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Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法
徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4
The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.
Pyrantel Pamoate (Combantrin)에 依한 蛔蟲 및 鉤蟲感染의 集團治療
徐丙卨,朴定圭,趙昇烈,姜信榮,魚光本,康世喆,李源宰,李正雨,黃邱一 中央醫學社 1972 中央醫學 Vol.23 No.6
The mass treatment trial of pyrantel pamoate on Ascaris lumbricoides and Ancylostoma duodenale infections was carried out to school-children and inhabitants in rural areas in the central part of Korea. Pyrantel pamoate ("Combantrin") tablet (123 mg base) was administered as a single dose of 10. 0 mg per kg. body weight to a total of 4,198 Ascaris infected cases selected out of 4,436 (41. 6%) positives, who were screened from the total 10,660 collected stool specimens. Of these, only 3,169. cases were followed up after treatment to provide an analysis in this study. Incidentally 161 cases with concomittently infected hookworm were also subjected to assess the efficacy of pyrantel pamoate against A. duodenale. The egg negative conversion rate on A. lumbricoides was 95.3%, and on A. duodenale, 97.5% four weeks following treatment. In failed cases, the egg reduction rates on both of the infections were 97.6% and 97.3% respectively. No side effects and no problem in drug administration were demonstrated. It is concluded that this study confirms the high efficacy of pyrantel pamoate in the treatment of Ascaris lumbricoides and Ancylostoma duodenale infections and also proves the acceptability and safety of this drug in the mass treatment of ascariasis in a population with relatively high worm burden.
國産 Praziquantel (Cestocide^(�)의 無鉤條蟲 및 廣節裂頭條蟲에 對한 治療效果
蔡鐘一,孫運睦,洪性琮,李純炯,徐丙卨 대한화학요법학회 1985 대한화학요법학회지 Vol.3 No.2
Praziquantel(Cestocide^ⓡ), Korean product, was tested for its efficacy in the treatment of Taenia saginata and Diphylobothrium latum infection during the period from May 1983 to October 1985, A total of 30 patients were treated with 10~30㎎/㎏ single dose of praziquantel and purged with 20~30g of magnesium sulfate to recover the worms. The results were as follows: 1. The patients were 26 cases of T. saginata and 4 cases of D. latum and after the treatment all of them discharged tapeworm segments with or without their scolices. The scolex recovery rate was 43.3%(from 11 and 2 cases of T. saginata and D. Iatum respectively). 2. The follow[up examination for eggs and/or proglottides performed 2~3 months later or 11 out of 17 scolex-unidentified cases gave all negative results. From the results it is concluded that praziquantel(Cestocide^ⓡ) in 10㎎/㎏ single dose is highly effective in treatment of these tapeworm infections.
요꼬가와吸蟲症 治療에 있어서 Praziquantel(Distocide^(�))의 效果
李純炯,蔡鐘一,洪性琮,全英淑,徐丙卨 대한화학요법학회 1984 대한화학요법학회지 Vol.2 No.2
國産 praziquantel(Distocide^(ⓡ))의 요꼬가와吸蟲感染에 대한 治療效果를 알아보기 위하여 전라남도 강진군 탐진강 流域의 住民 중에서 68名의 蟲卵陽性者를 색출하고 體重당 100㎎/㎏의 praziquantel을 單回 투여한 후 70일에 追跡大使檢査를 실시하여 驅蟲效果를 判定하였다. 結果는 다음과 같다. 1. 총 45名의 追跡檢査者 중 41名이 蟲卵陰轉되어 91.1%의 治療率(care rate)을 보였으며 이들의 投藥前 E.P.G 合計가 125,600이었던 것이 投藥後 800으로 減少되어 99.4%의 蟲卵率을 보였다. 2. 驅蟲效果는 投藥前 感染强度(E.P.G)에 따라 다소 다른 것으로 나타났으며 輕感染者일수록 높은 效果를 보였다. 3. 藥劑服用에 의한 副作用은 2例에서 가벼운 頭痛이나 현기증을 호소한 이외에는 전혀 문제되지 않았다. 이상의 結果로 볼 때 國産 praziquantel(Distocide^(ⓡ)) 요꼬가와吸蟲症에 대하여 10㎎/㎏ 單回投與로 매우 우수한 驅蟲效果를 보이는 것이 立證되었고 效果, 投藥法, 副作用 등을 감안할 때 집단치료 약제로서 손색이 없을 것으로 생각되었다. Fraziquantel(Cistocide", Chinpoc:-g Pharm. Co). a 'croad spectrum anthelmintic zgzirs: tremato6es and cestodes, ~ 5 - i - a ~ tested for its efficacy In treatment of A!letclgonin.zis yok~govias infection. during the priod fron? Jzmsry t o Ajmi. 1984. A total of 68 egg ~ o s i t i r e cases TTES selected from the inhabitants of Kangjin-gun, South Choila Do, 2nd treated a i t h lOmg/kg ?x<:- weight of I;raziquar.te! in single dose. Among them 25 heavy infection cases were purged ~ i t l 20-20g of magnesium sulfzte(MIgS04) one hour after the treatrcent. Follow up stool exammztion was done after 70 days and the drug efficacy was estimated in terms of cure(=egg negati7-e conversion) and egg reduction rates. The results were as follows: 1. AIiong 45 follm- up cases 41 were cured(91.1% in cure rate) and the pre-treatment E.P. G.(eggs per gram of feces). 125,600, was reduced to 800 after the treatment(gg.4X in egg reduction rate). 2. The cure rates x-ere dependent upon the degiee of E.P.G.; the lower the intensity of infection before treatment, the higher the cure rate was obtained. 3. There x-ere nearly no side effects due t o drug administration except f o r slight degree of headache and dizziness in 2 cases. From these results, it is concluded that lOmg/kg single dose of praziquantel (Distocide") is highly recommendable in treatment of M. gokogawat infection.