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뇨중 Urinary Dipeptidase 의 근원에 대한 고찰
박행순,김도하,박성광,강성귀,Marlyn Burks,James M . Mullins,Benedict J . Campbell ( Haeng Soon Park,Doh Ha Kim,Sung Kwang Park,Sung Kyew Kang,Marlyn Burks,James M . Mullins,Benedict J . Campbell ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.4
Urinary dipeptidase, an enzyme with β-lactamase activity, was purified from the urine of healthy individuals. The purified enzyme was monophoretic when examined in polyacrylamide gel electrophoresis at pH 8.3, and its molecular mass estimated by HPLC was 227,000 daltons. It catalyzed the hydrolysis of the β-lactam antibiotic, N-formimidoyl-thienamycin (imipenem) with K_m=15.8 mM and V_(max)= 55 μ㏖/min/㎎. Lineweaver-Burk analysis of urinary dipeptidase-catalyzed hydrclysis of imipenem in the presence of cilastatin (Z-S-[6-carboxy-6-{ [2,2-dimethyl-(S)-cyclopropyl carboxy]-amino}-5-hexenyl]-L-cysteine) demonstrated reversible, competitive inhibition. The K_i for the competitive inhibitor, cilastatin, was 6 M. Renal dipeptidase was solubilized with n-butanol from membranes prepared from the kidneys of renal stone patients and purified. The two enzymes showed many properties in common including molecular mass, substrate specificity, kinetic parameters, inhibition by cilastatin, pH optima, electrophoretic mobility, and immunological cross-reactivity. Disintegration of kidney tubules and release of peptidase activity into the urine of rabbits treated with sublethal levels of the nephrotoxic agent, cephaloridine, suggest that the urinary dipeptidase originates from the proximal tubules of mammalian kidneys.
Korean Sovereignty : Eastern and Western Philosophy in the Kaleidoscope of History
BURKE, KENNETH M. 이화여자대학교 국제통상협력연구소 2010 Asian International Studies Review Vol.11 No.2
Throughout history, from obstacles involving foreign invasion and intervention coupled with domestic rivalry, the Korean peninsula struggled to legitimize and protect its sovereignty. This research involves an investigation and analysis of patterns in that history. The article provides a broad examination of Korean political development with interdisciplinary insights into sovereignty while underscoring the need for new approaches and epistemological unity in political philosophy. The Korean peninsula serves as an example of the challenges.
Sensory and motor axons are different: implications for neurological disease
Burke, David,Howells, James,Kiernan, Matthew C. The Korean Society of Clinical Neurophysiology 2017 Annals of Clinical Neurophysiology Vol.19 No.1
Using threshold tracking, differences have been established between large myelinated sensory and ${\alpha}$ motor axons in humans. Major differences are that sensory axons are relatively depolarised at rest such that they have a greater persistent $Na^+$ current, and have greater activity of hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels. Sensory axons may thereby be protected from hyperpolarising stresses, and are less likely to develop conduction block. However, the corollary is that sensory axons are more excitable and more likely to become ectopically active.