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Chen, Zhi-Qing,Zhou, You,Huang, Jun-Wen,Chen, Feng,Zheng, Jing,Li, Hao-Liang,Li, Tao,Li, Lang The Korean Society of Pharmacology 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.2
Coronary microembolization (CME) is associated with cardiomyocyte apoptosis and cardiac dysfunction. Puerarin confers protection against multiple cardiovascular diseases, but its effects and specific mechanisms on CME are not fully known. Hence, our study investigated whether puerarin pretreatment could alleviate cardiomyocyte apoptosis and improve cardiac function following CME. The molecular mechanism associated was also explored. A total of 48 Sprague-Dawley rats were randomly divided into CME, CME + Puerarin (CME + Pue), sham, and sham + Puerarin (sham + Pue) groups (with 12 rats per group). A CME model was established in CME and CME + Pue groups by injecting 42 ㎛ microspheres into the left ventricle of rats. Rats in the CME + Pue and sham + Pue groups were intraperitoneally injected with puerarin at 120 mg/kg daily for 7 days before operation. Cardiac function, myocardial histopathology, and cardiomyocyte apoptosis index were determined via cardiac ultrasound, hematoxylin-eosin (H&E) and hematoxylin-basic fuchsin-picric acid (HBFP) stainings, and TdT-mediated dUTP nick-end labeling (TUNEL) staining, respectively. Western blotting was used to measure protein expression related to the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β) pathway. We found that, puerarin significantly ameliorated cardiac dysfunction after CME, attenuated myocardial infarct size, and reduced myocardial apoptotic index. Besides, puerarin inhibited cardiomyocyte apoptosis, as revealed by decreased Bax and cleaved caspase-3, and up-regulated Bcl-2 and PI3K/Akt/GSK-3β pathway related proteins. Collectively, puerarin can inhibit cardiomyocyte apoptosis and thus attenuate myocardial injury caused by CME. Mechanistically, these effects may be achieved through activation of the PI3K/Akt/GSK-3β pathway.
Chen Kun,Chen Xi,Lang Chuandong,Yuan Xingshi,Huang Junming,Li Zhi,Xu Mingyou,Wu Kerong,Zhou Chenhe,Li Qidong,Zhu Chen,Liu Lianxin,Shang Xifu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The identification of key regulatory factors that control osteoclastogenesis is important. Accumulating evidence indicates that circular RNAs (circRNAs) are discrete functional entities. However, the complexities of circRNA expression as well as the extent of their regulatory functions during osteoclastogenesis have yet to be revealed. Here, based on circular RNA sequencing data, we identified a circular RNA, circFam190a, as a critical regulator of osteoclast differentiation and function. During osteoclastogenesis, circFam190a is significantly upregulated. In vitro, circFam190a enhanced osteoclast formation and function. In vivo, overexpression of circFam190a induced significant bone loss, while knockdown of circFam190a prevented pathological bone loss in an ovariectomized (OVX) mouse osteoporosis model. Mechanistically, our data suggest that circFam90a enhances the binding of AKT1 and HSP90β, promoting AKT1 stability. Altogether, our findings highlight the critical role of circFam190a as a positive regulator of osteoclastogenesis, and targeting circFam190a might be a promising therapeutic strategy for treating pathological bone loss.
Kao-Lang Liu,Yu-Feng Wang,Yeun-Chung Chang,Shu-Chien Huang,Shyh-Jye Chen,Yuk-Ming Tsang,Chin-Chen Chang 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.3
This pictorial review provides the principles of extracorporeal membrane oxygenation (ECMO) support and associated CT imaging features with emphasis on the hemodynamic changes and possible imaging pitfalls encountered. It is important that radiologists in ECMO centers apply well-designed imaging protocols and familiarize themselves with post-contrast CT imaging findings in patients on ECMO.
Finite-control-set model predictive control for magnetically coupled wireless power transfer systems
Qi, Chen,Lang, Zhengying,Li, Tao,Chen, Xiyou The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.7
Output voltage control is an important subject in magnetically coupled wireless power transfer (MC-WPT) applications. Conventional control methods for MC-WPT systems use the PI controller. However, this method suffers from three issues: time-consuming tuning work of the PI parameters, increased control complexity due to the needs of the modulator, and poor dynamic performance. To provide an attractive alternative to the PI controller, a novel output voltage regulation method based on finite-control-set model predictive control (FCS-MPC) has been proposed for a MC-WPT system. The proposed method has inherent advantages such as a very intuitive concept, no need for a modulator, and fast dynamic response. Moreover, it can achieve soft switching by constructing pulse-density-modulation-based voltage pulse sequences as the control set. The design and implementation of the proposed controller are discussed in this paper. The proposed control method has been tested on a series-series-compensated MC-WPT system, and experimental results demonstrate the effectiveness of the proposed control method in comparison with PI control methods.
Xiaohui Chen,Lang Lang,Hongru Liu 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.87 No.6
In this study, the uniaxial ratcheting effect of Z2CND18.12N austenitic stainless steel at room and elevated temperatures is firstly simulated based on the Ahmadzadeh-Varvani hardening rule (A-V model), which is embedded into the finite element software ABAQUS by writing the user material subroutine UMAT. The results show that the predicted results of A-V model are lower than the experimental data, and the A-V model is difficult to control ratcheting strain rate. In order to improve the predictive ability of the A-V model, the parameter γ2 of the A-V model is modified using the isotropic hardening criterion, and the extended A-V model is proposed. Comparing the predicted results of the above two models with the experimental data, it is shown that the prediction results of the extended A-V model are in good agreement with the experimental data.
Development of a Small Tea Plucking Machine
( Ping-lang Yen ),( Nai-wen Chang ),( Chen-ya Chen ),( Hong-xuan Wei ),( Shih-fangchen ),( Wei-yang Hwang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Tea plucking in Taiwan suffers of serious labor shortage due to agricultural population decreasing and aging. The problems become even worse in hot season of tea plucking and cause tremendous economic loses for farmers. Current solutions of introducing tea harvesting machinery to substitute human power were not adequately suitable to Taiwan's geographical specialty. These machines were found difficult to operate efficiently in mountain areas, or in small tea farms, and farms with narrow ridge to ridge. This paper has proposed a tea plucking prototype that is specially designed to operate in mountain areas and for small scale tea farm. The machine contains a carrier, a tea cutter and a motorized mechanism. The carrier of small size was able to be moved by human and its tea plucking module is motorized. At the same time the height of cutter was automatically adjusted by the controller so that tea leaves can be evenly trimmed during the carrier movement. The prototype successfully demonstrated the efficiency of tea plucking can be increased and workload for human could be significantly reduced. In conclusion, the developed small electrical tea plucking machine was proved feasible for the release of labor shortage problem in Taiwan’s tea plucking industry.
Co‑doped amorphous MoSx for efficient hydrogen evolution reaction in acid condition
Lang Gan,Jincheng Liu,Yanjie Ren,Zhongyi Xiong,Kang Chen 한국탄소학회 2023 Carbon Letters Vol.33 No.5
Amorphous molybdenum sulfide ( MoSx) has been regarded as a promising hydrogen evolution reaction (HER) catalyst due to its mild preparation conditions and low-cost precursor materials. In this work, we report a simple strategy combining the growth of amorphous MoSx on the surface of metal organic frameworks (ZIF-67) and annealing treatment to prepare Co-doped MoSx nanopolyhedrons (denoted as CoMoSx NPs). The CoMoSx NPs exhibit excellent HER activity in acid condition with an overpotential of 188 mV at a current density of 10 mA cm? 2 (η10), and a relatively stable overpotential after 2000 cyclic voltammetry (CV) cycles testing. The excellent HER performance of the CoMoSx NPs can be attributed to the doping of Co element adjust the electronic structure and increase the conductivity of catalyst, and the nanopolyhedrons structure which can expose more active sites for HER electrocatalytic. This study offers a low-cost and simple strategy to prepare high-activity HER catalyst, which holds great promises in developing advanced electrocatalysts for energy storage.
DABC: A dynamic ARX-based lightweight block cipher with high diffusion
Wen Chen,Lang Li,Ying Guo 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.1
The ARX-based lightweight block cipher is widely used in resource-constrained IoT devices due to fast and simple operation of software and hardware platforms. However, there are three weaknesses to ARX-based lightweight block ciphers. Firstly, only half of the data can be changed in one round. Secondly, traditional ARX-based lightweight block ciphers are static structures, which provide limited security. Thirdly, it has poor diffusion when the initial plaintext and key are all 0 or all 1. This paper proposes a new dynamic ARX-based lightweight block cipher to overcome these weaknesses, called DABC. DABC can change all data in one round, which overcomes the first weakness. This paper combines the key and the generalized two-dimensional cat map to construct a dynamic permutation layer P1, which improves the uncertainty between different rounds of DABC. The non-linear component of the round function alternately uses NAND gate and AND gate to increase the complexity of the attack, which overcomes the third weakness. Meanwhile, this paper proposes the round-based architecture of DABC and conducted ASIC and FPGA implementation. The hardware results show that DABC has less hardware resource and high throughput. Finally, the safety evaluation results show that DABC has a good avalanche effect and security.
Liu Lang,Tang Hongcheng,Huang Baojian,Wang Kang,Balakrishnan Balachandar,Chen Maohua 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.2
Glutathione S-transferases (GSTs) play a major role in the detoxification of insecticides and the protection against oxidative damage caused by ROS (reactive oxygen species). The bird cherry-oat aphid, Rhopalosiphum padi (L.), is a major crop pest worldwide. Chemical insecticides are currently used to control aphids, but insecticide resis tance is an evolutionary issue for aphid control. In this research, we identified and cloned the full-length cDNA of a theta-class GST gene (RpGSTT1) from R. padi, which contains 702 bp open reading frame encoding 233 amino acids. RpGSTT1 was clustered together with theta classe of insect GSTs in the phylogenetic tree. Effect of insecticide exposure on the GST enzyme activity was investigated in vivo. After affinity purification, the re combinant RpGSTT1 protein was able to catalyze the conjugation of 1-chloro-2, 4-dinitrobenzene (CDNB). A disc diffusion assay showed that the RpGSTT1 can increase resistance to cumene hydroperoxide-induced oxidative stress. In addition, the purified recombinant RpGSTT1 protected super-coiled DNA from oxidative damage. By quantitative PCR, The relative expression level of RpGSTT1 in the aphid was highly up-regulated after 12 h exposure to β-cypermethrin, isoprocarb, malathion and sulfoxaflor, respectively. To our knowledge, RpGSTT1 is the first theta class of GST gene reported in bird cherry-oat aphid. Our findings indicate that RpGSTT1 may be involved in insecticide detoxification in R. padi.