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초파리의 말초신경계와 근육 세포의 발생에 관여하는 유전자의 특성
전상학,김윤택,Bellen, Hugo J . 한국유전학회 1999 Genes & Genomics Vol.21 No.3
Embryos of the A37 enhancer detector strain of Drosophila express the lacZ gene in the sensory mother cells and the developing and mature cells of the peripheral nervous system (PNS). The lacZ gene is also expressed in all muscle cells of larvae and adults, as well as in most imaginal disk sensory mother cells. However, it is confined to only a subset of the PNS cells in the adult. We characterized the developmental role of the gene, neuromusculin (nrm) which is located adjacent to the A37 insertion. The gene was cloned by screening genomic libraries of the enhancer detector strain using lacZ as a probe. Sequencing of cloned nrm cDNAs revealed that it encodes nine immunoglobulin (lg)-like domains. Whole mount in situ hybridizations using nrm cDNAs as probes exhibited an expression pattern similar to that of lacZ observed in A37 embryos. However, nrm transcripts are also present in embryonic muscles and few CNS neurons. Since many lg-like proteins have been implicated in cell adhesion, the adhesion properties of Nrm was demonstrated in Schneider 2 cells transfected with the complete nrm open reading frame. Our results suggest that Nrm mediates clustering of cells or fasciculation in the developing PNS. In addition, it may play a role in motoneuron growth cone guidance by muscles or PNS neurons.