http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Surya Kant Tripathi,Kannan R. R. Rengasamy,Bijesh Kumar Biswal 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.2
Plumbagin is a naturally-derived phytochemicalwhich exhibits promising medicinal properties, includinganticancer activities. In the present study, the anticancerpotential of plumbagin has been demonstrated in lungcancer cells by targeting reactive oxygen species (ROS)and the intrinsic mitochondrial apoptotic pathway. Plumbaginshowed impressive cytotoxic, anti-proliferative,and anti-migratory activities with IC503.10 ± 0.5 μM and4.10 ± 0.5 μM in A549 and NCI-H522 cells, respectively. Plumbagin treatment significantly reduced the size of A549tumor spheroids in a concentration-dependent manner. Plumbagin enhanced ROS production and arrested lung cancercells in S and G2/M phase. Expression of antioxidantgenes such as glutathione S-transferase P1 and superoxidedismutase-2 were found to be upregulated with plumbagintreatment in A549 cells. Plumbagin induced dissipation inmitochondrial membrane potential and affected the expressionof intrinsic apoptotic pathway proteins. Increasedexpression of cytochrome c promotes the activation of proapoptoticprotein Bax with decreased expression of antiapoptoticprotein Bcl-2. Further, plumbagin activated themitochondrial downstream pathway protein caspase-9 andcaspase-3 leading to apoptosis of A549 cells. Collectively,plumbagin could be a promising future phytotherapeuticcandidate for lung cancer treatment via targeting intrinsicmitochondrial apoptotic pathway and ROS.
Synthesis, characterization and dielectric investigation of ZnO-doped polyaniline nanocomposites
Suman Lal,Surya Kant Tripathi,Rajesh Kumar,Nitin Sood,Samriti Khosla 한국정보디스플레이학회 2015 Journal of information display Vol.16 No.1
Polyaniline (PANI) synthesized through the in situ polymerization method and its composites with zinc oxide nanoparticles loaded in various weight percentages were studied. The formation of PANI and its composites was characterized using different characterizing tools, and detailed analysis was done to investigate the structural and morphological properties of the composites. The presence of the vibration band of the metal oxide and other characteristic bands of the composites, as characterized via Fourier transmission infrared spectroscopy, confirmed the synthesis of the polymer nanocomposites. The X-ray diffraction patterns of the nanocomposites revealed their polycrystalline nature. The dielectric responses of PANI and the ZnO-doped PANI composites were investigated within the frequency range of 20 Hz to 1 MHz. The dielectric constant of the ZnO-doped PANI composite was found to be higher than that of the pure PANI. The value of the dielectric constant decreased with increasing frequency, and it became constant at higher frequencies, which is attributed to the interfacialpolarization.