammatory cytokine TNFα. Sr incorporation enhanced certain early cellular events of ST2 stem cells such as early cellular spreading and critical integrin gene expression, which in turn notably increased osteogenic differentiation (osteogenesis‐related phenotype gene expression and osteocalcin production) when combined with the microstructured SLA implant surface. Surface modification of SLA‐type implants with Sr‐containing nanostructures demonstrated the ability to favorably influence early immunoinflammatory macrophage cell functions and the functionality of osteogenesis cells, resulting in an enhanced osseointegration outcome. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3009–3020, 2018.</P>