http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Bijesh (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Surya Kant Tripathi,Kannan R. R. Rengasamy,Bijesh Kumar Biswal 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
Plumbagin is a naturally-derived phytochemicalwhich exhibits promising medicinal properties, includinganticancer activities. In the present study, the anticancerpotential of plumbagin has been demonstrated in lungcancer cells by targeting reactive oxygen species (ROS)and the intrinsic mitochondrial apoptotic pathway. Plumbaginshowed impressive cytotoxic, anti-proliferative,and anti-migratory activities with IC503.10 ± 0.5 μM and4.10 ± 0.5 μM in A549 and NCI-H522 cells, respectively. Plumbagin treatment significantly reduced the size of A549tumor spheroids in a concentration-dependent manner. Plumbagin enhanced ROS production and arrested lung cancercells in S and G2/M phase. Expression of antioxidantgenes such as glutathione S-transferase P1 and superoxidedismutase-2 were found to be upregulated with plumbagintreatment in A549 cells. Plumbagin induced dissipation inmitochondrial membrane potential and affected the expressionof intrinsic apoptotic pathway proteins. Increasedexpression of cytochrome c promotes the activation of proapoptoticprotein Bax with decreased expression of antiapoptoticprotein Bcl-2. Further, plumbagin activated themitochondrial downstream pathway protein caspase-9 andcaspase-3 leading to apoptosis of A549 cells. Collectively,plumbagin could be a promising future phytotherapeuticcandidate for lung cancer treatment via targeting intrinsicmitochondrial apoptotic pathway and ROS.
-
Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury
Prince Thakkar,Naveen B. Prakash,George Tharion,Sahana Shetty,Thomas V. Paul,Joseph Bondu,Bijesh Yadav 대한척추외과학회 2020 Asian Spine Journal Vol.14 No.1
Study Design: Prospective observational study. Purpose: To evaluate bone turnover markers (BTMs) in individuals with acute spinal cord injury (SCI) and to compare the results with those of healthy controls and postmenopausal females. Overview of Literature: SCI significantly impacts bone health. Change in bone mineral density appears 6 months after SCI and rapid bone loss during the acute phase is often underestimated, resulting in osteoporosis and a high risk of sublesional fractures. However, few studies have evaluated BTMs in the Indian SCI population. Despite a high risk of fracture, there are no guidelines for the diagnosis, monitoring, and management of SCI-induced osteoporosis. Methods: Twenty patients within 1 month of traumatic SCI who had been admitted to a tertiary care rehabilitation center were included in this study. Serum BTMs, C telopeptide (CTX) as a bone resorption marker, and osteocalcin as a bone formation marker, were serially measured at baseline, and 3 and 6 months after SCI. BTMs of SCI patients were compared with those of a control group of age-matched healthy males, premenopausal females, and a vulnerable group of postmenopausal females. Results: BTMs were significantly elevated in patients with SCI, with maximum levels observed at the 3rd month of injury. At baseline, the bone resorption marker CTX was approximately 3 times higher in SCI patients than in the control male population and premenopausal females, and about double that of postmenopausal females. The rise in the bone formation marker was marginal in comparison to that of the bone resorption marker. BTMs were persistently elevated and did not reach the normative range until the 6th month of SCI. Conclusions: Raised bone resorption markers in comparison to bone formation markers indicate hyper-resorption-related bone loss following acute SCI. Markedly elevated bone resorption markers in the SCI population, compared with those in control and vulnerable groups, emphasize the need for early bone health monitoring and management.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
