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Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
Choi, Bo-Gil,Kim, Ok-Young,Chung, Byung-Ho,Cho, Won-Jea,Cheon, Seung-Hoon,Choi, Sang-Un,Lee, Chong-Ock The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2
Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
Choi, Eun-Ok,Park, Cheol,Shin, Soon Shik,Cho, Eun-Ju,Kim, Byung Woo,Hwang, Jin Ah,Hwang, Hye-Jin,Choi, Yung Hyun D. A. Spandidos 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.1
<P>Zanthoxylum schinifolium is widely used as a food flavoring in east Asia. Although this plant has also been used in traditional oriental medicine for the treatment of the common cold, toothache, stomach ache, diarrhea and jaundice, its anti-obesity activity remains to be elucidated. The present study investigated the effects of ethanol extract from the leaves of Z. schinifolium (EEZS) on adipocyte differentiation, and its underlying mechanism, in 3T3-L1 pre-adipocytes. The results demonstrated that EEZS effectively suppressed intracellular lipid accumulation at non-toxic concentrations, and was associated with the downregulation of several adipocyte-specific transcription factors, including peroxisome proliferation-activity receptor γ (PPARγ), CCAAT/enhancer binding protein (C/EBP)α and C/EBPβ, in a concentration-dependent manner. Furthermore, it was observed that EEZS markedly inactivated the extracellular signal-regulated protein kinase (ERK) and phosphatidylinositide 3-kinase (PI3K)/Akt pathways, which act upstream of PPARγ and C/EBPs in adipogenesis. These results suggested that EEZS inhibited lipid accumulation by downregulating the major transcription factors involved in the pathway of adipogenesis, including PPARγ, C/EBPα and C/EBPβ, via regulation of the ERK and PI3K/Akt signaling pathways in 3T3-L1 adipocyte differentiation. This indicated the potential use of EEZS as an anti-obesity agent.</P>
Accumulation and Toxicity of Germanium in Cucumber under Different Types of Germaniums
Choi, Ik Won,Seo, Dong Cheol,Han, Myung Ja,DeLaune, R. D.,Ok, Yong Sik,Jeon, Weon Tai,Lim, Byung Jin,Cheong, Yong Hwa,Kang, Hang Won,Cho, Ju Sik Taylor Francis 2013 Communications in soil science and plant analysis Vol.44 No.20
Choi, Yu-Ri,Jung, Sung-Chul,Shin, Jinhee,Yoo, So Young,Lee, Ji-Su,Joo, Jaesoon,Lee, Jinho,Hong, Young Bin,Choi, Byung-Ok Korean Society of Medical Genetics and Genomics 2015 대한의학유전학회지 Vol.12 No.1
Purpose: Charcot-Marie-Tooth disease (CMT) is a peripheral neuropathy mainly divided into CMT type 1 (CMT1) and CMT2 according to the phenotype and genotype. Although molecular pathologies for each genetic causative have not been revealed in CMT2, the correlation between cell death and accumulation of misfolded proteins in the endoplasmic reticulum (ER) of Schwann cells is well documented in CMT1. Establishment of in vitro models of ER stress-mediated Schwann cell death might be useful in developing drug-screening systems for the treatment of CMT1. Materials and Methods: To develop high-throughput screening (HTS) systems for CMT1, we generated cell models using transient expression of mutant proteins and chemical induction. Results: Overexpression of wild type and mutant peripheral myelin protein 22 (PMP22) induced ER stress. Similar results were obtained from mutant myelin protein zero (MPZ) proteins. Protein localization revealed that expressed mutant PMP22 and MPZ proteins accumulated in the ER of Schwann cells. Overexpression of wild type and L16P mutant PMP22 also reduced cell viability, implying protein accumulation-mediated ER stress causes cell death. To develop more stable screening systems, we mimicked the ER stress-mediated cell death in Schwann cells using ER stress inducing chemicals. Thapsigargin treatment caused cell death via ER stress in a dose dependent manner, which was measured by expression of ER stress markers. Conclusion: We have developed genetically and chemically induced ER stress models using Schwann cells. Application of these models to HTS systems might facilitate the elucidation of molecular pathology and development of therapeutic options for CMT1.
Mutational analysis of whole mitochondrial DNA in patients with MELAS and MERRF diseases
Choi, Byung-Ok,Hwang, Jung-Hee,Cho, Eun-Min,Jeong, Eun-Hye,Hyun, Young-Se,Jeon, Hyeon-Jeong,Seong, Ki-Min,Cho, Nam-Soo,Chung, Ki-Wha Korean Society for Biochemistry and Molecular Bion 2010 Experimental and molecular medicine Vol.42 No.6
Mitochondrial diseases are clinically and genetically heterogeneous disorders, which make the exact diagnosis and classification difficult. The purpose of this study was to identify pathogenic mtDNA mutations in 61 Korean unrelated families (or isolated patients) with MELAS or MERRF. In particular, the mtDNA sequences were completely determined for 49 patients. From the mutational analysis of mtDNA obtained from blood, 5 confirmed pathogenic mutations were identified in 17 families, and 4 unreported pathogenically suspected mutations were identified in 4 families. The m.3243A>G in the tRNA$^{Leu(UUR)}$ was predominantly observed in 10 MELAS families, and followed by m.8344A>G in the tRNA$^{Lys}$ of 4 MERRF families. Most pathogenic mutations showed heteroplasmy, and the rates were considerably different within the familial members. Patients with a higher rate of mutations showed a tendency of having more severe clinical phenotypes, but not in all cases. This study will be helpful for the molecular diagnosis of mitochondrial diseases, as well as establishment of mtDNA database in Koreans.
Choi, Jung-Hyun,Jung, Byung-Ha,Kang, Ok-Hwa,Choi, Hyuk Joon,Park, Pil Sang,Cho, Sun Hee,Kim, Youn-Chul,Sohn, Dong Hwan,Park, Hyun,Lee, John Hwa,Kwon, Dong-Yeul Pharmaceutical Society of Japan 2006 Biological & pharmaceutical bulletin Vol.29 No.5
<P>The anti-inflammatory and anti-nociceptive effects and sedative activities of the ethyl acetate fraction of <I>Cynanchum paniculatum</I> (EACP) were evaluated in mice and rats by acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, cotton pellet-induced granuloma formation, formalin-induced licking time, acetic acid-induced writhing response, and pentobarbital-induced sleeping time. EACP at a dose of 40 mg/kg significantly exhibited anti-inflammatory activities on acetic acid-induced vascular permeability, arachidonic acid-induced paw edema, and the late phase of formalin-induced licking time. Moreover, it showed anti-nociceptive effects on acetic acid-induced writhing responses and significant sedative effects on pentobarbital-induced sleeping time. The results demonstrated that the anti-nociceptive effects are apparently related to the sedative effects of EACP. These results support the use of <I>Cynanchum paniculatum</I> in relieving inflammatory pain.</P>
Calcific Amyloidoma of Tibialis Anterior Muscle
Byung-Ki Cho(조병기),Yong-Min Kim(김용민),Dong-Soo Kim(김동수),Eui-Sung Choi(최의성),Hyun-Chul Shon(손현철),Kyung-Jin Park(박경진),Hu-Shan Cui(최호산),Seok-Won Kim(김석원),Ok-Jun Lee(이옥준) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.3
연부조직에 발생하는 단발성 아밀로이드종은 매우 드물다. 저자들은 경골 근위부 골절 후 20여년 뒤에 전경골근에서 발생한 염증을 동반한 석회화성 아밀로이드종 1예를 경험하였으며, 종양 제거술 후 재발없이 만족스런 결과를 얻을 수 있었다. 아밀로이드종은 매우 드물기도 하고 골수염이나 골종양과 구분이 어려웠던 경우이므로 문헌고찰과 함께 증례보고를 하는 바이다. Calcific amyloidoma of the soft tissue is quite rare and it is difficult to make a differential diagnosis from other lesions such as osteomyelitis or bone tumor. We encountered a case of a calcified amyloidoma found in the anterior tibial muscle that occurred more than 20 years after a proximal tibial fracture adjacent to the origin of the muscle. The features of the lesion resembled osteomyelitis. Satisfactory result was obtained by a thorough mass excision. We report this case with review of the relevant literature.