Efficacy of phosphodiesterase type 5 inhibitors for the treatment of distal ureteral calculi: A systematic review and meta-analysis

Carlos Eduardo Montes Cardona,Herney Andrés García-Perdomo 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.2

Purpose: To determine the efficacy of phosphodiesterase type 5 inhibitors (PDE5i) as medical expulsive therapy (MET) for the treatment of distal ureteral calculi. Materials and Methods: A search strategy was conducted in the MEDLINE, CENTRAL, and Embase databases. Searches were also conducted in other databases and unpublished literature. Clinical trials were included without language restrictions. The risk of bias was evaluated with the Cochrane Collaboration's tool. An analysis of random effects due to statistical heterogeneity was conducted. The primary outcome was the expulsion rate of the distal ureteral calculus in 28 days. The secondary outcomes were the time to expulsion, side effects of treatment, and amount (mg) of nonopioid analgesia. The measure of the effect was the risk difference (RD) with a 95% confidence interval (CI). The planned interventions were PDE5i vs. placebo, tadalafil vs. placebo, and tadalafil vs. tamsulosin. Results: Four articles were included in the qualitative and quantitative analysis. Records of 580 patients were found among the four studies. A low risk of bias was shown for the majority of the study items. The calculi expulsion rate had an RD of 0.26 (95% CI, 0.15–0.37) and a less prolonged expulsion as a secondary outcome with a mean difference of -4.39 days (95% CI, -6.69 to -2.09) in favor of PDE5i compared with the placebo. No significant difference was found for these outcomes when comparing tadalafil with tamsulosin. Conclusions: Compared with a placebo, PDE5i could be effective as MET for the treatment of distal ureter calculi.

On Trapping Porphyrin Free-Bases Between Graphene Oxide Plates

Carlos J. Montes,María Luisa Ojeda,Federico Gonz alez,Miguel Angel García-Sanchez,Fernando Rojas,Celso Velasquez 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.4

A synergistic combination of properties between graphene oxide (GO) nanosheets and porphyrin molecules has been accomplished via the entrapment of the latter species within the pore space formed by parallel plates of the carbon material. A hybrid material, synthesized in this manner, would likely lead to the development of efficient photovoltaic cells, given the high capacity of porphyrin molecules to absorb sunlight or radiation of wavelength shorter than 700 nm as well as because of the excellent electron conduction and fine solar energy capture that can be achieved by the graphene substrate. Herein, materials consisting of trapped porphyrin molecules in-between GO plates have been prepared to develop preliminary solar cell devices for an efficient capture of sunlight energy. The hybrid systems created this way can be physicochemically characterized through diverse techniques, which include fluorescence emission to confirm and avail both the presence and manifest luminescent characteristics of the tetrapyrrolic species that are captured and retained in-between GO plates.

Factors associated with the survival of colorectal cancer in Mexico

( Carlos Quezada-gutiérrez ),( María Teresa Álvarez-bañuelos ),( Jaime Morales-romero ),( Clara Luz Sampieri ),( Raúl Enrique Guzmán-garcía ),( Evangelina Montes-villaseñor ) 대한장연구학회 2020 Intestinal Research Vol.18 No.3

Background/Aims: Colorectal cancer (CRC) is a public health problem. In Mexico, there have been no recent studies conducted on survival in terms of this pathology or on the influence of prognostic factors. The study aims to determine the probability of survival in patients with CRC presence of low levels of schooling and a rural population, adjusted for clinical stage and type of treatment. Methods: A retrospective study was conducted in a cohort of 305 patients with CRC treated at State Cancer Center, located in Veracruz-Mexico; the follow-up period of 60 months (2012-2016). The survival probability was calculated using the Kaplan-Meier estimator and the log-rank test with 95% confidence intervals (CIs). Prognostic factors were determined using hazard ratio (HR) multivariate Cox regression analysis. Results: Overall survival was 40% at 60 months. Subjects in the age group ≥65 years had a low survival rate of 28% (P=0.026) and an advanced clinical stage of 22% (P<0.001). Of the patients with bone metastasis, none survived longer than 5 years (P=0.008). With respect to the unfavorable prognostic factors identified in the multivariate analysis, a decreased level of schooling was associated with an HR of 7.6 (95% CI, 1.1-54.7), advanced clinical stage was associated with an HR of 2.1 (95% CI, 1.2-4.0), and the presence of metastasis had an HR of 1.8 (95% CI, 1.1-2.9). Conclusions: Poor prognostic factors include an advanced clinical stage, the presence of metastasis and a low level of schooling. These findings confirm the importance of screening for early diagnosis, diminishing the barriers to accessing treatment and prospectively monitoring the population. (Intest Res 2020;18:315-324)

Model-Based Control to Enhance a Novel Two Dimensional Positioning System

Chan Yet Wong,Carlos Montes,Laine Mears,John Ziegert 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10

This paper presents a model-based control algorithm to address the delayed feedback that occurs in a novel two dimensional positioning system. The delayed feedback causes the motion control system unable to track the desire setpoint accurately and at the same time introduce following error. Thus, a Modified Smith Predictor is proposed to address the delayed feedback by having an inner plant model to predict the path during the delay. Furthermore, an online system identification scheme is proposed to improve the accuracy of the model used in Modified Smith Predictor. Simulation and experimental results of the Modified Smith Predictor and online system identification are presented

Lens culinaris: A New Biocatalyst for Reducing Carbonyl and Nitro Groups

Daniele Alves Ferreira,Robério Costa da Silva,João Carlos da Costa Assunção,Marcos Carlos de Mattos,Telma Leda Gomes de Lemos,Francisco José Queiroz Monte 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.2

A series of aliphatic and aromatic aldehydes and ketones, as well as some nitrocompounds were reduced using whole plant cells from Lens culinaris seeds. In addition, we also investigated the possibility of enzymatic ester hydrolysis to explore the potential of these seeds. The reduced ketones products were obtained in yields of 8 ~82% and enantiomeric excess of 39 ~ 75%. Aldehydes were more reactive than ketones with high chemical yield (95→99%), whereas the aromatic nitrocompounds showed low (2%) to high (> 99%) conversion depending upon the nature and position of the aromatic ring substituents. Ester hydrolysis by the Lens culinaris was quite effective with the ester p-nitrophenyl acetate (> 99% conversion).

Soybean meal substitution by dehulled lupine (Lupinus angustifolius) with enzymes in broiler diets

Fredy Mera-Zuniga,Arturo Pro-Martinez,Juan F Zamora-Natera,Eliseo Sosa-Montes,Juan D Guerrero-Rodriguez,Sergio I Mendoza-Pedroza,Juan M Cuca-Garcia,Rosa M Lopez-Romero,David Chan-Diaz,Carlos M Becerri 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.4

Objective: Evaluate the effects of i) dehulling of lupine seed on chemical composition and apparent metabolizable energy (AME) and ii) soybean meal substitution by dehulled lupine seed in broiler diets with enzymes on productive performance, size of digestive organs and welfare-related variables. Methods: Experiment 1, chemical composition and AME were determined in whole and dehulled lupine seed. Experiment 2, two hundred eighty-eight one-day-old male Ross 308 broilers were used. The experimental diets were maize-soybean meal (MS), MS with enzymes (MSE) and maize-dehulled lupine seed with enzymes (MLE). Diets were assigned to the experimental units under a completely randomized design (eight replicates per diet). The body weight (BW) gain, feed intake, feed conversion, digestive organ weights, gait score, latency to lie down and valgus/varus angulation were evaluated. Results: The dehulling process increased protein (25.0% to 31.1%), AME (5.9 to 8.8 MJ/kg) and amino acid contents. The BW gain of broilers fed the MLE diet was similar (p>0.05) to that of those fed the MS diet, but lower than that of those fed the MSE diet. Feed intake of broilers fed the MLE diet was higher (p<0.05) than that of those fed the MS diet and similar (p>0.05) to those fed the MSE diet. Feed conversion of broilers fed the MLE diet was 8.0% and 8.7% higher (p<0.05) than that of those fed the MS and MSE diets, respectively. Broilers fed the MLE diet had the highest (p<0.05) relative proventriculus and gizzard weights, but had poor welfare-related variables. Conclusion: It is possible to substitute soybean meal by dehulled lupine seed with enzymes in broiler diets, obtaining similar BW gains in broilers fed the MLE and MS diets; however, a higher feed intake is required. Additionally, the MLE diet reduced welfare-related variables.