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      • KCI등재후보

        Seismic behavior of post-tensioned precast reinforced concrete beam-to-column connections

        Chin-Tung Cheng 사단법인 한국계산역학회 2008 Computers and Concrete, An International Journal Vol.5 No.6

        In this research, the self-centering effect in precast and prestressed reinforced concrete structures was investigated experimentally. The reinforced concrete beams and columns were precast and connected by post-tensioning tendons passing through the center of the beams as well as the panel zone of the connections. Three beam-to-interior-column connections were constructed to investigate parameters such as beam to column interfaces (steel on steel or plastic on plastic), energy dissipating devices (unbonded buckling restrained steel bars or steel angles) and the spacing of hoops in the panel zone. In addition to the self-centering effect, the shear strength in the panel zone of interior column connections was experimentally and theoretically evaluated, since the panel zone designed by current code provisions may not be conservative enough to resist the panel shear increased by the post-tensioning force.

      • KCI등재

        Seismic performance of a rocking bridge pier substructure with frictional hinge dampers

        Chin-Tung Cheng,Fu-Lin Chen 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.4

        The rocking pier system (RPS) allows the columns to rock on beam or foundation surfacesduring the attacks of a strong earthquake. Literatures have proved that seismic energy dissipated by the RPSthrough the column impact is limited. To enhance the energy dissipation capacity of a RPS bridgesubstructure, frictional hinge dampers (FHDs) were installed and evaluated by shaking table tests. Thesupplemental FHDs consist of two brass plates sandwiched by three steel plates. The strategy ofself-centering design is to isolate the seismic energy by RPS at the columns and then dissipate the energy byFHDs at the bridge deck. Component tests of FHD were first conducted to verify the friction coefficient anddynamic characteristic of the FHDs. In total, 32 shaking table tests were conducted to investigate parameterssuch as wave forms of the earthquake (El Centro 1940 and Kobe 1995) and normal forces applied on thefriction dampers. An analytical model was also proposed to compare with the tested damping of the bridgesub-structure with or without FHDs.

      • SCIESCOPUS

        Seismic performance of a rocking bridge pier substructure with frictional hinge dampers

        Cheng, Chin-Tung,Chen, Fu-Lin Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.14 No.4

        The rocking pier system (RPS) allows the columns to rock on beam or foundation surfaces during the attacks of a strong earthquake. Literatures have proved that seismic energy dissipated by the RPS through the column impact is limited. To enhance the energy dissipation capacity of a RPS bridge substructure, frictional hinge dampers (FHDs) were installed and evaluated by shaking table tests. The supplemental FHDs consist of two brass plates sandwiched by three steel plates. The strategy of self-centering design is to isolate the seismic energy by RPS at the columns and then dissipate the energy by FHDs at the bridge deck. Component tests of FHD were first conducted to verify the friction coefficient and dynamic characteristic of the FHDs. In total, 32 shaking table tests were conducted to investigate parameters such as wave forms of the earthquake (El Centro 1940 and Kobe 1995) and normal forces applied on the friction dampers. An analytical model was also proposed to compare with the tested damping of the bridge sub-structure with or without FHDs.

      • Histopathological Evidence for the Existence of Primary Liver Progenitor Cell Cancer: Insight from Cancer Stem Cell Pathobiology

        ( Cheng-maw Ho ),( Shu-li Ho ),( Chia-tung Shun ),( Po-huang Lee ),( Ya-hui Chen ),( Chin-sung Chien ),( Hui-ling Chen ),( Rey-heng Hu ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: Primary liver progenitor cell cancer is a rare disease entity without definite evidence and characterization. Current nomenclature of primary liver cancer with prominent progenitor features is not comprehensive. This study was aimed to investigate the existence of this kind of primary liver cancer and characterize it immunohistopathologically based on the emerging understanding of cancer stem cell pathobiology. Methods: Surgical specimens from primary liver cancer which posed diagnostic difficulty fitting within current WHO classification of combined hepatocellular-cholangiocellular carcinoma with stem-cell features according to the growth morphology and its suggested immunohistochemical features, were stained with antibodies against well-defined markers of progenitor cells, stemness, and differentiation toward hepatocytes or cholangiocytes. Comparative interpretation of images was processed considering the histological morphology and characteristic markers. Results: The primary liver cancer consisted of CD24+ cancer progenitor cells and CD90+ mesenchymal stromal cells, which were intimately mixed. CD24+ cancer cells demonstrated bi-directional trends of differentiation: bile ductule transformation (cytokeratin 19+, epithelial cell adhesion molecule [EpCAM]+, neural cell adhesion molecule [NCAM]+, CD133+, and delta-like 1 homolog [DLK1]+); and trabecular or nested cell clusters toward hepatic lineage (hepatocyte nuclear factor-4 alpha [HNF-4α]+, Hep Par1+ and negative for CK19, EpCAM, CD133, and DLK1). Moderate lymphocyte (mostly CD4+ and CD8+ T cells) infiltrated in the CD90+ cancer- associated stroma. Conclusions: We provided the corroboration that liver progenitor cells can form primary liver cancer, not just presented as few side population of cancer stem cells. Its existence might pose significance for future stem cell therapeutic intervention targeting liver diseases, albeit the disease is rare.

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