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RISS 인기검색어
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- 저자 : C. Velazquez (검색결과 4 건)
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Antibacterial and Antifungal Activities of Some Mexican Medicinal Plants
E. Ruiz-Bustos,C. Velazquez,A. Garibay-Escobar,Z. García,M. Plascencia-Jatomea,M.O. Cortez-Rocha,J. Hernandez-Martínez,R.E. Robles-Zepeda 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.6
In Mexico about 4,000 plant species have some medicinal use. The aim of this work was to evaluate the antimicrobial activity of six Mexican medicinal plants against fungi and Gram-positive and Gram-negative bacteria. Methanolic extracts were prepared from the Mexican medicinal plants Amphypteringium adstrigens, Castella tortuosa, Coutarea latiflora, Ibervillea sonorae, Jatropha cuneata, and Selaginella lepidophylla. The antibacterial and antifungal activities of the plants were determined by the broth microdilution method and the radial growth inhibition assay, respectively. All Mexican plants tested showed antimicrobial activity. Among the six plant extracts analyzed, J. cuneata showed the highest growth-inhibitory activity against fungi, Gram-positive and Gram-negative bacteria (J. cuneata > A. adstrigens > C. latiflora > C. tortuosa > I. sonorae ≈ S. lepidophylla). Shigella flexneri and Staphylococcus aureus were the most susceptible bacteria to plant extracts. Complete inhibition of S. flexneri growth was observed with J. cuneata methanolic extract at 90μg/mL. This plant extract also showed the strongest antifungal activity against Fusarium verticillioides and Aspergillus niger. Our data suggest that the medicinal plants tested have important antimicrobial properties. This is the first report describing the antimicrobial activities of several of the Mexican medicinal plants used in this study.
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Gonzalez-Herrera, A.L.,Salgado-Bernabe, M.,Velazquez-Velazquez, C.K.,Salcedo-Vargas, M.,Andrade-Manzano, A.,Avila-Moreno, F.,Pina-Sanchez, P. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Background: Cervical cancer (CeCa) is the second most common cancer in women in developing countries, and human papilloma virus (HPV) is the primary etiological factor. Aberrant expression of HOX transcription factors has been observed in several types of cancer. To date, however, no reports exist on the expression of HOXB2 and HOXB13 proteins during neoplastic progression in CeCa and its correlation with HPV infection. Materials and Methods: Expression of HOXB2 and HOXB13 proteins was assessed in tissue microarrays from normal cervical epithelium, cervical intraepithelial neoplasias grade 1-3, and CeCa. HPV was detected by PCR and sequencing. Expression of HOX-positive cells was determined in each diagnostic group. Results: Percentage of HOXB2- and HOXB13-positive cells gradually increased from means of 10.9% and 16.7%, respectively, in samples from healthy women, to 75.2% and 88.6% in those from CeCa patients. Frequency of HPV infection also increased from 13% in healthy tissue samples to 92.3% in CeCa. Both HOXB2 and HOXB13 proteins were preferentially expressed in HPV+ samples. Conclusions: The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.
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OECD/NEA Sandia Fuel Project phase I: Benchmark of the ignition testing
Adorni, M.,Herranz, L.E.,Hollands, T.,Ahn, K.I.,Bals, C.,D'Auria, F.,Horvath, G.L.,Jaeckel, B.S.,Kim, H.C.,Lee, J.J.,Ogino, M.,Techy, Z.,Velazquez-Lozad, A.,Zigh, A.,Rehacek, R. North-Holland Pub. Co 2016 Nuclear engineering and design Vol.307 No.-
The OECD/NEA Sandia Fuel Project provided unique thermal-hydraulic experimental data associated with Spent Fuel Pool (SFP) complete drain down. The study conducted at Sandia National Laboratories (SNL) was successfully completed (July 2009 to February 2013). The accident conditions of interest for the SFP were simulated in a full scale prototypic fashion (electrically heated, prototypic assemblies in a prototypic SFP rack) so that the experimental results closely represent actual fuel assembly responses. A major impetus for this work was to facilitate severe accident code validation and to reduce modeling uncertainties within the codes. Phase I focused on axial heating and burn propagation in a single PWR 17x17 assembly (i.e. ''hot neighbors'' configuration). Phase II addressed axial and radial heating and zirconium fire propagation including effects of fuel rod ballooning in a 1x4 assembly configuration (i.e. single, hot center assembly and four, ''cooler neighbors''). This paper summarizes the comparative analysis regarding the final destructive ignition test of the phase I of the project. The objective of the benchmark is to evaluate and compare the predictive capabilities of computer codes concerning the ignition testing of PWR fuel assemblies. Nine institutions from eight different countries were involved in the benchmark calculations. The time to ignition and the maximum temperature are adequately captured by the calculations. It is believed that the benchmark constitutes an enlargement of the validation range for the codes to the conditions tested, thus enhancing the code applicability to other fuel assembly designs and configurations. The comparison of lumped parameter and CFD computer codes represents a further valuable achievement.
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Dynamic Response of Low-Aspect-Ratio Cantilever NACA0012 Airfoil at Low-To-Moderate Reynolds Numbers
S. Martínez-Aranda,A. García-González,L. Parras,J. F. Velazquez-Navarro,C. del Pino 한국항공우주학회 2018 International Journal of Aeronautical and Space Sc Vol.19 No.3
The influence of the angle of attack (AoA) and the chord based Reynolds number (Rec) on the lift and drag coefficients has been analyzed experimentally in a low-aspect-ratio NACA0012 airfoil, AR = 2. Results are shown for chord based Reynolds numbers in the range 3.33 × 104 ≤ Rec ≤ 1.33 × 105 and AoA between 0º and +35º, the stall angle being close to 12º. The aerodynamic characteristics show an increase and decrease of lift and drag force fluctuations for AoA greater than the stall angle. The explanation of how these aerodynamic variations appear has been reported numerically and it is based on two-dimensional effects which are mainly the unstable laminar separation bubble (LSB) and the subsequent downstream propagation of leading edge vortex (LEV) as AoA increases. In addition, the dynamic response of the wing has been studied using frequency analysis. We compute the power spectral density (PSD) from the temporal evolution of the net force exerted over the wing, showing that the main response of the wing is the presence of two natural frequencies of the wing-base system. The mean PSD suddenly increases for Rec ≈ 1 × 105, particularly at AoA exceeding the critical point that corresponds to the stall angle. Finally, and despite from the fact that our model is rigid, we find PSD peaks at very low and high frequencies in agreement with other authors’ results which correspond to energetic modes in the wingtip vortex and the formation and emission of coherent turbulent structures behind the airfoil, respectively.
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