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Pelvic floor muscle strength is correlated with sexual function
Dulcegleika Vilas Boas Sartori,Paulo Roberto Kawano,Hamilto Akihissa Yamamoto,Rodrigo Guerra,Pedro Rochetti Pajolli,João Luiz Amaro 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.1
Purpose: Sexual performance is related to proprioception and pelvic floor muscle strength (PFMS). The aim of this study was to correlate sexual activity and orgasm with PFMS. Materials and Methods: A total of 140 healthy continent female were prospectively distributed into 4 groups according to age: Group 1 (G1), 30–40; Group 2 (G2), 41–50; Group 3 (G3), 51–60; Group 4 (G4), over 60 years old. Evaluated parameters were: frequency of sexual activity and orgasm achievement; body mass index (BMI) and objective evaluation of PFMS using perineometer and surface electromyography. Results: BMI was higher in G4 compared to G1 (p=0.042). Women who reported sexual activity was significantly higher in G1 compared to G3 and G4 (94.1% vs. 66.7% and 37.5%, respectively; p=0.001). Orgasm was more frequently in G1 compared to G3 and G4 (91.2% vs. 63.9% and 28.1%, respectively; p=0.001), demonstrating that sexual activity and orgasm decrease after age 51. The duration of PFM contraction was significantly higher in women who had sexual intercourse (p=0.033) and orgasm (p=0.018). Conclusions: Although the frequency of sexual intercourse and orgasm may decrease with aging, a relationship between sexual activity and PFMS remains apparent, once both sexually active women and those who have orgasms showed better PFM endurance than non-sexually active ones.
A Study of Radiation Doses to the Patient and Medical Team at Embolization Procedures
Castilho, Alvaro Vilas Boas,Szjenfeld, Denis,Nalli, Darcio,Fornazari, Vinicius,Moreira, Antonio Carlos,Medeiros, Regina Bitelli The Korean Association for Radiation Protection 2019 방사선방어학회지 Vol.44 No.3
Background: This study aimed to estimate occupational doses and patient peak skin doses (PSDs) during interventional radiology procedures. Materials and Methods: We examined data from brain embolization (n = 30), hepatic chemoembolization (n = 50), and uterine embolization (n = 12). The PSDs were measured using radiochromic film around the patient's head (group 1) or abdominal/pelvic region (group 2). Acquisition technical data and kerma-area products (KAP) were also recorded. Occupational doses were measured using $Instadose^{TM}$ dosimeters near the left eye region (LER), chest, and left ankle. Results and Discussion: The third quartile (median) KAP values were $408.1(235.3)Gy{\cdot}cm^2$ for group 1 and $584.4(449.4)Gy{\cdot}cm^2$ for group 2. The average PSDs were greatest during vascular procedures, reaching 1,004.4 (786.4) mGy, and the highest PSD was 2,352.6 mGy (during hepatic chemoembolization). The third quartile (median) occupational doses were 0.35 (0.21) mSv at the LER, 0.25 (0.15) mSv at the chest, and 1.47 (0.64) mSv at the left ankle. Occupational doses at the LER were higher than at the chest, which highlights the importance of protective glasses and suspended shields. The occupational doses at the ankle region were also high, which highlights the importance of using a lead-lined curtain attached to the table. Conclusion: The results indicate that physicians can reach, for eye region, the weekly occupational dose limit after around 15 procedures, even when using proper protection. The average PSD values were below the threshold for tissue reactions, although the complexity of these procedures emphasises the importance of considering related risks.
한스 보아스 ( Hans C. Boas ) 서울대학교 독일어문화권연구소 2021 독일어문화권연구 Vol.30 No.-
Dieser Beitrag gibt einen Überblick über das 2001 an der University of Texas at Austin gegründete Texas German Dialect Project (TGDP). Besonderes Augenmerk wird dabei auf das vom TGDP erstellte Texas German Dialect Archive (TGDA) gelegt, in dem die Aufnahmen von Interviews mit hunderten Sprechern des Texas-Deutschen, ein vom Aussterben bedrohter Auswandererdialekt, der seit den 1840er Jahren gesprochen wird, archiviert werden. Der Beitrag zeigt außerdem, wie die im frei zugänglichen Online-Dialektarchiv enthaltenen Tonaufnahmen der Interviews mit den dazugehörigen Transkriptionen und Übersetzungen (ins Englische) für Lehr- und Forschungsaktivitäten benutzt werden können.
Nvivo 분석을 활용한 간호학생의 자기성찰적 인성수업의 효과탐색
김미한,Boas Yu 한국지식정보기술학회 2021 한국지식정보기술학회 논문지 Vol.16 No.5
본 연구의 목적은 자기성찰에 기반을 둔 명상을 활용한 수업이 간호대학생에게 미치는 효과를 파악하여, 간호사의 핵심역량에 기여하는 인성프로그램으로서의 활용가능성을 확인하기 위함이다. 연구대상자는 K시 소재 간호대학 4학년 22명이며, 양적자료수집과 질적자료수집이 포함된 혼합연구모형(mixed method)을 적용하였다. 수업 전과 후에 임상실습 스트레스에 대한 구조화된 설문지를 통하여 수집된 양적자료는 대응표본 willcoxon 부호순위검정을 사용하여 분석하였고, 질적자료인 자기성찰에세이는 NVIVO 12.0 Plus프로그램을 활용하여 노드(node)분석을 실시하였다. 연구의 결과, 자기성찰적 인성수업은 간호학생의 실습환경, 역할갈등, 사회적요인, 과제물로 인한 임상실습 스트레스를 감소시켰다. 또한 질적자료 분석을 통해 규명한 한 자기성찰적 인성수업의 효과는 간호대학생의 자기이해, 타인이해, 내면의 힐링, 자신감 회복, 새로운 수업경험, 긍정적 변화를 나타냈다. 따라서 자기성찰 활동을 적용한 이와 같은 수업은 전인적 간호를 제공하는 인성을 갖춘 간호사를 양성을 위한 인성수업개발의 기초자료가 될 수 있을 것으로 사료된다.
Kim, Ji Hye,Nam, Boas,Choi, Yun Jung,Kim, Seon Ye,Lee, Jung-Eun,Sung, Ki Jung,Kim, Woo Sung,Choi, Chang-Min,Chang, Eun-Ju,Koh, Jae Soo,Song, Joon Seon,Yoon, Shinkyo,Lee, Jae Cheol,Rho, Jin Kyung,Son, American Association for Cancer Research 2018 Cancer Research Vol.78 No.16
<P>Enhanced glycolysis by EGFR mutation is required for maintaining EGFR levels via inhibition of JNK-induced autophagy. This provides a promising rationale for use of JNK activators in patients with EGFR-mutated NSCLC.</P><P>Oncogenic EGFR is essential for the development and growth of non–small cell lung cancer (NSCLC), but the precise roles of EGFR in lung cancer metabolism remain unclear. Here, we show that EGFR mutation-mediated enhancement of glycolysis is critical for EGFR stability. EGFR knockdown significantly decreased levels of glycolytic pathway intermediates via transcriptional regulation of glycolytic genes. EGFR mutation-enhanced glycolysis was required for fueling the tricarboxylic acid cycle, a critical component of EGFR stability. Nonsustained ATP production enhanced reactive oxygen species accumulation and subsequent JNK-mediated activation of autophagy, which in turn induced EGFR degradation. Our data show that EGFR-mutant NSCLCs require EGFR mutation-enhanced glycolysis to maintain EGFR stability. This pathway may serve as an attractive therapeutic target for EGFR-mutant NSCLCs.</P><P><B>Significance:</B> Enhanced glycolysis by EGFR mutation is required for maintaining EGFR levels via inhibition of JNK-induced autophagy. This provides a promising rationale for use of JNK activators in patients with EGFR-mutated NSCLC. <I>Cancer Res; 78(16); 4482–96. ©2018 AACR</I>.</P>