급성 조증에서 기분안정제와 리스페리돈의 병합 투여 효과 : 다기관 개방연구

김광수,배치운,윤진상,김영훈,이양현,지익성,이철,송혜경,최성구,박원명 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Ohjective : The primary purpose of this study was a replication of the effectiveness and tolerability of rispehdone in the treatment of patients with acute mania in very larger cohon in naturalistic treatment setting to extend the data on the effect and tolerability of risperidone in the treatment of patients with acute mania to Asian population. Methods : A total of 909 patients with DSM-TV criteria of bipolar disorder current manic and hypomanic episode, entered this large, open, multicentre study. The Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI) and Simpson-Angus Rating Scale (SARS) were measured at baseline and weeks 1, 3 and 6, for the assessment of effectiveness and extra-pyramidal symptom (EPS). Results : This study showed statistically significant reduction of scores on the YMRS and CGI-s (mean change=-23.5±11.8, p<0.0001 ; mean change=-2.7±1.5, p<0.0001, respectively) from the baseline to the endpoint (week 6). Number of patients with 50% reduction or more in the YMRS and CGI-s scores was 693 (77.8%) and 630 (70.7%) at endpoint, respec-tively. There were no statistically significant increments of scores on SARS. Risperidone was generally well tolerated. Conclusion : The present larger open study demonstrates that hsperidone add-on therapy is effective and tolerable in treat-ment of bipolar disorder, replicating results in various controlled and uncontrolled studies from Western countries.

-G308A Tumor Necrosis Factor-α 유전자 다형성과 주요 우울장애의 연합연구

배치운,오해정,채정호,박원명,전태연,한훈,김광수 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : The present study was to examine possible association between the - G308A tumor necrosis factor (TNF)-α gene polymorphism and major depressive disorder (MDD) in Korean. Methods : 108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Results : Genotype and allele distributions in patients with MDD (p=0.02, P=0.01, respectively), were significantly different from those of the controls. Conclusion : The present study suggests that the -G308A TNF-α gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.

주요 우울장애에서 Cytotoxic T Lynphocyte Antigen(CTLA-4) 유전자의 다형성

전태연,배치운,김병균,채정호,박원명,김광수,유태열,한훈 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 세포의 면역 기능 조절에 관여하는 CTLA-4의 유전자 다형성을 분석하여 주요 우울장애와의 면역 유전학적 관련성을 알아보고자 하였다. 방 법 : DSM-Ⅳ진단 기준에 따라 주요 우울장애로 진단된 환자 77명을 선정하였으며 가톨릭대학교 의과대학 조혈모세포은행에서 보유하고 있는 149명의 정상 한국인 자료를 대조군으로 사용하였다. 전혈에서 DNA를 추출하였으며 중합효소반응으로 CTLA-4유전자 exon 1 부위를 증폭한 후 SSCP방법으로 유전?? 형별 분석하였다. 결 과 : 대조군과 주요 우울장애 환자군 사이의 CTLA-4 유전자형과 대립유전자의 발현 빈도를 비교시 유의한 차이가 없었다. 결 론 : 본 연구 결과 exon 1 CTLA-4 유전자형 및 대립유전자의 발현빈도는 주요 우울장애 환자군과 정상 대조군 사이에 차이가 없어, exon 1 영역은 후보 유전자로서의 가능성이 없었다. 향후 연구에서는 다양한 변인들에 따라 대상군을 임상적으로 동질성을 지닌 집단으로 세분하여 조사대상 유전자와의 관련성에 대한 연구가 이루어져야 하겠다. Objectives : This study was carried out to explore the relationship between major depressive disorder and CTLA-4 which is related to the immunologic function such as T cell regulation. Methods : Among the korean patients diagnosed as major depressive disorder according to DSM-Ⅳ, 77 patients without neurological illness, hormonal disorder, or comorbid mental illness were selected. The stored data of 149 normal Koreans from the Catholic Hemopoietic Stem Cell Bank of Korea, were used as a normal control group. The data of Korean control group were compared with those of the studies of different ethnics. DNA was extracted from whole blood and the exon I region of CTLA-4 gene was amplified by polymerase chain reaction. Gene typing was performed by using SSCP and then, the results were assessed. Results : There were no significant differences in genotype frquencies of CTLA-4*G/G, CTLA-4*G/A, and CTLA-4*A/A between the patients with major depressive disorder and the control group in Korean population(48.1% vs 46.3%, 41.6% vs 39.6%, 10.3% vs 14.1%, respectively).There were no significant differences in allelic frequencies of CTLA-4*G and CTLA-4*A between the patients with major depressive disorder and the control group in Korean population(68.8% vs 66.1%, 31.2% vs 33.9%, respectively). Conclusion : Considering negative result for the association of the exon I polymorphism of CTLA-4 gene with major depressive disorder in this study, the exon I polymorphism does not appear to be possible candidate gene for major depressive disorder. Moreover, further systematic researches including diverse clinical variables would required.

Landslide Stability Analysis and Prediction Modeling with Landslide Occurrence on KOMPSAT EOC Imagery

Kwang Hoon Chi,Ki Won Lee,No Wook Park 大韓遠隔探査學會 2002 大韓遠隔探査學會誌 Vol.18 No.1

Landslide prediction modeling has been regarded as one of the important environmental applications in GIS. While, landslide stability in a certain area as collateral process for prediction modeling can be characterized by DEM-based hydrological features such as flow-direction, flow-accumulation, flow-length, wetness index, and so forth. In this study, Slope-Area plot methodology followed by stability index mapping with these hydrological variables is firstly performed for stability analysis with actual landslide occurrences at Boeun area, Korea, and then landslide prediction modeling based on likelihood ratio model for landslide potential mapping is carried out; in addition, KOMPSAT EOC imagery is used to detect the locations and scarped scale of landslide occurrences. These two tasks are independently processed for preparation of unbiased criteria, and then results of those are qualitatively compared. As results of this case study, land stability analysis based on DEM-based hydrological variables directly reflects terrain characteristics; however, the results in the form of land stability map by landslide prediction model are not fully matched with those of hydrologic landslide analysis due to the heuristic scheme based on location of existed landslide occurrences within prediction approach, especially zones of not-investigated occurrences. Therefore, it is expected that the results on the space-robustness of landslide prediction models in conjunction with DEM-based landslide stability analysis can be effectively utilized to search out unrevealed or hidden landslide occurrences.

Development of Image Processing Software for Satellite Data

Chi, Kwang Hoon,Suh, Jae Young,Han, Jong Kyu 대한원격탐사학회 1998 International Symposium on Remote Sensing Vol.14 No.1

Recently, the improvement of on-board satellite sensors covering hyperspectral image sensors, high spatial resolution sensors provide data on earth in diverse aspect. The application field relating remotely sensed data also varies depending on what type of job one wants. The various resolution of sensors from low to extremely high is also available on the market with a user defined specific location. The expense to purchase remote sensed data is going down compare to the cost it need past few years ago in terms of research or private use. Now, the satellite remote sensed data is used on the field of forecasting, forestry, agriculture, urban reconstruction, geology, or other research field in order to extract meaningful information by applying special techniques of image processing. There are many image processing packages available worldwide and one common aspect is that they are expensive. There need to be a advanced satellite data processing package for people who can not afford commercial packages to apply special remote sensing techniques on their data and produce valued-added product. The study was carried out with the purpose of developing a special satellite data processing package which covers almost every satellite produced data with normal image processing functions and also special functions needed on specific research field wth friendly graphical user interface (GUI). And for the people with any background of remote sensing with wndows platform.

Development of the Geo-Information Data Base Management System

Chi, Kwang Hoon,Suh, Jae Young,Han, Jong Kyu 대한원격탐사학회 1997 International Symposium on Remote Sensing Vol.13 No.1

KIGAM Geo-Information System(KGIS) is an information system that is designed to work with data referenced by spatial or geographic coordinates. The system is capable of handling spatial geoscience data such as geologic map, geochemistry map, geophysical map, ore deposits, profile map and other geoscience information. The spatial geoscience data used in the field of Geographic Information System(GIS) and Remote Sensing(RS) consists of may different formats either in vector or raster in more than hundred of layers representing their unique spatial data. The need to integrate large amount and different formats of spatial data together in one whole database file and allows the user to manipulate, overlay, analysis and create meaningful information came to be a big issue.

A Study on the Extraction of Groundwater Potential Area Utilizing the Remotely Sensed Data

Kwang Hoon Chi 大韓遠隔探査學會 1994 大韓遠隔探査學會誌 Vol.10 No.2

The study is aimed at the extraction of the groundwater potential areas utilizing the remotely sensed data from satellites. The results of the study are summarized as follows. Analyses of the existing operational wells for groundwater supply indicate that 81% of them are related with lineaments and 51% of them are located at the intersections of lineaments. Thus the features of lineaments are considered to be one of the most important parameters to extract a high potential area of groundwater. Taking into acount features of lineaments, high potential points were extracted from Landsat TM data based on the theory developed in this research, then verifications were made through actual drilling. The result of verification indicates that 9 points produces more 200 cubic meter/day which is the amount required from economical point of view for an operational use. Since the actual boring was not made on the recommended points for 4 points due to the difficulty of access to the exact points and of the approval for boring, they did not yield enough output. The result might have been improved if the exact points were bored and if the boring had been made deeper, since the maximum depth of boring was limited to 62 meters.

Land Cover Change Detection using Principal Component Analysis and Fuzzy Set Operation

Chi, Kwang Hoon,Park, Sung Mi,Lee, Ki Won 대한원격탐사학회 1996 International Symposium on Remote Sensing Vol.12 No.1

Change detection problems using remotely sensed data have been studied with the basis of various techniques from analysis of simple difference images to more complex statistical methodology. The goal of this study is to develop general scheme for land cover change detection: adaptive gray scale mapping, generation of Principal Component Analysis(PCA) - based difference image, and fuzzy set operation. Consequently, several tasks related to change detection such as registration noise reduction problems, changed information extraction, and image integration problems are respectively resolved as subsequent steps, in the case of handling multisensor and multitemporal imagery data. As for real application, multitemporal Lai dsat MSS/TM imageries of Hanam city, nearby Seoul, were utilized for the detection project of rural-urban changed information. Meanwhile, additional GIS functions were effectively utilized to obtain quantitative from-to information extracted from the imagery. Conclusively, the algorithms/steps used in this study can he regarded as significant methodologies for land cover change detection from satellite imageries.

A Study of Geological Structure Analysis Using Remotely Sensed Data : Euijungbu-Dongducheon Area in Korea

Chi, Kwang Hoon,Lee, Hong Jin,Park, Maeng Eon 대한원격탐사학회 1997 International Symposium on Remote Sensing Vol.13 No.1

The purpose of this study is to develope the analysis thechnique to use Radarsat SAR for the geological structure and lineament interpretation. The study was carried out in Euijungbu-Dongducheon area where grey biotite granite, pink biotite granite, gneiss complex and alluvium are distributed. Integration image of the SAR and other remotely sensed data such as Landsat TM and SPOT using principal component transformed technique are suitable to discriminate a lithological boundaries. And the Sobel directional filter for SAR data is suitable method for the lineament analysis. There are two prevailing direction in the orientation of lineaments, i.e. one is N20°∼ 30° E while the other is form North to South directions. These techniques are very useful for the analysis of geological structure and lineament.

EVALUATION ON THE SPACE-ROBUSTNESS OF GIS-BASED LANDSLIDE PREDICTION MODELS

Chi, Kwang Hoon,Park, No Wook 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1

The mathematical models have been developed and applied to landslide hazard mapping using geographic information systems. Emphasis has been initially placed on the predictive models for which a unified and general framework has been proposed. Assuming that the information in the database is sufficiently representative of the typical conditions in which mass movements originated in space and in time, the problem then, is to confirm the validity of the results of some models over other ones, or of particular experiments that seem to use more significant data. In this contribution, we discuss the analytical strategy on the stability of landslide prediction models, so that the prediction results can provide meaningful interpretation with respect to the future landslides. For testing on the space-robustness of landslide prediction models, we exemplify whether and to what extent a prediction can be extended, in space, to neighboring areas with similar geomorphology or geology using the validation and stability analysis of the model. A case study from the Boeun area in Korea was used to illustrate the methodologies.