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RISS 인기검색어
- 검색키워드
- 저자 : Boladale O. Silva (검색결과 2 건)
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Tolulope O. Ajala,Boladale O. Silva 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.5
Acid neutralizing capacity (ANC) of antacids is an important indicator of the efficacy of such products. The purpose of this study is to evaluate the effect of pharmaceutical properties on the ANC of antacid oral suspensions. Fifteen antacid oral suspensions randomly sourced from different manufacturers and coded A1-A15 were assessed using ANC, raft formation, sedimentation profiles, ease of re-dispersibility, density, alkalinity, particle size, viscosity and rheological patterns. The effects of the pharmaceutical properties were discussed on the ANC and conclusions drawn. The results showed that ten (66.67 %) of the samples passed the ANC test among which 5 (83.33 %) were nonsedimenting highly viscous suspensions. One sample (A5) presented raft formation. Sedimentation volume reduces with time, ease of re-dispersibility was in seconds and the density range for all samples was 1.06–1.26 g/mL. The particle sizes of the antacid oral suspensions were within the range for coarse dispersions. The viscosity values ranged from 39.33 ± 1.53 to 2508 ± 24.33 cp. The rheogram of A3 shows a Newtonian flow with a regression coefficient of 0.999 and it had the least ANC. Other samples present non- Newtonian flow in a pseudoplastic pattern. Comparison of the viscosity of samples with ANC shows no direct relationship between the two variables although most samples with low viscosity failed the ANC test. The acid neutralizing capacity of the antacid oral suspensions is influenced by the dynamics of different parameters including type of active pharmaceutical ingredient, sedimentation profile, viscosity and overall rheology of the suspension.
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High Cadmium Levels in Cured Meat Products Marketed in Nigeria - Implications for Public Health
Adejumo, Olufunmilayo E,Fasinu, Pius S,Odion, Judith E,Silva, Boladale O,Fajemirokun, Timothy O Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Heavy metals are known to disrupt important physiological processes in living cells, and have been responsible for various pathological conditions with possible contributions to cancer development. Food contamination have been identified as one of the ways humans are exposed to heavy metals. In developing countries like Nigeria, the regulatory framework for enforcing compliance with globally acceptable exposure to deleterious contaminants is poor. In the current study, thirteen samples of cured meat products of diverse origin marketed in South-west Nigeria were evaluated for lead, cadmium, chromium and nickel contents using the atomic absorption spectroscopy technique. All the samples analysed contained cadmium between 0.35 and 1.20 ppm, levels considered higher than acceptable limits in consumable products. Lead, chromium and nickel were not detected in any of the samples. As known cumulative poisons, there is the need for stringent regulatory control of these heavy metals in cured meat products imported into or produced indigenously in the country in order to minimize the risks to public health.
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