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RISS 인기검색어
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- 저자 : Ching-Tien Tseng (검색결과 2 건)
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Kai Hsia,Tien-Shiang Wang,Chin-Su Liu,Chih-Kuan Su,Chien-Chin Chen,Chang-Ching Yeh,Hsinyu Lee,Chao-Ling Yao,Tsung-Yu Tseng,Shih-Hwa Chiou,Hsu Ma,Chih-Hsun Lin,Jen-Her Lu 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.3
Decellularized human umbilical arteries (dHUA) is an off-the-shelf graft that can potentially serve as vascular scaffolds in tissue engineering of small-diameter vascular grafts. This research aimed to investigate that dHUA could exhibit adequate endothelialization for a long term in xenogenic transplantation. 13 dHUAs were implanted in rat abdominal aortas up to 90 days. Rats were divided into three groups in terms of survival period: Group 1, one to seven days (n = 6); Group 2, 14 to 30 days (n = 4) and Group 3, 90 days (n = 3). The explants were analyzed by histological, immunohistochemistry and magnetic resonance angiography (MRA) examination. Allograft implantation of 12 decellularized rat abdominal aortas` were processed the same way as the rat in order to make a comparison for survival rates (Group 1, n = 5; Group 2, n = 4; Group 3, n = 3). The results demonstrated that the survival rates of xenograft and allograft implantation were estimated to be 59.2% vs. 58.3% in Group 1, 50.7% vs. 58.3% in Group 2 and 3. Grafts harvested from Group 2 were showed CD31, endothelial nitric oxide synthase expression at intima, and α-smooth muscle actin, CD45, CD68 and CD168 expression at the tunica externa. A layer structure with obvious endothelialization and fiber regeneration/orientation could be inspected from the explants of Group 3. MRA demonstrated the patency of dHUA on day 30 and 90. In conclusion, more than 50% dHUA maintained patency in the xenogenic model till 90 days after surgery. A mature vessel-like functional structure with intact endothelial layer was observed then. This warrants further study in the reinforcement of decellularized vascular scaffolds.
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Elevated plasma YKL-40 level is found in the dogs with cancer and is related to poor prognosis
Kai-Chung Cheng,Jih-Jong Lee,Shang-Lin Wang,Chun-Yu Lin,Ching-Tien Tseng,Chen-Si Lin,Albert Taiching Liao 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.5
YKL-40, a secreted glycoprotein, may serve as an autoantigen, which mediates multipleinflammatory diseases and cancers. A high YKL-40 serum level is correlated with metastasisand poor survival in a variety of human cancers. However, the role of YKL-40 in dogs is stillunder evaluation. Herein, we examined the associations between plasma YKL-40 level andYKL-40 autoantibody (YAA) titers with malignancy and prognosis in canine cancer. Plasmalevels of YKL-40 in healthy dogs (n = 20) and in dogs (n = 82) with cancer were evaluatedusing enzyme-linked immunosorbent assay. Our results indicated that plasma YKL-40 levelswere significantly higher (p < 0.01) in dogs with cancer than in healthy dogs. A significantdecrease in the YAA titers was detected in the dogs with cancer when compared with thoseof the healthy dogs (p < 0.05), although the change was not correlated with the YKL-40levels. Among the dogs with cancer, plasma YKL-40 levels in the dogs that later relapsed orhad metastasis were significantly higher than in the dogs with no signs of relapse (p < 0.01)or metastasis (p <0.05). The relapse and metastasis rates were significantly higher in thehigh YKL-40 group (> 180 pg/mL) than in the low YKL-40 group (< 180 pg/mL). The resultsimply that plasma YKL-40 levels might have the potential to be developed as a marker ofmalignancy progression and prognosis in canine cancers.
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