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Fractionated Stereotactic Radiotherapy for Metastatic Brain Tumor in Non-Small Cell Lung Cancer
Cho, Moon-June,Kim, Ki-Hwan,Kim, Jun-Sang,Kim, Seon-Hwan,Song, Shi-Hun,Song, Chang-Joon,Lim, Seung-Pyung,Kim, Sun-Young,Kim, Jae-Sung 충남대학교 암공동연구소 2003 암공동연구소 업적집 Vol.3 No.
Purpose: To evaluate the results of treatment with fractionated stereotactic radiotherapy for metastatic brain tumors in non-small cell lung cancer. Materials and Methods: Between August 1997 and August 2001, 17 patients, with metastatic brain tumors in non-small cell lung cancer (26 lesions), completed frameless fractionated stereotactic radiotherapy. All patients received a 30~36 Gy/10~20 fx external beam irradiation to the whole brain. Twelve received fractionated stereotactic radiotherapy for a single lesion, 3 for 2 lesions and 1 each for 3 and 5 lesions. The median tumor volume was 1.7 cc (0.3~55.2 cc). The fractionation schedule for the fractionated stereotactic radiotherapy was 21 Gy/3 fx in 8 lesions, 25 Gy/5 fx in 7, 18 Gy/1 fx in 6, 30 Gy/5 fx in 4 and 15 Gy/5 fx in 1. Multiple-arc, and 3D conformal, fractionated stereotactic radiotherapy, were delivered to 24 and 2 lesions, respectively. Follow-up was possible in all patients. Results: Nine out of 13 patients with follow-up radiological evaluations achieved a complete response (CR). The overall median survival, and 1 and 2 year survival rates were 20 months, and 64 and 28%, respectively. The median survival, and the 1 and 2 year survival rate of CR group were 20 months, and 73 and 22%, respectively. No patient has experienced any acute side reactions or late complications from the fractionated stereotactic radiotherapy. Conclusion: Although the number of patients treated with fractionated stereotactic radiotherapy was small, and follow-up period short, this study suggests that external beam irradiation to the whole brain, with 30 Gy/10 fx followed by fractionated stereotactic radiotherapy, could be a good treatment option for patients with metastatic brain tumors in non-small cell lung cancer. (J Lung Cancer 2002;1(1):48-54)
Foreign Currency Noncore Bank Liabilities and Macroprudential Levy in Korea
( Sung Bin Cho ),( Joon Ho Hahm ) 한국국제경제학회 2014 한국국제경제학회 동계학술대회 Vol.2014 No.1
Recent research indicates that noncore liabilities of banks are highly procyclical and constitute an important transmission channel of global liquidity shocks to open emerging economies. Using the bank level data in Korea, we examine empirical properties of foreign currency noncore bank liabilities, and assess policy effectiveness of the macroprudential levy introduced in post-crisis Korea. Our panel regression and VAR analyses indicate that the foreign currency noncore bank liability ratio yields significant information on the vulnerability of banks, and the macroprudential levy has exerted non-trivial impacts on the noncore funding of banks leading to the mitigation of foreign currency liquidity risks of Korean banks. The findings of the present study strengthen the rationale for using appropriate macroprudential policies as a guard against financial vulnerability in open emerging economies.
Properties of Indium Doped Zinc Oxide Thin Films Deposited by RF Magnetron Sputtering
Joon Ho Bang,Se Hun Park,Sang Hyun Cho,Pung Keun Song 한국표면공학회 2010 한국표면공학회지 Vol.43 No.4
Indium doped zinc oxide films (ZIO) were deposited on non-alkali glass substrates by radio frequency (RF) magnetron sputtering at room temperature. The structural, electrical and optical properties of the ZIO films were investigated as a function of their In₂O₃ content (3.33-15.22 wt%). The ZIO films deposited with an In₂O₃ content of 9.54 wt% showed a relatively low resistivity of 9.13×10<SUP>?4</SUP> Ω㎝ and a highly c-axis preferred orientation. The grain size and FWHM were mainly affected by the In₂O₃ content. The crystallinity and resistivity were enhanced with increasing grain size. The average transmittance of the ZIO films was over 85% in the visible region and their band gap varied from 3.22 to 3.66 eV depending on their doping ratio.
Epigenomics: Novel Aspect of Genomic Regulation
Cho, Hwan-Sung,Park, Jong-Ho,Kim, Young-Joon Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.2
An International Symposium on Epigenomics took place at Yonsei University, Korea in December, 2006. The meeting brought to light new aspects of genome regulation by DNA and protein modification.
Cho, Jung Sun,Jeong, Myung Ho,Sim, Doo Sun,Hong, Young Joon,Lim, Kyung Seob,Kim, Jung Ha,Kim, Hyoung Doo,Baek, Ju Yeal,Yoon, Hee Jeoung,Her, Sung-Ho,Jin, Seung Won,Kim, Ju Han,Ahn, Youngkeun,Cho, Jeon The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.5
<P>The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.3:1) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337±227 vs. 443±366 cells, <I>P</I>=0.292), but neointima area was significantly smaller (1.00±0.49 mm<SUP>2</SUP> vs. 1.69±0.98 mm<SUP>2</SUP>, <I>P</I>=0.021) and percent area stenosis was significantly lower (23.3±10% vs. 39±19%, <I>P</I>=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99±0.79 vs. 1.81±0.88, <I>P</I>=0.49), endothelial score (1.75±0.66 vs. 1.80±0.59, <I>P</I>=0.79), and the percent of endothelium covered lumen (43±21% vs. 45±21%, <I>P</I>=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model.</P>
Growth of BaTiO3-PVDF Composite Thick Films by Using Aerosol Deposition
Sung Hwan Cho,Young Joon Yoon 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.2
Barium titanate (BaTiO3)-polyvinylidene fluoride (PVDF) composite thick films were grown by using aerosol deposition at room temperature with BaTiO3 and PVDF powders. To produce a uniform composition in ceramic and polymer composite films, which show a substantial difference in specific gravity, we used PVDF-coated BaTiO3 powders as the starting materials. An examination of the microstructure confirmed that the BaTiO3 were well distributed in the PVDF matrix in the form of a 0 − 3 compound. The crystallite size in the BaTiO3-PVDF composite thick films was 5 50 times higher than that in pure BaTiO3 thick films. PVDF plays a role in suppressing the fragmentation of BaTiO3 powder during the aerosol deposition process and in controlling the relative permittivity.
Cho, Chung-Hyun,Sung, Hoon-Ki,Kim, Kyung-Tae,Cheon, Hyae Gyeong,Oh, Goo Taeg,Hong, Hyo Jeong,Yoo, Ook-Joon,Koh, Gou Young National Academy of Sciences 2006 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.103 No.13
<P>Microvascular dysfunction is a major cause of impaired wound healing seen in diabetic patients. Therefore, reestablishment of structural and functional microvasculature could be beneficial to promote wound healing in these patients. Angiopoietin-1 (Ang1) is a specific growth factor functioning to generate a stable and functional vasculature through the Tie2 and Tie1 receptors. Here we determined the effectiveness of cartilage oligomeric matrix protein (COMP)-Ang1, a soluble, stable, and potent form of Ang1, on promotion of healing in cutaneous wounds of diabetic mice. An excisional full-thickness wound was made in the dorsal side of the tail of diabetic (db/db) mice, and mice were then treated systemically with adenovirus (Ade) encoding COMP-Ang1 or with control virus encoding beta-gal (Ade-beta-gal) or treated topically with recombinant COMP-Ang1 protein or BSA. Time course observations revealed that mice treated with Ade-COMP-Ang1 or COMP-Ang1 protein showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis and lymphangiogenesis, and higher blood flow in the wound region compared with mice treated with control virus or BSA. COMP-Ang1 promotion of wound closure and angiogenesis was not dependent on endothelial nitric oxide synthase or inducible nitric oxide synthase alone. Taken together, these findings indicate that COMP-Ang1 can promote wound healing in diabetes through enhanced angiogenesis, lymphangiogenesis, and blood flow.</P>