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      저자 : Carol E. O'Neil (검색결과 1 건)
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        Fourteen Weeks of Treatment with Viscofiber Increased Fasting Levels of Glucagon-Like Peptide-1 and Peptide-YY

        Frank Greenway,Carol E. O'Neil,Laura Stewart,Jennifer Rood,Michael Keenan,Roy Martin 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4

        Fermentable dietary fiber has been shown to cause fat loss and to increase peptide-YY (PYY) and glucagon-like peptide 1 (GLP-1) levels in rodents. In single meal tests, humans have an increase in PYY and GLP-1 to dietary fiber,but the response of these hormones to longer-term treatment is not known. Viscofiber?? (Cevena Bioproducts Inc., Edmonton,AB, Canada) is a high-viscosity fermentable dietary fiber made by a proprietary process from oats and barley. Seven healthyoverweight and obese subjects were treated with a calorie-restricted diet, a lifestyle change program, and 4 g of Viscofiber/dayfor 16 weeks. Hunger, satiety, PYY, and GLP-1 were measured before and 1 hour after a standard meal test before and atweek 14 of the study. Hunger and satiety were measured by Visual Analog Scales. PYY and GLP-1 were measured by ra-dioimmunoassay and enzyme-linked immunosorbent assay, respectively. Weight was reduced 3.07. 3.13 kg (P. .05) overthe 16 weeks. Fasting PYY increased 8.67. 6.62 pg/mL (P. .05) and fasting GLP-1 increased 2.67. 0.84 pmol/L (P..01) at 14 weeks compared to baseline. Satiety increased 1.78. 1.43 cm (P. .01) at the 1-hour post-meal time point onweek 14 compared to the study baseline. We conclude that 14 weeks of treatment with Viscofiber at 4 g/day along with alifestyle change program and diet causes weight loss and increases fasting PYY, fasting GLP-1, and satiety at 1 hour fol-lowing a standard meal, which extends the single meal test observations in humans.

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