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여재 특성에 따른 생물막여과 공법의 처리특성에 관한 연구
강용태,양희천,송근관,권혁원 동아대학교 건설기술연구소 1999 硏究報告 Vol.23 No.2
In the biofilteration process, the removal of turbidity, color, KMnO₄consumpion, NH₄^(+)-N and UV254 reached 98%, 95%, 70%, 85%, 79% respectively. The stable removal efficiency was obtained by the direct filteration after coagulant dosage, though the influent was muddy and highly polluted. The exhausted GAC was used as the media of biofilter, which obtained stable removal efficiency compared with the other medias such as GAC, ZEOCARBON. Effluent of sorptived THMs was not found after 45 days during filter run time. And the case of dual media filteration was prior to single media filteration in the headloss development and quality of effluent. In the case of the ozone dosage rate was determined the color of biofilteration in the AAWTS system. 1㎎/L ozone dosage was proper when the color was below 8 unit.
Cheon, Jae Hee,Kim, Eun Soo,Shin, Sung Jae,Kim, Tae Il,Lee, Kang Moon,Kim, Sang Woo,Kim, Joo Sung,Kim, You Sun,Choi, Chang Hwan,Ye, Byong Duk,Yang, Suk-Kyun,Choi, Eun Hee,Kim, Won Ho American College of Gastroenterology 2009 The American journal of gastroenterology Vol.104 No.10
<P>OBJECTIVES: It is difficult to diagnose intestinal Behçet's disease (BD) due to various extraintestinal manifestations emerging at different time points in the disease course and a lack of reliable diagnostic criteria. We conducted this study to develop and validate novel diagnostic criteria for intestinal BD. METHODS: Experts from three universities generated the preliminary diagnostic criteria for intestinal BD, and a consensus was reached using a modified Delphi method with 13 gastroenterologists participating. To validate the criteria, we recruited 12,850 consecutive patients who underwent colonoscopic examinations between January 2000 and December 2006 at Severance Hospital, Yonsei University, Seoul, Korea. RESULTS: The novel diagnostic criteria were developed on the basis of two aspects: colonoscopic findings and extraintestinal manifestations. Of the 12,850 patients, 280 with ileocolonic ulcers were enrolled for validation. At the time of initial colonoscopic examinations, patients were categorized for BD status into 4 groups: definite (84 patients), probable (67), suspected (15), and nondiagnostic (114). At the end of the follow-up period (mean, 50.9+/-25.7 months), intestinal BD was confirmed in 145 patients (51.8%)-84 (100%) from the definite group, 49 (73.1%) from the probable group, 10 (66.7%) from the suspected group, and 2 (1.8%) from the nondiagnostic group. The overall sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the diagnosis probability of these criteria were 98.6, 83.0, 86.1, 98.2, and 91.1%, respectively. CONCLUSIONS: These newly proposed, simple criteria might be useful in diagnosing intestinal BD, especially in patients with ileocolonic ulcers who do not fully satisfy the diagnostic criteria of systemic BD.</P>
Mutations in gyrA and gyrB among Drug Resistant Mycobacterium Tuberculosis in Korea
( Hee Joo Lee ),( Hwi-Jun Kim ),( Ryeun Heo ),( Cheon-Tae Kim ),( Hee-Jin Kim ),( Jeong-hui Gwon ),( Gicheon Bae ),( Sumi Kang ),( Soul-hee Kim ),( Seungmo Kim ),( Eunseon Kim ),( Arim Song ),( Dea-Se 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Purpose In 2020 KATRD, we analyzed 65 isolates to see how gyrA and gyrB are associated with 7H9 broth microdilution method (BMD) and Lowenstein-Jensen (L-J) drug susceptibility test (DST) because fluoroquinolones (FLQ) have been recognized as important anti-TB agents. In this study, the aim is to evaluate the correlation between gyrA and gyrB mutations and resistance to FLQ with BMD and L-J DST as a follow up of the previous study. Method Since 2020, we have analyzed 304 INH or RIF mono resistant cases by molecular DST using sequencing for gyrA and gyrB genes of FLQ. MICs were measured by BMD for moxifloxacin (MFX, 0.0625~8.0 μg/mL) and levofloxacin (LFX, 0.0625~8.0 μg/ mL). In L-J DST, concentration of MFX was 1.0 μg/mL, 2.0 μg/mL and LFX was 2.0 μg/mL. Results In gyrA and gyrB sequencing, 270 strains (88.81%) were wild type (WT), 34 strains (11.18%) were mutant type (MT). Among 29 gyrA MT strains, 13 isolates (44.82%) had mutation at D94G, 7 isolates (24.14%) at A90V and 5 isolates (17.24%) at D94A. Among 5 gyrB MT strains, 2 isolates (40%) had D500N mutation. In L-J DST, 100% of gyrA MT strains were resistant to MFX. On the other hand gyrB MT strains, 60% to MFX and 40% to LFX were resistant. In BMD, 93.10% of gyrA MT strains ranged 0.5 ~ 4.0 μg/mL and 60% of gyrB MT strains ranged 0.5 ~ 4.0 μg/mL to MFX. Meanwhile 96.55% of gyrA MT strains ranged 1.0 ~ 8.0 μg/mL and 80% of gyrB MT strains ranged 1.0 ~ 8.0 μg/mL to LFX. Conclusions Most of the mutant isolates had mutations in gyrA and most of mutant type (38.23%) was gyrA_D94G (GAC/GGC). In this study we observed gyrA genes were associated with higher MICs based on 7H9 and L-J DST than gyrB genes. # No.2021R1F1A1061358
Involvement of heme oxygenase-1 in Korean colon cancer.
Kang, Kyoung Ah,Maeng, Young Hee,Zhang, Rui,Yang, Young Ro,Piao, Mei Jing,Kim, Ki Cheon,Kim, Gi Young,Kim, Young Ree,Koh, Young Sang,Kang, Hee Kyoung,Hyun, Chang Lim,Chang, Weon Young,Hyun, Jin Won Saikon Pub. Co 2012 TUMOR BIOLOGY Vol.33 No.4
<P>Heme oxygenase-1 (HO-1) catabolizes heme into carbon monoxide, biliverdin, and free iron which mediate its protective effect against oxidative stress. The aim of the present study was to determine the expression level and activity of HO-1 in Korean colon cancer tissues and cell lines. HO-1 protein expression was higher (>1.5-fold) in tumor tissues than in adjacent normal tissues in 14 of 20 colon cancer patients, and HO-1 protein expression was closely correlated with HO-1 enzyme activity in cancer tissues. Immunohistochemical data confirmed that HO-1 protein was expressed at a higher level in colon cancer tissues than in normal mucosa. Furthermore, HO-1 mRNA and protein expression and enzyme activity were higher in the colon cancer cell lines Caco-2, SNU-407, SNU-1033, HT-29, and SW-403 than in the normal fetal human colon cell line FHC. Treatment with the HO-1 inhibitor zinc protoporphyrin decreased the viability of colon cancer cell lines. These data indicate that HO-1 may serve as a clinically useful biomarker of colon cancer and as a target for anticolon cancer drugs.</P>
( Seong Hee Kang ),( Minjong Lee ),( Moon Young Kim ),( Seul Ki Han ),( Jun Hyeok Lee ),( Baek Gyu Jun ),( Tae Suk Kim ),( Dae Hee Choi ),( Ki Tae Suk ),( Young Don Kim ),( Gab Jin Cheon ),( Dong Joon 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: This study investigated the effect of non-selective ß-blockers (NSBB) in real-life situations and whether low-dose NSBB is beneficial compared to maximally tolerated doses. Methods: Study participant of 890 were divided into two groups: primary prophylaxis (PP) and secondary prophylaxis (SP); 595 in the PP group (NSBB = 370, non-NSBB = 225) and 291 in the SP group (NSBB = 217, non-NSBB = 74). The NSBB group was sub-divided into 2 groups: low-dose (≤ 80 mg) and high-dose (>80 mg). Hepatic venous pressure gradient (HVPG) measurement was performed before NSBB treatment in the majority of patients (n=803). Results: In the PP group, 272 patients received NSBB only, while 98 patients received NSBB plus endoscopic band ligation (EBL) (low-dose NSBB, n=170; high-dose NSBB, n=200). The NSBB group showed similar survival rates to the non-NSBB group. However, NSBB was partially effective for patients who had clinically significant portal hypertension (CSPH, HVPG ≥10 mmHg: hazard ratio [HR], 0.63; P=0.02) or CTP class B/C (HR, 0.59; P=0.01). The low-dose NSBB had significant reductions in the risk of mortality compared with the non-NSBB (HVPG ≥10 mmHg: HR, 0.55; P=0.02 and CTP class B/C: HR, 0.52; P=0.01), but effect size was weaker in the high-dose NSBB. In the SP group, 217 received NSBB plus EBL (low-dose NSBB, n=87; high-dose NSBB, n=130). NSBB prolonged survival regardless of the severity of portal hypertension (adjusted HR, 0.56; P<0.001). The low-dose NSBB had a greater benefit with a 58% risk reduction in mortality compared to a 39% risk reduction in mortality in the high-dose NSBB. Conclusions: NSBB therapy was partially associated with longer survival in patients of the PP group with CSPH. In the SP group, NSBB therapy improved survival, and relatively low-dose NSBB had a greater benefit than standard-titrated high-dose NSBB.
이천희(Cheon Hee Lee),강기희(Gi Hee Kang),오근희(Keun Hee Oh),전형권(Hyeong Kwun Jeon),김경렬(Kyoung Ryoul Kim) 한국여가레크리에이션학회 2002 한국여가레크리에이션학회지 Vol.23 No.-
The purpose of this study is to examine Present condition of the middle school students` participation in leisure activity and to identify constraining factors to participate in leisure activity them. Subjects of this study is 280 from 8 middle school in Seoul by Stratified cluster random sampling method. Questionnaire was used to examine Present condition of the middle school students` participation in leisure activity and to identify constraining factors to participate in leisure activity. Statistical techniques for data analysis is Frequency, Chi-square(x^2) and Means method. The researcher concluded as follows. First, In gender variable, male more participate in sport area for leisure activity and female more participate in taste & culture area for leisure activity. But all of them want to participate in sports area for leisure activity. Second, in grade, first and second grade more participate in sports area for leisure activity and third grade more participate in taste & culture area for leisure activity. But all of them want to participate in sports area for leisure activity. Third, in male, most constraining factors to participate in leisure activity is study & work, and in female, most constraining factors to participate in leisure activity is difficulty of choice that they will participate in what kinds of leisure activity. Fourth, in first and second grade, most constraining factors to participate in leisure activity is difficulty of choice that they will participate in what kinds of leisure activity, and in third grade, most constraining factors to participate in leisure activity is leisure activity fee.
Hemophagocytic lymphohistiocytosis diagnosed by brain biopsy
Ju, Hee Young,Hong, Che Ry,Kim, Sung Jin,Lee, Ji Won,Kim, Hyery,Kang, Hyoung Jin,Park, Kyung Duk,Shin, Hee Young,Chae, Jong-Hee,Phi, Ji Hoon,Cheon, Jung-Eun,Park, Sung-Hye,Ahn, Hyo Seop The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.9
Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this condition. In the present report, we describe the case of a patient diagnosed with HLH, in whom the brain pathology, but not the bone marrow pathology, showed hemophagocytosis. As the diagnosis of HLH is difficult in many cases, a high level of suspicion is required. Moreover, the pathologic diagnosis of organs other than the bone marrow, liver, and lymph nodes may be a useful alternative.
( Seong Hee Kang ),( Moon Young Kim ),( Minjong Lee ),( Baek Gyu Jun ),( Tae Suk Kim ),( Dae Hee Choi ),( Ki Tae Suk ),( Young Don Kim ),( Gab Jin Cheon ),( Soon Koo Baik ),( Dong Joon Kim ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The effect of non-selective β-blockers (NSBB) on survival in cirrhosis is still disputed. Moreover, most physicians use low-dose NSBB for cirrhosis due to decreased systemic pressures. We investigates whether low-dose NSBB can have beneficial effects in cirrhosis and the NSBB impact on survival in both primary prophylaxis (PP) and secondary prophylaxis (SP). Methods: We conducted study involving 890 consecutive patients with/without NSBB treatment in either PP or SP; 596 patients in PP (NSBB = 371, non-NSBB = 225) and 291 patients in SP (NSBB = 217, non-NSBB = 74). The NSBB group was divided into two sub-groups: low-dose NSBB group (≤ 80 mg) and high-dose NSBB group (> 80 mg). Results: In the PP group, 273 received only NSBB, while 98 received NSBB + endoscopic band ligation (EBL) in NSBB patients; 170 patients were in the low-dose and 201 patients were in the high-dose group. During the median follow-up of 40.0 months (Interquartile range [IQR], 15.0-58.8), NSBB showed similar survival rates to non-NSBB (log-rank, P=0.685). In addition, there was no difference in survival between low-dose NSBB compared to high-dose NSBB (log-rank, P=0.311). In the SP group, 217 received NSBB + EBL among the NSBB patients; 87 patients in the low-dose group and 130 patients in the high-dose group. The probability of survival was higher in patients who received NSBB (P<0.001). Multivariate analysis also revealed that NSBB significantly prolonged survival (adjusted hazard ratio, 0.490; P<0.001). However, overall survival did not significantly differ between low-dose NSBB and high-dose NSBB (P=0.131). Conclusions: In cirrhosis, NSBB therapy was associated with a reduced risk of mortality in SP but not in PP. Moreover, our study showed that there was a similar effect on survival when low-dose NSBB was used in SP.