http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
안찬묵,우호범,Ahn Chan Mug,Ho Bum Woo 대한화학회 2003 대한화학회지 Vol.47 No.4
A strategy for synthesis of the furan-fused tetracyclic system of xestoquinone was explored through a model study. Using 3-butyn-1-ol as a starting material, 5-iodo-1-methoxymethoxy pentyne (5) was prepared in 5 steps. Reaction of ethyl 2-phenylpropanoate with 5 gave ethyl 7-methoxymethoxy-2-methyl-2-phenyl-5-heptynoate (6) in 88% yield, and then methyl 9-oxo-4-methyl-4-phenyl-2,7-nonadiynoate (13), the key intermediate, was synthesized in 6 steps from the ester 6. Intramolecular cycloaddition reaction of 13 afforded isobenzofuran 14 in 5% yield, which was converted to the tetracyclic structure 15 in the presence of Lewis acid. Xestoquinone의 퓨란-접합된 4환계화합물에 대한 합성전략을 모델연구를 통하여 조사하였다. 출발물질로서 3-butyn-1-ol을 이용하여, 5-iodo-1-methoxymethoxypentyne(5)이 5단계를 거쳐 제조되었다. Ethyl 2-phenylpropanoate와 5의 반응으로부터 ethyl 7-methoxymethoxy-2-methyl-2-phenyl-5-heptynoate(6)가 88%의 수득율로 얻어졌으며, 6으로부터 중요한 중간체인 methyl 9-oxo-4-methyl-4-phenyl-2,7-nonadiynoate(13)가 6단계를 거쳐 합성되었다. 13의 분자내 고리화반응은 5%의 수득율로 isobenzofuran 14을 생성하였으며, Lewis acid 존재 하에서 4환고리 구조로 전환되었다.
Effects of Mitosene Analogues on Growth Inhibition of Human Cervical Cancer Cell Lines
Dong-Soo Cha(차동수),Soo-Kie Kim(김수기),Chan-Mug Ahn(안찬묵),Sun-Ju Choi(최선주),Yoon-Sun Park(박윤선),Sang-Won Han(한상원) 대한의생명과학회 1997 Biomedical Science Letters Vol.3 No.2
실험적 자궁암 치료제로서 본 연구소에서 합성한 마이토센유사체를 인체 자궁암세포주인 SiHa, C33A, HeLa, CaSKi에 처리하여, 체외 항암활성 측정시 합성 마이토센유사체들은 이 들 세포주에 대하여 대조 항암제들에 비하여 의의있는 세포독성을 보였으며, SiHa 세포주를 이용한 종양클론형성억제검사에서는 22번 화합물만의 종양성장 억제활성이 가장 우수하였고 다른 화합물들은 대조항암제들에 비하여 활성이 낮았다. 이 마이토센유사체들에 대한 체외 항암감수성결과는 향후 전임상적인 자궁경부암 화합요법제의 기초자료로 유용할것으로 생각된다. To develop a promising alkylating agents for anti-cervical cancer chemotherapy, five mitosene analogues were synthesized. Despite the potentiality of better cytotoxicity on solid tumor cells as opposed to that on rapidly-doubled leukemic cells, there have been no reports on the inhibition of the cervical cancer cell line by mitosene analogues. The present experiment was designed to investigate whether mitosene analogues can effectively inhibit the cellular proliferation of cervical cancer cells by using an in vitro chemosensitivty system. The mitosene analogues displayed a potent cytotoxic effect on the tested cervical cancer cell lines. Among the analogues, (22) compound gave the best inhibitory effect on SiHa tumor colonies formation. These data indicate that mitosene analogues can effectively inhibit the growth of cervical cancer cells in vitro.
Sydnone 유도체들의 diazo coupling 반응에 관한 연구
안찬묵 연세대학교 대학원 1991 延世論叢 Vol.27 No.1
Diazo couplings at 3- or 4-phenyl ring of sydnone is described. First, nitration of 3,4-diphenylsydnone was examined under various conditions. It was found that the reaction took place only at the 4-phenyl ring of sydnone. Under CH3COOH-HNO3 conditions the parasubstitiuent was obtained, whereas the ortho- and para-substitiuent was obtained under H2SO4 -HNO3 conditions. The para-substituted compound was reduced with Fe and 2% aqueous CH3 COOH to give 3-phenyl- (4'-aminophenyl)sydnone. Diazo coupling with these amino compound in acidic conditions was tried, but the reaction did not proceed. Next, diazo coupling of 3 - phenylsydnone was examined. In order to obtain a compound which has an amino group at 3 - phenol ring, 3- (p-nitrophenyl)sydnone was reduced with Fe and 2% aqueous CH3COOH to give 3- (p-aminophenyl)sydnone. This amino compound was treated with sodium nitrite in acidic conditions, and then reacted with various reagents(I-VIII)to give auto compounds.
Selective Nitration에 의한 3-Phenyl-4-(p-aminophenyl) Sydnone의 합성
안찬묵,윤병희,유학수 연세대학교 자연과학연구소 1986 學術論文集 Vol.16 No.-
3,4-Diphenylsydnone에 조건을 변화시켜가면서 니트로화반응을 시켰다. 반응은 4위치의 phenyl에서만 일어났으며, CH_3COOH-HNO_3조건하에서는 para에 그리고 H_2SO_4-HNO_3조건하에서는 ortho와 para에 진행하여 각각 니트로화합물을 얻었다. 생물학적으로 활성을 갖을 것으로 기대되는 아미노기를 갖는 sydnone유도체를 얻기 위하여, 이 니트로화합물을 Fe와 2%초산수용액에 의해 환원시켰다. 이들 생성물의 확인은 IR과 NMR로 검토하였으며 원소분석으로 확정지었다. Nitration of 3,4-diphenylsydnone was examined under various conditions. Reaction took place only at phenyl which was at 4-position of sydnone ring, and it was found that para-substituent was obtained under CH_3COOH-HNO_3 condition, whereas under H_2SO_4-HNO_3 condition ortho-and para-substituent was obtained. In order to obtain amino group containing sydnone derivative which was expected to be biologically active, this nitro compound was reduced by iron and 2% aqueous acetic acid. The products thus obtained were identified by IR and NMR spectroscopy and confirmed by elemental analysis.