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Qi Chaoqi,Du Yang,Yang Ping,Liu Zhengwu,Lyu Hongya,Zhao Kai,Guo Lijie 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.12
The phase composition, microstructure, tensile properties of TC4 samples produced by laser melting deposition (LMD)and LMD followed by solution-aging treatment were investigated to explore a simpler approach to improve the mechanicalperformances and eliminate negative influences by post treatment. The as-deposited TC4 microstructure showed a combinationof α΄martensite and α-colony with various shapes, such as acicular, rod-like and lamellar. As a synergistic result ofsolution and aging treatment, the dispersion strengthening of secondary-α as well as optimization on length-width ratio ofprimary-α and volume fraction of β-phase cause an increase in the ductility and strength. Meanwhile, there is a differencebetween microstructure of water-quenched specimens and air-cooled specimens, subsequently playing a key role in properties. The solution with air-cooling and aging is comparatively found to significantly reduce the anisotropy and improvecomprehensive performance.
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Yan Gao,Ding Yuan,Liyue Gai,Xuelian Wu,Yue Shi,Yumin He,Chaoqi Liu,Changcheng Zhang,Gang Zhou,Chengfu Yuan 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.3
Background: The decreased renal function is known to be associated with biological aging, of which the main pathological features are chronic inflammation and renal interstitial fibrosis. In previous studies, we reported that total saponins from Panax japonicus (SPJs) can availably protect acute myocardial ischemia. We proposed that SPJs might have similar protective effects for aging-associated renal interstitial fibrosis. Thus, in the present study, we evaluated the overall effect of SPJs on renal fibrosis. Methods: Sprague-Dawley (SD) aging rats were given SPJs by gavage beginning from 18 months old, at 10 ㎎/㎏/d and 60 ㎎/㎏/d, up to 24 months old. After the experiment, changes in morphology, function and fibrosis of their kidneys were detected. The levels of serum uric acid (UA), β2-microglobulin (β2-MG) and cystatin C (Cys C) were assayed with ELISA kits. The levels of extracellular matrix (ECM), matrix metalloproteinases (MMPs), tissue inhibitors of metalloproteinases (TIMPs), inflammatory factors and changes of oxidative stress parameters were examined. Results: After SPJs treatment, SD rats showed significantly histopathological changes in kidneys accompanied by decreased renal fibrosis and increased renal function; As compared with those in 3-month group, the levels of serum UA, Cys C and β2-MG in 24-month group were significantly increased (p < 0.05). Compared with those in the 24-month group, the levels of serum UA, Cys C and β2-MG in the SPJ-H group were significantly decreased. While ECM was reduced and the levels of MMP-2 and MMP-9 were increased, the levels of TIMP-1, TIMP-2 and transforming growth factor-β1 (TGF-β1)/Smad signaling were decreased; the expression level of phosphorylated nuclear factor kappa-B (NF-κB) was down-regulated with reduced inflammatory factors; meanwhile, the expression of nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) signaling was aggrandized. Conclusion: These results suggest that SPJs treatment can improve age-associated renal fibrosis by inhibiting TGF-β1/Smad, NFκB signaling pathways and activating Nrf2-ARE signaling pathways and that SPJs can be a potentially valuable anti-renal fibrosis drug.
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Dun, Yaoyan,Liu, Min,Chen, Jing,Peng, Danli,Zhao, Haixia,Zhou, Zhiyong,Wang, Ting,Liu, Chaoqi,Guo, Yuhui,Zhang, Changcheng,Yuan, Ding The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.1
Background: Saponins from Panax japonicus (SPJ) are the most abundant and main active components of P. japonicus, which replaces ginseng roots in treatment for many kinds of diseases in the minority ethnic group in China. Our previous studies have demonstrated that SPJ has the effects of anti-inflammation through the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-${\kappa}B$) signaling pathways. The present study was designed to investigate whether SPJ can modulate intestinal tight junction barrier in aging rats and further to explore the potential mechanism. Methods: Aging rats had been treated with different doses (10 mg/kg, 30 mg/kg, and 60 mg/kg) of SPJ for 6 mo since they were 18 mo old. After the rats were euthanized, the colonic samples were harvested. Levels of tight junctions (claudin-1 and occludin) were determined by immunohistochemical staining. Levels of proinflammatory cytokines (interleukin-$1{\beta}$ and tumor necrosis factor-${\alpha}$) were examined by Western blot. NF-${\kappa}B$ and phosphorylation of MAPK signaling pathways were also determined by Western blot. Results: We found that SPJ increased the expression of the tight junction proteins claudin-1 and occludin in the colon of aging rats. Treatment with SPJ decreased the levels of interleukin-$1{\beta}$ and tumor necrosis factor-${\alpha}$, reduced the phosphorylation of three MAPK isoforms, and inhibited the expression of NF-${\kappa}B$ in the colon of aging rats. Conclusion: The studies demonstrated that SPJ modulates the damage of intestinal epithelial tight junction in aging rats, inhibits inflammation, and downregulates the phosphorylation of the MAPK and $NF-{\kappa}B$ signaling pathways.
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