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Taywade, Sameer Kamalakar,Kumar, Rakesh,Bhethanabhotla, Sainath,Bal, Chandrasekhar The Korea Society of Nuclear Medicine 2016 핵의학 분자영상 Vol.50 No.3
Drug induced pulmonary toxicity is not uncommon with the use of various chemotherapeutic agents. Cyclophosphamide is a widely used chemotherapeutic drug in the treatment of breast cancer. Although rare, lung toxicity has been reported with cyclophosphamide use. Detection of bleomycin induced pulmonary toxicity and pattern of $^{18}F$-fluorodeoxyglucose ($^{18}F$-FDG) uptake in lungs on fluorodeoxyglucose positron emission tomography-computed tomography ($^{18}F$-FDG PET-CT) has been elicited in literature in relation to lymphoma. However, limited data is available regarding the role of $^{18}F$-FDG PET-CT in monitoring drug induced pulmonary toxicity in breast cancer. We here present two cases of cyclophosphamide induced drug toxicity. Interim $^{18}F$-FDG PET-CT demonstrated diffusely increased tracer uptake in bilateral lung fields in both these patients. Subsequently there was resolution of lung uptake on $^{18}F$-FDG PET-CT scan post completion of chemotherapy. These patients did not develop significant respiratory symptoms during chemotherapy treatment and in follow up.